Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AUTOPHAGOSOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AUTOPHAGOSOME |
| Key Genes/Proteins | P2RY12, SQSTM1, MAP1LC3, ABCA1, ABCG1, ACTB |
| Related Diseases | atherosclerosis |
| Related Pathways | Cholesterol |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
AUTOPHAGOSOME["AUTOPHAGOSOME"]
AUTOPHAGOSOME -->|"inhibits"| LYSOSOME["LYSOSOME"]
AUTOPHAGOSOME -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGOSOME -->|"activates"| P62["P62"]
AUTOPHAGOSOME -->|"activates"| LC3["LC3"]
CALCOCO2["CALCOCO2"] -->|"involved_in"| AUTOPHAGOSOME
ATTEC["ATTEC"] -->|"targets"| AUTOPHAGOSOME
ATG7["ATG7"] -->|"activates"| AUTOPHAGOSOME
SQSTM1["SQSTM1"] -->|"activates"| AUTOPHAGOSOME
ATG5["ATG5"] -->|"activates"| AUTOPHAGOSOME
APP["APP"] -->|"inhibits"| AUTOPHAGOSOME
ATHEROSCLEROSIS["ATHEROSCLEROSIS"] -->|"activates"| AUTOPHAGOSOME
AMPK["AMPK"] -->|"activates"| AUTOPHAGOSOME| Target | Relation | Type | Str |
|---|---|---|---|
| CEREBRAL CORTEX | inhibits | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| P2RY12 | activates | gene | 0.50 |
| SQSTM1 | activates | gene | 0.50 |
| MAP1LC3 | activates | gene | 0.50 |
| ABCA1 | activates | gene | 0.50 |
| ABCG1 | activates | gene | 0.50 |
| ACTB | activates | gene | 0.50 |
| APOA1 | activates | gene | 0.50 |
| Autophagy | activates | process | 0.50 |
| ULK1 | activates | gene | 0.50 |
| EIF4EBP1 | activates | gene | 0.50 |
| 4E-BP1 | activates | protein | 0.50 |
| Cholesterol | activates | pathway | 0.50 |
| atherosclerosis | activates | disease | 0.50 |
| Autophagy | interacts_with | process | 0.50 |
| ULK1 | interacts_with | gene | 0.50 |
| BECN1 | interacts_with | gene | 0.50 |
| PIK3C3 | interacts_with | gene | 0.50 |
| SQSTM1 | associated_with | gene | 0.50 |
| STX17 | associated_with | gene | 0.50 |
| LYSOSOME | associated_with | gene | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| SNARE | associated_with | protein | 0.50 |
| Autophagy | regulates | process | 0.50 |
| SNARE | regulates | protein | 0.50 |
| LYSOSOME | regulates | gene | 0.50 |
| Proteins | regulates | protein | 0.50 |
| SNAP29 | associated_with | gene | 0.50 |
| VAMP7 | associated_with | gene | 0.50 |
| VAMP8 | associated_with | gene | 0.50 |
| STX17 | regulates | gene | 0.50 |
| mitophagy | regulates | pathway | 0.50 |
| GABA | activates | gene | 0.50 |
| SNAP29 | activates | gene | 0.50 |
| RAB2A | activates | gene | 0.50 |
| mTOR | activates | entity | 0.50 |
| GABARAPL1 | activates | gene | 0.50 |
| MAP1LC3B | activates | gene | 0.50 |
| PRKN | activates | gene | 0.50 |
| RB1CC1 | activates | gene | 0.50 |
| RTN3 | activates | gene | 0.50 |
| STX17 | activates | gene | 0.50 |
| VAMP7 | activates | gene | 0.50 |
| VAMP8 | activates | gene | 0.50 |
| LAMP2 | activates | protein | 0.50 |
| SNARE | activates | protein | 0.50 |
| RUBICON | activates | protein | 0.50 |
| UBIQUITIN | activates | protein | 0.50 |
| RAB7A | activates | protein | 0.50 |
| GABARAP | activates | protein | 0.50 |
| DNM1L | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso | 0.542 | neurodegeneration | What molecular mechanisms link elevated |
| Autophagosome Maturation Checkpoint Control | 0.494 | neurodegeneration | Autophagy-lysosome pathway convergence a |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276] | Voicu V, Toader C, Șerban M, Covache-Bus | Biomedicines | 2025 | 1 |
| Acetylation in the regulation of autophagy. [PMID:35435793] | Xu Y, Wan W | Autophagy | 2023 | 1 |
| New insights regarding SNARE proteins in autophagosome-lysosome fusion. [PMID:32924745] | Tian X, Teng J, Chen J | Autophagy | 2021 | 1 |
| Autophagosomes form at ER-mitochondria contact sites. [PMID:23455425] | Hamasaki M, Furuta N, Matsuda A, Nezu A, | Nature | 2013 | 1 |
| SNX16 functions as a nutrient-sensitive regulator of autophagosomal components r [PMID:41593027] | Que H, Rong Y | Autophagy | 2026 | 0 |
| Downhill Running Blocks the Mitophagic Flux and Autophagosome-Lysosome Fusion in [PMID:41630123] | Deng H, Zheng S, Li M, Zhang D, Yang T, | Medicine and science in sports | 2026 | 0 |
| Rapid optogenetic manipulation of autophagy reveals that the nuclear pore comple [PMID:41676542] | Mondal P, Cyril A, Parham L, Mamriev D, | bioRxiv : the preprint server | 2026 | 0 |
| NK cell-derived GZMB (granzyme B) suppresses glioblastoma radioresistance by blo [PMID:41378763] | Yan J, Feng R, Qin Q, Shen G, Tian M, Li | Autophagy | 2026 | 0 |
| Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-medi [PMID:40327696] | ["Dash B", "Urano Y", "Mita Y", "Ashida | Proceedings of the National Ac | 2025 | 0 |
| CD147 promotes NSCLC metastasis by inducing secretory autophagy-dependent exosom [PMID:41413248] | Yang J, Liao C, Liang X, Ke Y, Sun Y, Hu | Cell death and differentiation | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pat [PMID:33632058] | ["Beckers J", "Tharkeshwar A", "Van Damm | Autophagy | 2021 | 0 |
| Automated Software System to Promote Anticoagulation and Reduce Stroke Risk: Clu [PMID:28119433] | ["Holt T", "Dalton A", "Marshall T", "Fa | Stroke | 2017 | 0 |
| Evolutionarily conserved role and physiological relevance of a STX17/Syx17 (synt [PMID:24113031] | ["Heged\u0171s K", "Tak\u00e1ts S", "Kov | Autophagy | 2013 | 0 |
| Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function. [PMID:23791177] | ["Buchan J", "Kolaitis R", "Taylor J", " | Cell | 2013 | 0 |
| Actinic lichen nitidus. [PMID:25386247] | ["Blalock T", "Kannan S", "Davis L"] | Dermatology reports | 2010 | 0 |