TRIM32

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM32: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TRIM32 (Tripartite Motif Containing 32) - E3 ubiquitin ligase involved in mitochondrial quality control, protein homeostasis, and neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS

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graph TD
    TRIM32["<b>TRIM32</b>"]
    STING["STING"]
    TRIM32 -->|"modifies"| STING
    Carcinoma{"Carcinoma"}
    TRIM32 -->|"activates"| Carcinoma
    Als{"Als"}
    TRIM32 -->|"activates"| Als
    Tumor{"Tumor"}
    TRIM32 -->|"activates"| Tumor
    Inflammation{"Inflammation"}
    TRIM32 -->|"activates"| Inflammation
    Ms{"Ms"}
    TRIM32 -->|"activates"| Ms
    P62["P62"]
    TRIM32 -->|"activates"| P62
    CD8["CD8"]
    TRIM32 -->|"activates"| CD8
    NBR1["NBR1"]
    TRIM32 -->|"interacts with"| NBR1
    INFLAMMATION["INFLAMMATION"]
    TRIM32 -->|"activates"| INFLAMMATION
    BRCA1["BRCA1"]
    TRIM32 -->|"interacts with"| BRCA1
    TRIM32 -->|"activates"| STING
    NBR1 -->|"inhibits"| TRIM32
    PIN1["PIN1"]
    PIN1 -->|"phosphorylates"| TRIM32
    TLR4["TLR4"]
    TLR4 -->|"interacts with"| TRIM32
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"interacts with"| TRIM32
    CASP8["CASP8"]
    CASP8 -->|"activates"| TRIM32
    style TRIM32 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0