concept

AXON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AXON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1150Connections

5Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

AXON is a concept in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 388 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	AXON
Key Genes/Proteins	NEURON, CANCER, NEURODEGENERATION
Related Diseases	Als, Cancer, Neurodegeneration, ALS, Inflammation
Linked Hypotheses	6 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Corticobasal Syndrome (CBS)

disease · 11374 words

→

Pathway Diagram

graph TD
    AXON["AXON"]
    AXON -->|"causes"| ALS["ALS"]
    AXON -->|"activates"| Cancer["Cancer"]
    AXON -->|"causes"| Inflammation["Inflammation"]
    AXON -->|"causes"| Aging["Aging"]
    AXON -->|"activates"| Neuroinflammation["Neuroinflammation"]
    AXON -->|"stabilizes"| JUN["JUN"]
    AXON -->|"expressed in"| NEURON["NEURON"]
    CDK5["CDK5"] -->|"causes"| AXON
    CANCER["CANCER"] -->|"activates"| AXON
    HIPPO["HIPPO"] -->|"activates"| AXON
    G3BP1["G3BP1"] -->|"activates"| AXON
    NEURON -->|"activates"| AXON
    INFLAMMATION["INFLAMMATION"] -->|"causes"| AXON
    HSP90["HSP90"] -->|"activates"| AXON
    ROS["ROS"] -->|"activates"| AXON

Outgoing (699)

Target	Relation	Type	Str
Als	activates	disease	0.95
Cancer	activates	disease	0.85
Neurodegeneration	causes	disease	0.85
NEURON	causes	gene	0.80
NEURON	activates	gene	0.80
CANCER	activates	gene	0.80
NEURODEGENERATION	causes	gene	0.80
ALS	causes	disease	0.75
Inflammation	activates	disease	0.75
Tumor	activates	disease	0.75
Amyotrophic Lateral Sclerosis	activates	disease	0.75
Alzheimer	activates	disease	0.75
Parkinson	regulates	disease	0.75
Alzheimer	regulates	disease	0.75
Multiple Sclerosis	associated_with	disease	0.75
Als	regulates	disease	0.75
NEURON	associated_with	gene	0.70
AKT	activates	gene	0.70
TRAK1	interacts_with	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
Oxidative Stress	activates	pathway	0.70
AXON REGENERATION	associated_with	gene	0.70
Mapk	activates	pathway	0.70
AKT	regulates	gene	0.70
MICROGLIA	associated_with	gene	0.70
BRAIN INJURY	associated_with	gene	0.70
AXON REGENERATION	activates	gene	0.70
DNA	activates	gene	0.70
MTOR	associated_with	gene	0.70
Mtor	associated_with	pathway	0.70
ALZHEIMER	activates	gene	0.70
NEURODEGENERATIVE DISEASES	associated_with	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.70
PARKINSON	regulates	gene	0.70
ALZHEIMER	regulates	gene	0.70
Differentiation	regulates	pathway	0.70
ASTROCYTE	associated_with	gene	0.70
ASTROCYTES	activates	gene	0.70
TAU	associated_with	gene	0.65
MYELIN	associated_with	gene	0.65
ALS	activates	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	causes	disease	0.65
Aging	causes	disease	0.65
ALS	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Ms	activates	disease	0.65
Als	protects_against	disease	0.65

Incoming (451)

Source	Relation	Type	Str
TAU	expressed_in	entity	0.90
NAD	activates	gene	0.70
NAD	regulates	gene	0.70
SARM1	activates	gene	0.70
AKT	co_discussed	gene	0.60
ACHE	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
CDK5	causes	gene	0.60
AXON REGENERATION	associated_with	gene	0.60
KCNMA1	associated_with	gene	0.60
KCNQ1	associated_with	gene	0.60
PIEZO1	associated_with	gene	0.60
CANCER	activates	gene	0.60
HIPPO	activates	gene	0.60
CFTR	associated_with	gene	0.60
SCN1A	associated_with	gene	0.60
TRPA1	associated_with	gene	0.60
KCNN4	associated_with	gene	0.60
G3BP1	activates	gene	0.60
NEURON	activates	gene	0.60
INFLAMMATION	causes	gene	0.60
HSP90	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ROS	activates	gene	0.60
NEURON	expressed_in	gene	0.60
REELIN	causes	gene	0.60
NEURON	causes	gene	0.60
DCX	causes	gene	0.60
EXOSOMES	activates	gene	0.60
NTN1	associated_with	gene	0.60
AKT	activates	gene	0.60
KCNK2	associated_with	gene	0.60
TCR	associated_with	gene	0.60
DYNACTIN	interacts_with	gene	0.60
NEURON	associated_with	gene	0.60
TRAK1	interacts_with	gene	0.60
APOPTOSIS	activates	gene	0.60
APOPTOSIS	protects_against	gene	0.60
KRAS	activates	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ERK	associated_with	gene	0.60
MERTK	inhibits	gene	0.60
GFP	inhibits	gene	0.60
CGAS-STING	associated_with	gene	0.60
CGAS	activates	gene	0.60
STING	activates	gene	0.60
STAT3	activates	gene	0.60
GENES	activates	gene	0.60
CALCINEURIN	regulates	gene	0.60

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across
STMN2 Restoration as a Prerequisite for Axon Growth After TD	0.658	neurodegeneration	What molecular mechanisms enable functio
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D	0.614	neurodegeneration	What is the molecular mechanism by which
Granzyme B Inhibition with Serpina3n to Preserve Axonal Inte	0.514	neuroimmunology	Do CXCL10-recruited CD8+ T cells provide
Axonal RNA Transport Reconstitution	0.446	neurodegeneration	RNA binding protein dysregulation across

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966]	Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X	Theranostics	2023	1
Multisystem proteinopathy: Where myopathy and motor neuron disease converge. [PMID:33145792]	Korb MK, Kimonis VE, Mozaffar T	Muscle Nerve	2021	1
The role of m6A modification in the biological functions and diseases. [PMID:33611339]	Jiang X, Liu B, Nie Z, Duan L, Xiong Q,	Signal Transduct Target Ther	2021	1
Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liv [PMID:33213490]	Senlin Zhao, Yushuai Mi, Bingjie Guan, B	Journal of hematology & oncolo	2020	1
Rare Inherited forms of Paget's Disease and Related Syndromes. [PMID:30756140]	Ralston SH, Taylor JP	Calcif Tissue Int	2019	1
A LNK-CBL-HNRPA2B1-GPX4 signaling axis mediates dopaminergic neuron vulnerabilit [PMID:41616574]	["Liu Z", "Wang R", "Shen M", "Lan X", "	Redox biology	2026	0
Human papillomavirus 16 E6 oncoprotein promotes up-regulation of RNA-binding pro [PMID:41725810]	["Cerasuolo A", "Pecchillo Cimmino T", "	Frontiers in microbiology	2026	0
Molecular recognition and induced dimerization of hnRNP A2/B1 truncations by G-q [PMID:41888191]	["Shahatibieke D", "Tang X", "Zheng X",	Scientific reports	2026	0
Coordinated Post-Transcriptional Regulation facilitates PD-L1 protein production [PMID:41936857]	Chen R, Rajasekaran S, Xing X, Zhang Q,	Cancer Lett	2026	0
LncRNA 4930544M13Rik-201 regulates CACNA2D1 expression via interacting with hnRN [PMID:41864512]	Fang Z, Liu F, Tang Q, Liu Y, Peng Y, Zh	Brain research bulletin	2026	0
Comparative Binding Analysis by Computational Methods and Quartz Crystal Microba [PMID:41728844]	["Volkova O", "Serova A", "Kravtsov V",	Journal of chemical informatio	2026	0
Functional Variants of the RAD51 Gene Contribute to Susceptibility to Non-Syndro [PMID:41918261]	Guo S, Guo T, Xu Y, Chen R, Wang X	Orthodontics & craniofacial re	2026	0
Ligand-specific conformational dynamics and interaction landscapes of hnRNPA2B1 [PMID:41853685]	Zhou Z, Li Y, Yang P, Zhu R, Li J, Wu B,	Current research in structural	2026	0
Neddylation-Mediated hnRNPA2B1 Degradation Aggravates Retinal Endothelial Cell D [PMID:41773772]	Chen TR, Zhou JX, Hou YR, Zhang YN, Li C	Investigative ophthalmology &	2026	0
Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition o [PMID:41662154]	["Park R", "Demny M", "Miller L", "Pedra	RNA biology	2026	0
Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP [PMID:41787499]	Xu C, Zhou Z, Lin Y, Zhang S, Cai S, Li	Journal of translational medic	2026	0
Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergi [PMID:41507195]	["Jin Y", "Cao Y", "Ma W", "Li R", "Li Y	Nature communications	2026	0
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatic [PMID:41725222]	["Xu W", "Shi L", "Lu A", "Cui L", "Qian	Immunity, inflammation and dis	2026	0
Expression, purification, and biophysical characterization of liquid-liquid phas [PMID:41297573]	["Dur\u00e1n-Armenta L", "Meszaros A", "	Protein expression and purific	2026	0
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progre [PMID:34453888]	Jiang L, Lin W, Zhang C, Ash PEA, Verma	Molecular cell	2021	0

AXON

Understanding Entity Pages

Summary

Wiki Pages (21)

blarcamesine-axon

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Pathway Diagram

Outgoing (699)

Incoming (451)

Targeting Hypotheses (5)

Mentioning Analyses (3)

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What signals trigger microglia to specifically recognize and phagocytose LC axon

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

Related Papers (20)

AXON

Understanding Entity Pages

Summary

Wiki Pages (21)

blarcamesine-axon

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Parthanatos in Neurodegeneration

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PD Combination Therapy Matrix

Alzheimer's Disease Mechanism Index

Corticobasal Degeneration (CBD)

nimodipine-als

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

Multiple System Atrophy

Alzheimer's Disease

Pathway Diagram

Outgoing (699)

Incoming (451)

Targeting Hypotheses (5)

Mentioning Analyses (3)

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What signals trigger microglia to specifically recognize and phagocytose LC axon

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

Related Papers (20)