concept

GLIOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLIOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

673Connections

0Hypotheses

3Analyses

50Outgoing

46Incoming

Summary

GLIOMA is a concept in neurodegeneration research. Key relationships include: co discussed, regulates, treats. Associated with ALZHEIMER, ALZHEIMER'S, CANCER. Connected to 32 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	GLIOMA
Key Genes/Proteins	IDH1, IDH2, PI3K
Related Diseases	TUMOR

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

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Pathway Diagram

graph TD
    GLIOMA["GLIOMA"]
    GLIOMA -->|"target for"| Autophagy["Autophagy"]
    GLIOMA -->|"regulates"| Cell_Cycle["Cell Cycle"]
    GLIOMA -->|"regulates"| Mtor["Mtor"]
    GLIOMA -->|"activates"| Complement["Complement"]
    GLIOMA -->|"activates"| Mapk["Mapk"]
    GLIOMA -->|"target for"| Akt["Akt"]
    GLIOMA -->|"target for"| Pi3K["Pi3K"]
    pericyte_senescence["pericyte senescence"] -->|"activates"| GLIOMA
    CBD["CBD"] -->|"treats"| GLIOMA
    TRPV4["TRPV4"] -.biomarker for.-> GLIOMA
    doxorubicin["doxorubicin"] -->|"treats"| GLIOMA
    mitophagy["mitophagy"] -->|"causes"| GLIOMA
    temozolomide["temozolomide"] -->|"treats"| GLIOMA
    cannabidiol["cannabidiol"] -->|"treats"| GLIOMA
    ATRX["ATRX"] -.biomarker for.-> GLIOMA
    BRAF["BRAF"] -.biomarker for.-> GLIOMA
    CIC["CIC"] -.biomarker for.-> GLIOMA

Outgoing (245)

Target	Relation	Type	Str
PERICYTE	causes	cell_type	0.65
PERICYTE	contributes_to	cell_type	0.65
MACROPHAGE	mediates	cell_type	0.65
MACROPHAGE	promotes	cell_type	0.65
MACROPHAGES	promotes	cell_type	0.65
PI3K	promotes	gene	0.65
PI3K	activates	gene	0.65
TUMOR	reduces	disease	0.65
T CELL	expressed_in	cell_type	0.65
STING	reduces	gene	0.65
LACTATE	interacts_with	phenotype	0.65
APP	produces	gene	0.65
TUMOR	causes	disease	0.60
TUMOR	associated_with	disease	0.60
T CELL	activates	cell_type	0.60
MACROPHAGE	expressed_in	cell_type	0.60
MACROPHAGES	expressed_in	cell_type	0.60
MACROPHAGE	treats	cell_type	0.60
MACROPHAGES	treats	cell_type	0.60
MACROPHAGE	regulates	cell_type	0.60
MAPK	causes	gene	0.60
TUMOR	regulates	disease	0.60
NEURON	promotes	cell_type	0.60
NEURONS	causes	cell_type	0.60
NEURON	regulates	cell_type	0.60
TUMOR	promotes	disease	0.60
MACROPHAGES	mediates	cell_type	0.60
HUNTINGTON	associated_with	disease	0.60
HUNTINGTON'S	associated_with	disease	0.60
SCHIZOPHRENIA	associated_with	disease	0.60
PI3K	contributes_to	gene	0.60
PI3K	regulates	gene	0.60
VEGF	activates	gene	0.60
VEGF	contributes_to	gene	0.60
TUMOR	inhibits	disease	0.60
PDGF	causes	gene	0.60
MACROPHAGE	associated_with	cell_type	0.60
MACROPHAGES	associated_with	cell_type	0.60
MICROGLIA	associated_with	cell_type	0.60
MACROPHAGE	activates	cell_type	0.60
MACROPHAGES	activates	cell_type	0.60
MICROGLIA	activates	cell_type	0.60
MACROPHAGES	synergizes_with	cell_type	0.60
MICROGLIA	expressed_in	cell_type	0.55
PPARA	associated_with	gene	0.50
APP	associated_with	gene	0.50
CORTEX	associated_with	brain_region	0.45
AKT	associated_with	gene	0.45
MAPK	associated_with	gene	0.45
BAX	associated_with	gene	0.45

Incoming (428)

Source	Relation	Type	Str
IDH1	associated_with	entity	0.98
IDH2	associated_with	entity	0.98
IDH1	mutated_in	gene	0.90
IDH2	mutated_in	gene	0.90
STRESS GRANULES	associated_with	entity	0.80
SENESCENCE	modulates	entity	0.75
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
AKT	promotes	gene	0.65
GLIOBLASTOMA	reduces	disease	0.65
CANCER	increases	disease	0.65
EGFR	targets	gene	0.65
EGFR	produces	gene	0.65
NEURON	inhibits	cell_type	0.65
CANCER	promotes	disease	0.60
CANCER	inhibits	disease	0.60
CANCER	treats	disease	0.60
ACHE	targets	gene	0.60
GLIOBLASTOMA	mediates	disease	0.60
CANCER	causes	disease	0.60
AMPK	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.60
DEMENTIA	associated_with	disease	0.60
EPILEPSY	associated_with	disease	0.60
ASTROCYTES	expressed_in	cell_type	0.60
AKT	contributes_to	gene	0.60
BAX	activates	gene	0.60
CORTEX	expressed_in	brain_region	0.60
CYP46A1	expressed_in	gene	0.60
CANCER	converts	disease	0.60
AKT	implicated_in	gene	0.55
EGFR	expressed_in	gene	0.55
METASTASIS	expressed_in	phenotype	0.55
TEMOZOLOMIDE	associated_with	drug	0.45
MTOR SIGNALING	associated_with	pathway	0.45
MAPK PATHWAY	associated_with	pathway	0.45
PI3K/AKT PATHWAY	associated_with	pathway	0.45
GLIOBLASTOMA	co_discussed	disease	0.40
CANCER	co_discussed	disease	0.40
ALZHEIMER	co_discussed	disease	0.40
ALZHEIMER'S	co_discussed	disease	0.40
CARCINOMA	co_discussed	disease	0.40
BRAINSTEM	co_discussed	brain_region	0.40
ERK	co_discussed	gene	0.40
ALS	co_discussed	disease	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GLIOMA

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

HNRNPA2B1 Protein

amyloid-beta-metalloproteinases

Blood-Brain Barrier Biology and Crossing Strategies

nf1-protein

Pathway Diagram

Outgoing (245)

Incoming (428)

Targeting Hypotheses (0)

Mentioning Analyses (3)

How does pericyte senescence mechanistically promote glioma cell growth and inva

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

Related Papers (0)

GLIOMA

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

HNRNPA2B1 Protein

amyloid-beta-metalloproteinases

Blood-Brain Barrier Biology and Crossing Strategies

nf1-protein

Litronesib (LY317615/Enzastaurin)

GLI1 — GLI Family Zinc Finger 1

PAK2 Protein (p21-Activated Kinase 2)

IL1RAP — Interleukin-1 receptor accessory protein

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

NSUN2 Gene

TNR Gene — Tenascin R

Stress Granules in Neurodegeneration

PLAU Gene (Urokinase)

Blood-Brain Barrier

Hedgehog Signaling in Neurodegeneration

Anti-CASPR2 Encephalitis-Affected Neurons

NanoCarrier Co., Ltd.

H3F3B Gene — H3.3 Histone B

Bulbar Palsy

Pathway Diagram

Outgoing (245)

Incoming (428)

Targeting Hypotheses (0)

Mentioning Analyses (3)

How does pericyte senescence mechanistically promote glioma cell growth and inva

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

Related Papers (0)