gene

alox15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about alox15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

377Connections

2Hypotheses

0Analyses

1Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ALOX15
Full Name	ALOX15 - Arachidonate 15-Lipoxygenase
Aliases	Arachidonate 15-Lipoxygenase
Chromosome	17p13.2
Protein Type	Gene
Target Class	Enzyme
Function	The enzyme contains a non-heme iron center essential for its catalytic activity and requires iron for proper folding and function.
Mechanism of Action	Small molecule inhibitors targeting the active site iron and substrate binding
Primary Expression	various tissues including: [@zhang2020] - Brain: Astrocytes, microglia, and cer
Druggability	Low (0.38)
Clinical Stage	Approved
Molecular Weight	~75 kDa
Pathways	Allosteric Binding, Allosteric Binding Sites, Enzyme Dimers, Enzyme Monomer Subunits, Nf-Kb
UniProt ID	P16050
NCBI Gene ID	Search NCBI
GeneCards	ALOX15
Human Protein Atlas	ALOX15
Associated Diseases	ALS, Cancer, Cardiovascular, Cardiovascular Diseases, Fibrosis
Known Drugs/Compounds	omega-6 fatty acids, omega-3 fatty acids
Interactions	GSDMD, SCD1, HMGCR, TNF, MLKL, ACSL4
SciDEX Target	View Target Profile (7 clinical trials)
SciDEX Hypotheses	ALOX15-Driven Enzymatic Ferroptosis in AD Oligoden Astrocytic Lipoxin A4 Pathway Restoration via ALOX
KG Connections	374 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: alox15 — AlphaFold P16050 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ALOX15["ALOX15"]
    ALOX15 -->|"interacts"| Als["Als"]
    ALOX15 -->|"activates"| Cancer["Cancer"]
    ALOX15 -->|"activates"| Cardiovascular["Cardiovascular"]
    ALOX15 -->|"activates"| Ischemia["Ischemia"]
    ALOX15 -->|"inhibits"| Cardiac["Cardiac"]
    ALOX15 -->|"activates"| Ms["Ms"]
    ALOX15 -->|"activates"| Fibrosis["Fibrosis"]
    ALOX15 -->|"inhibits"| Inflammation["Inflammation"]
    ALOX15 -->|"inhibits"| Hepatitis["Hepatitis"]
    h_ac55ff26["h-ac55ff26"] -->|"target for"| ALOX15
    DHODH["DHODH"] -->|"inhibits"| ALOX15
    ALOX5["ALOX5"] -->|"contributes to"| ALOX15
    ALOX12["ALOX12"] -->|"contributes to"| ALOX15
    GAIN["GAIN"] -->|"activates"| ALOX15
    FASN["FASN"] -->|"inhibits"| ALOX15
    BAX["BAX"] -->|"inhibits"| ALOX15
    USP7["USP7"] -->|"inhibits"| ALOX15
    HNRNPA1["HNRNPA1"] -->|"inhibits"| ALOX15

Outgoing (270)

Target	Relation	Type	Str
neurodegeneration	implicated_in	disease	0.50

Incoming (107)

Source	Relation	Type	Str
MIR125B	targets	biomarker	0.90
omega-6 fatty acids	interacts_with	compound	0.90
omega-3 fatty acids	interacts_with	compound	0.90
h-ac55ff26	targets_gene	hypothesis	0.90
h-var-97b18b880d	targets_gene	hypothesis	0.90
Liproxstatin-1	downregulates	drug	0.85
Mir-522	inhibits	biomarker	0.85
MIR125B	inhibits	gene	0.85
ALOX5	associated_with	gene	0.85
ALOXE3	associated_with	gene	0.85
h-ac55ff26	targets	hypothesis	0.80
Mir125B	targets	biomarker	0.80
FERROPTOSIS	activates	gene	0.70
ALOX12	co_mentioned_with	gene	0.60
LOX	associated_with	gene	0.60
ALOX5	contributes_to	gene	0.60
ALOX12	contributes_to	gene	0.60
GAIN	activates	gene	0.60
FASN	inhibits	gene	0.60
BAX	inhibits	gene	0.60
USP7	inhibits	gene	0.60
HNRNPA1	inhibits	gene	0.60
LOX	regulates	gene	0.60
VDR	regulates	gene	0.60
ALOX5	activates	gene	0.60
HMOX1	activates	gene	0.60
ACSL4	inhibits	gene	0.60
TNF	inhibits	gene	0.60
SCD1	inhibits	gene	0.60
HMGCR	inhibits	gene	0.60
GSDMD	inhibits	gene	0.60
MLKL	inhibits	gene	0.60
ALOX12	activates	gene	0.60
FER	activates	gene	0.60
NFE2L2	activates	gene	0.60
UBIQUITIN	causes	gene	0.60
UBIQUITIN	inhibits	gene	0.60
SLC7A11	activates	gene	0.60
NOX4	activates	gene	0.60
JNK	activates	gene	0.60
P38	activates	gene	0.60
ALOX12	associated_with	entity	0.60
UBIQUITIN	activates	gene	0.60
ALOX12	implicated_in	gene	0.60
ACSL4	biomarker_for	gene	0.60
ALOX12	inhibits	gene	0.60
GENES	associated_with	gene	0.60
GENES	contributes_to	gene	0.60
ALOX	interacts_with	gene	0.60
GENES	inhibits	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th	0.455	neurodegeneration	Neuroinflammation resolution mechanisms

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134]	Yang J, Borchert A, Kuhn H	J Biol Chem	2026	1
Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924]	Cai W, Liu L, Shi X, Liu Y, Wang J, Fang	Circulation	2023	1
Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829]	Tong J, Lan XT, Zhang Z, Liu Y, Sun DY,	Acta Pharmacol Sin	2023	1
CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859]	Zhang H, Deng T, Liu R, Ning T, Yang H,	Mol Cancer	2020	1
Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102]	Zhao Y, Bhattacharjee S, Jones BM, Hill	Mol Neurobiol	2014	1
ALOX15 exerts tumor-suppressive role in head and neck squamous cell carcinoma vi [PMID:41820595]	Liu A, Zhang X, Li R, Zhang Y, Yang Z, Z	Functional & integrative genom	2026	0
Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 C [PMID:41589658]	Hou G, Luan J, Xu X, Qin J, Ma S et al.	Adv Sci (Weinh)	2026	0
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026	0
Sanhua essential oil exerts antidepressant effects in breast cancer-related depr [PMID:41722126]	Li X, Xu Z, Ju P, Dong M, Wang Y et al.	Phytomedicine	2026	0
Isorhamnetin-preconditioned MSC-derived exosomes restore ovarian function by inh [PMID:41947243]	Zhang Q, Yu J, Zheng Y, Jiang J, Zheng L	Stem Cell Res Ther	2026	0
Immune dysregulation in fibromyalgia: Targeting the NLRP3 inflammasome-ferroptos [PMID:41962813]	Fawzy MN, Badawi GA, El-Sayed RM	Clin Immunol	2026	0
Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Develop [PMID:41750540]	Man GCW, Borchert A, Zhang T, Hung SW, K	Antioxidants (Basel, Switzerla	2026	0
ALOX15-Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq-P [PMID:41847922]	Hilman A, Ishii Y, Wijatniko BD, Rini DM	FASEB journal : official publi	2026	0
Cigarette Smoke Exacerbates Pressure Overload-Induced Right Ventricular Dysfunct [PMID:41746293]	Zhou L, Bai Q, Shi R, Zeng X, Deng J, Lu	FASEB journal : official publi	2026	0
FGF21 promotes the resolution of inflammation through the ALOX15/SPM pathway in [PMID:41913238]	Shen C, Cao Y, Wei J, Tian X, Zhang C, W	Respiratory research	2026	0
Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic do [PMID:39882747]	Deng S, Cao H, Li T, Wang X, Meng J, Zen	Gut microbes	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
FGF21 modulates immunometabolic homeostasis via the ALOX15/15-HETE axis in early [PMID:39362839]	Yang X, Chen H, Shen W, Chen Y, Lin Z, Z	Nature communications	2024	0
Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer ba [PMID:37469520]	Shen L, Huang H, Li J, Chen W, Yao Y, Hu	Frontiers in immunology	2023	0
A survey of human brain transcriptome diversity at the single cell level. [PMID:26060301]	["Darmanis S", "Sloan S", "Zhang Y", "En	Proceedings of the National Ac	2015	0

alox15

Understanding Entity Pages

Wiki Pages (21)

ALOX15 - Arachidonate 15-Lipoxygenase

NPM1 Gene

neuroinflammation

DDX3X Gene

Ferroptosis in Neurodegeneration

DDB2 Gene

TOR1A Gene

YME1L1 Gene

CNTFR Gene

PTCH2 Gene

MS4A4A Gene — Membrane-Spanning 4-Domains A4A

Ferroptotic Neurons

ROCK1 Gene

PP2A Tau Phosphatase Pathway

PEX13 Gene

Neuroinflammation Pathway

NSUN2 Gene

DNA Damage Response in Corticobasal Syndrome

HNRNPA1 Protein