Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Osteoarthritis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | AGING, ALOX5, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, APOE, APOPTOSIS |
| Therapeutic Agents | Perillaldehyde, α-Ketoglutarate |
| KG Connections | 356 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
graph TD
Osteoarthritis["<b>Osteoarthritis</b>"]
Inflammation{"Inflammation"}
Osteoarthritis -->|"therapeutic_target"| Inflammation
Als{"Als"}
Osteoarthritis -->|"therapeutic_target"| Als
Apoptosis["Apoptosis"]
Osteoarthritis -->|"therapeutic_target"| Apoptosis
Aging{"Aging"}
Osteoarthritis -->|"therapeutic_target"| Aging
INFLAMMATION(["INFLAMMATION"])
INFLAMMATION -->|"therapeutic_target"| Osteoarthritis
APOPTOSIS(["APOPTOSIS"])
APOPTOSIS -->|"therapeutic_target"| Osteoarthritis
AMPK(["AMPK"])
AMPK -->|"activates"| Osteoarthritis
style Osteoarthritis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Aging | associated_with | disease | 0.95 |
| Inflammation | associated_with | disease | 0.95 |
| Mtor | activates | pathway | 0.90 |
| Chondrocytes | associated_with | cell_type | 0.85 |
| Als | activates | disease | 0.85 |
| Als | associated_with | disease | 0.85 |
| Chondrocyte Senescence | associated_with | biological_process | 0.80 |
| Mtor | therapeutic_target | pathway | 0.80 |
| Autophagy | associated_with | pathway | 0.80 |
| Senescence | associated_with | pathway | 0.80 |
| Cancer | associated_with | disease | 0.75 |
| Apoptosis | activates | pathway | 0.70 |
| Mitophagy | activates | pathway | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| Mitophagy | regulates | pathway | 0.70 |
| Ferroptosis | activates | pathway | 0.70 |
| Ampk Signaling | activates | pathway | 0.70 |
| Oxidative Stress | therapeutic_target | pathway | 0.70 |
| Pi3K/Akt | therapeutic_target | pathway | 0.70 |
| Nf-Κb | therapeutic_target | pathway | 0.70 |
| Autophagy | treats | pathway | 0.70 |
| Mitophagy | implicated_in | pathway | 0.70 |
| Autophagy | implicated_in | pathway | 0.70 |
| Apoptosis | associated_with | pathway | 0.70 |
| Immune Response | therapeutic_target | pathway | 0.70 |
| Aging | contributes_to | disease | 0.65 |
| Osteoporosis | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Als | implicated_in | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Rheumatoid Arthritis | associated_with | disease | 0.65 |
| CHONDROCYTE | associated_with | cell_type | 0.64 |
| Mtor | treats | pathway | 0.60 |
| Oxidative Stress | treats | pathway | 0.60 |
| Mitochondrial Function | treats | pathway | 0.60 |
| Nf-Κb | activates | pathway | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| Pi3K/Akt | activates | pathway | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Cholesterol | associated_with | pathway | 0.60 |
| Cell Cycle | associated_with | pathway | 0.60 |
| Senescence | activates | pathway | 0.60 |
| Pyroptosis | activates | pathway | 0.60 |
| Oxidative Stress | regulates | pathway | 0.60 |
| Stem Cell | therapeutic_target | pathway | 0.60 |
| Microrna | regulates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| AMPK | activates | gene | 1.00 |
| ZBP1 | risk_factor_for | protein | 0.95 |
| Ageing | risk_factor_for | process | 0.95 |
| Mitophagy | involved_in | process | 0.95 |
| AGING | associated_with | gene | 0.95 |
| Inflammaging | contributes_to | mechanism | 0.90 |
| Iron Overload | risk_factor_for | process | 0.90 |
| SOD3 | protects_against | protein | 0.90 |
| PP2Ac | therapeutic_target | protein | 0.89 |
| PINK1 | therapeutic_target | gene | 0.88 |
| ALOX5 | associated_with | gene | 0.88 |
| Cellular Senescence | contributes_to | process | 0.88 |
| Perillaldehyde | treats | compound | 0.88 |
| PP2Ac | promotes | protein | 0.87 |
| NF-κB | regulates | pathway | 0.85 |
| Oxidative Stress | causes | process | 0.85 |
| Extracellular Matrix Degradation | causes | process | 0.85 |
| icariin | treats | drug | 0.85 |
| ROS | activates | gene | 0.85 |
| PI3K | activates | gene | 0.85 |
| AKT | therapeutic_target | gene | 0.85 |
| MTOR | therapeutic_target | gene | 0.85 |
| PI3K | therapeutic_target | gene | 0.85 |
| Rapamycin | protects_against | drug | 0.85 |
| Cell Apoptosis | contributes_to | process | 0.85 |
| AUTOPHAGY | associated_with | gene | 0.85 |
| Mitophagy Regulation | treats | mechanism | 0.80 |
| α-Ketoglutarate | treats | compound | 0.80 |
| PIEZO1 | causes | protein | 0.80 |
| Reduced AMPK Activity | contributes_to | mechanism | 0.80 |
| artemisinin | treats | drug | 0.80 |
| Sensory Nerve Regulation | associated_with | mechanism | 0.80 |
| Mitochondrial Quality Control | protects_against | process | 0.80 |
| JAK2 | causes | protein | 0.80 |
| STAT3 | causes | protein | 0.80 |
| Intercellular Mitochondrial Transfer | therapeutic_target | process | 0.80 |
| EXOSOMES | therapeutic_target | gene | 0.75 |
| MITOPHAGY | implicated_in | gene | 0.75 |
| AUTOPHAGY | implicated_in | gene | 0.75 |
| Intercellular Mitochondrial Transfer | treats | process | 0.75 |
| CYTOKINES | activates | gene | 0.75 |
| MIRNAS | therapeutic_target | gene | 0.75 |
| AGING | therapeutic_target | gene | 0.75 |
| Mesenchymal Stromal Cells | treats | cell_type | 0.75 |
| Diabetes | associated_with | disease | 0.75 |
| CANCER | therapeutic_target | gene | 0.75 |
| Tumor | therapeutic_target | disease | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity