OSMR

Understanding Entity Pages

This page aggregates everything SciDEX knows about OSMR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

OSMR encodes the Oncostatin M receptor, a type I cytokine receptor mediating IL-6 family signaling. Critical regulator of neuroinflammation implicated in Alzheimer's disease, Parkinson's disease, ALS, and multiple sclerosis through JAK/STAT3, MAPK/ERK, and PI3K/Akt pathways.

View on Wiki →

graph TD
    OSMR["<b>OSMR</b>"]
    Dementia{"Dementia"}
    OSMR -->|"associated with"| Dementia
    Alzheimer{"Alzheimer"}
    OSMR -->|"associated with"| Alzheimer
    Als{"Als"}
    OSMR -->|"associated with"| Als
    Inflammation{"Inflammation"}
    OSMR -->|"associated with"| Inflammation
    Ms{"Ms"}
    OSMR -->|"associated with"| Ms
    OSMR -->|"expressed in"| Ms
    Cancer{"Cancer"}
    OSMR -->|"expressed in"| Cancer
    Glioblastoma{"Glioblastoma"}
    OSMR -->|"expressed in"| Glioblastoma
    CTSD["CTSD"]
    OSMR -->|"associated with"| CTSD
    CCL3["CCL3"]
    OSMR -->|"associated with"| CCL3
    GFAP["GFAP"]
    OSMR -->|"associated with"| GFAP
    Dna_Methylation(["Dna Methylation"])
    OSMR -->|"expressed in"| Dna_Methylation
    VEGF["VEGF"]
    VEGF -->|"associated with"| OSMR
    TNF["TNF"]
    TNF -->|"associated with"| OSMR
    MYD88["MYD88"]
    MYD88 -->|"associated with"| OSMR
    CANCER["CANCER"]
    CANCER -->|"expressed in"| OSMR
    GBM["GBM"]
    GBM -->|"associated with"| OSMR
    style OSMR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0