gene

PLEC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLEC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

50Outgoing

15Incoming

Summary

Plectin - cytolinker protein in cytoskeletal organization and neurodegeneration

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🧬 Gene Info

Gene Symbol	PLEC
Full Name	Plectin
Chromosome	8q24.3
Protein Family	Plakin family, cytolinker proteins
Function	encodes a protein of approximately 500 kDa, making it one of the largest known proteins.
Primary Expression	dopaminergic neurons - Supports neuronal cytoskeletal integrity - Altered expression in PD
Molecular Weight	500 kDa
Gene Type	Protein-coding
UniProt ID	Q15120
NCBI Gene ID	5339
Ensembl ID	ENSG00000109189
OMIM	162284
GeneCards	PLEC
Human Protein Atlas	PLEC
Encoded Protein	Plectin
Associated Diseases	ALS, Alzheimer's Disease
Interactions	ASTROCYTES, RNA, ALZHEIMER, Proteins, C1Q
KG Connections	66 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PLEC — AlphaFold Q15120 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PLEC["<b>PLEC</b>"]
    Alzheimer_s_disease{"Alzheimer's disease"}
    PLEC -->|"biomarker for"| Alzheimer_s_disease
    brain_astrocytes["brain astrocytes"]
    PLEC -->|"expressed in"| brain_astrocytes
    Heart_Failure{"Heart Failure"}
    PLEC -->|"activates"| Heart_Failure
    Cardiovascular{"Cardiovascular"}
    PLEC -->|"therapeutic target"| Cardiovascular
    Alzheimer{"Alzheimer"}
    PLEC -->|"expressed in"| Alzheimer
    Als{"Als"}
    PLEC -->|"associated with"| Als
    Ms{"Ms"}
    PLEC -->|"activates"| Ms
    PLEC -->|"therapeutic target"| Als
    C1Q["C1Q"]
    PLEC -->|"expressed in"| C1Q
    CRYAB["CRYAB"]
    PLEC -->|"therapeutic target"| CRYAB
    CASP3["CASP3"]
    PLEC -->|"therapeutic target"| CASP3
    Mapk(["Mapk"])
    PLEC -->|"therapeutic target"| Mapk
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"associated with"| PLEC
    RS7529220["RS7529220"]
    RS7529220 -->|"expressed in"| PLEC
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"expressed in"| PLEC
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| PLEC
    GFAP["GFAP"]
    GFAP -->|"therapeutic target"| PLEC
    NDUFV1["NDUFV1"]
    NDUFV1 -->|"therapeutic target"| PLEC
    MAPK14["MAPK14"]
    MAPK14 -->|"therapeutic target"| PLEC
    style PLEC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (51)

Target	Relation	Type	Str
brain astrocytes	expressed_in	cell_type	0.70
Alzheimer's disease	biomarker_for	disease	0.70
Heart Failure	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
C1Q	expressed_in	gene	0.60
CRYAB	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60
Mapk	therapeutic_target	pathway	0.60
ASTROCYTES	activates	gene	0.60
GENES	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
MICROGLIA	associated_with	gene	0.60
RS7529220	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
Macrophage	associated_with	cell_type	0.60
Microglia	associated_with	cell_type	0.60
Astrocyte	activates	cell_type	0.60
GENETIC LOCI	associated_with	gene	0.60
RNA	activates	gene	0.60
Cardiomyocyte	activates	cell_type	0.60
Actin	therapeutic_target	protein	0.60
App	associated_with	protein	0.60
Alzheimer's disease	expressed_in	disease	0.60
Alzheimer's disease	activates	disease	0.60
endothelial cells	expressed_in	cell_type	0.60
astrocytes	expressed_in	cell_type	0.60
Alzheimer's disease	interacts_with	disease	0.60
Macrophage	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
Alzheimer'S Disease	expressed_in	disease	0.50
disease	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
Astrocytes	activates	cell_type	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
CARDIOMYOCYTES	activates	concept	0.50
ALZHEIMER	interacts_with	gene	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
Proteins	interacts_with	protein	0.50

Incoming (15)

Source	Relation	Type	Str
GFAP	therapeutic_target	gene	0.60
NDUFV1	therapeutic_target	gene	0.60
MAPK14	therapeutic_target	gene	0.60
C1Q	expressed_in	gene	0.60
C1Q	interacts_with	gene	0.60
C1Q	binds_to	gene	0.60
MICROGLIA	associated_with	gene	0.60
RS7529220	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ASTROCYTES	activates	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
GENETIC LOCI	associated_with	gene	0.60
C1Q	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found