gene

PSMB9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMB9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections
0Hypotheses
0Analyses
26Outgoing
3Incoming

Summary

PSMB9 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Aging, Als, Inflammation. Connected to 30 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolPSMB9
AliasesLMP2, LMP2i, RING12
Chromosome6p21.33
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionImmune tissues, Microglia, Brain
Molecular Weight23.2 kDa
Amino Acids10 aa
UniProt IDP28065
NCBI Gene ID5697
Ensembl IDENSG00000240087
OMIM177045
GeneCardsPSMB9
Human Protein AtlasPSMB9
Symbol [@ahmad2018] PSMB9 [@kotrschmar2019] [@cheroni2009] [@basler2014] Full NameProteasome Subunit Beta Type-9
Also Known AsLMP2, LMP2i, RING12
Associated DiseasesAging, Als, Inflammation, Ms, Neurodegeneration, Neuropathy
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: PSMB9 — AlphaFold P28065 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

PSMB9

gene · 1108 words

Proteasomal Pathway in Neurodegeneration

mechanism · 1803 words

PSMB9 Protein

protein · 1475 words

PSMB8

gene · 1370 words

PSMB7

gene · 1117 words

ENO1 Gene

gene · 1055 words

Pathway Diagram

graph TD
    PSMB9["<b>PSMB9</b>"]
    Inflammation{"Inflammation"}
    PSMB9 -->|"associated with"| Inflammation
    Neuropathy{"Neuropathy"}
    PSMB9 -->|"associated with"| Neuropathy
    Neurodegeneration{"Neurodegeneration"}
    PSMB9 -->|"associated with"| Neurodegeneration
    Als{"Als"}
    PSMB9 -->|"associated with"| Als
    Ms{"Ms"}
    PSMB9 -->|"associated with"| Ms
    Aging{"Aging"}
    PSMB9 -->|"associated with"| Aging
    GNB4["GNB4"]
    PSMB9 -->|"associated with"| GNB4
    NEURODEGENERATION["NEURODEGENERATION"]
    PSMB9 -->|"associated with"| NEURODEGENERATION
    IL1B["IL1B"]
    PSMB9 -->|"associated with"| IL1B
    CCL5["CCL5"]
    PSMB9 -->|"associated with"| CCL5
    INFLAMMATION["INFLAMMATION"]
    PSMB9 -->|"associated with"| INFLAMMATION
    SQSTM1["SQSTM1"]
    PSMB9 -->|"associated with"| SQSTM1
    NFKB["NFKB"]
    NFKB -->|"associated with"| PSMB9
    BCL2["BCL2"]
    BCL2 -->|"associated with"| PSMB9
    AGING["AGING"]
    AGING -->|"associated with"| PSMB9
    style PSMB9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

TargetRelationTypeStr
Inflammationassociated_withdisease0.65
Neuropathyassociated_withdisease0.65
Neurodegenerationassociated_withdisease0.65
Alsassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (3)

SourceRelationTypeStr
BCL2associated_withgene0.60
NFKBassociated_withgene0.60
AGINGassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found