Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PSMB9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PSMB9 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Aging, Als, Inflammation. Connected to 30 entities in the SciDEX knowledge graph.
| Gene Symbol | PSMB9 |
| Aliases | LMP2, LMP2i, RING12 |
| Chromosome | 6p21.33 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Immune tissues, Microglia, Brain |
| Molecular Weight | 23.2 kDa |
| Amino Acids | 10 aa |
| UniProt ID | P28065 |
| NCBI Gene ID | 5697 |
| Ensembl ID | ENSG00000240087 |
| OMIM | 177045 |
| GeneCards | PSMB9 |
| Human Protein Atlas | PSMB9 |
| Symbol [@ahmad2018] PSMB9 [@kotrschmar2019] [@cheroni2009] [@basler2014] Full Name | Proteasome Subunit Beta Type-9 |
| Also Known As | LMP2, LMP2i, RING12 |
| Associated Diseases | Aging, Als, Inflammation, Ms, Neurodegeneration, Neuropathy |
| KG Connections | 29 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PSMB9["<b>PSMB9</b>"]
Inflammation{"Inflammation"}
PSMB9 -->|"associated with"| Inflammation
Neuropathy{"Neuropathy"}
PSMB9 -->|"associated with"| Neuropathy
Neurodegeneration{"Neurodegeneration"}
PSMB9 -->|"associated with"| Neurodegeneration
Als{"Als"}
PSMB9 -->|"associated with"| Als
Ms{"Ms"}
PSMB9 -->|"associated with"| Ms
Aging{"Aging"}
PSMB9 -->|"associated with"| Aging
GNB4["GNB4"]
PSMB9 -->|"associated with"| GNB4
NEURODEGENERATION["NEURODEGENERATION"]
PSMB9 -->|"associated with"| NEURODEGENERATION
IL1B["IL1B"]
PSMB9 -->|"associated with"| IL1B
CCL5["CCL5"]
PSMB9 -->|"associated with"| CCL5
INFLAMMATION["INFLAMMATION"]
PSMB9 -->|"associated with"| INFLAMMATION
SQSTM1["SQSTM1"]
PSMB9 -->|"associated with"| SQSTM1
NFKB["NFKB"]
NFKB -->|"associated with"| PSMB9
BCL2["BCL2"]
BCL2 -->|"associated with"| PSMB9
AGING["AGING"]
AGING -->|"associated with"| PSMB9
style PSMB9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation | associated_with | disease | 0.65 |
| Neuropathy | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| GNB4 | associated_with | gene | 0.60 |
| IL1B | associated_with | gene | 0.60 |
| CCL5 | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| GBA | associated_with | gene | 0.60 |
| ENO1 | associated_with | gene | 0.60 |
| DDX5 | associated_with | gene | 0.60 |
| CD8 | associated_with | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| Proteasome | associated_with | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| Endocytosis | associated_with | pathway | 0.60 |
| NF-ΚB | associated_with | gene | 0.60 |
| Epigenetic | associated_with | pathway | 0.60 |
| Nf-Κb | associated_with | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||