concept

SELECTIVE AUTOPHAGY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SELECTIVE AUTOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

173Connections

0Hypotheses

1Analyses

7Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SELECTIVE AUTOPHAGY
Key Genes/Proteins	TFEB, PPARGC1A, STIP1, TARDBP, BECN1, SQSTM1

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SELECTIVE_AUTOPHAGY["SELECTIVE AUTOPHAGY"]
    style SELECTIVE_AUTOPHAGY fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    SELECTIVE_AUTOPHAGY -->|"targets"| PEDV_N_protein([PEDV N protein])
    SELECTIVE_AUTOPHAGY -.->|"degrades"| PEDV_N([PEDV N])
    SELECTIVE_AUTOPHAGY -.->|"protects against"| Neurodegeneration["Neurodegeneration"]
    SELECTIVE_AUTOPHAGY -.->|"inhibits"| STAT2([STAT2])
    SELECTIVE_AUTOPHAGY -->|"component_of"| Mitophagy["Mitophagy"]
    SELECTIVE_AUTOPHAGY -->|"component_of"| Xenophagy["Xenophagy"]
    SELECTIVE_AUTOPHAGY -->|"component_of"| Aggrephagy["Aggrephagy"]
    SELECTIVE_AUTOPHAGY -->|"involved_in"| Cancer["Cancer"]
    SELECTIVE_AUTOPHAGY -->|"involved_in"| Mitochondria["/Mitochondria/"]
    SELECTIVE_AUTOPHAGY -->|"mediates"| Protein_Degradation["Protein Degradation"]
    ULK1([ULK1]) -->|"involved_in"| SELECTIVE_AUTOPHAGY
    SQSTM1([SQSTM1]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    SQSTM1G427R([SQSTM1G427R]) -.->|"inhibits"| SELECTIVE_AUTOPHAGY
    TOLLIP([TOLLIP]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    CALCOCO2([CALCOCO2]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    Parkin([Parkin]) -->|"activates"| SELECTIVE_AUTOPHAGY
    PRKN([PRKN]) -->|"activates"| SELECTIVE_AUTOPHAGY
    NDP52([NDP52]) -->|"participates in"| SELECTIVE_AUTOPHAGY
    Ubiquitin_Phosphorylation["Ubiquitin Phosphorylation"] -->|"mediates"| SELECTIVE_AUTOPHAGY

Outgoing (33)

Target	Relation	Type	Str
STEM CELLS	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
PEROXISOME	activates	concept	0.50
AUTOPHAGOSOME	interacts_with	concept	0.50
α-SYNUCLEIN	protects_against	concept	0.50
AUTOPHAGOSOME	associated_with	concept	0.50
ENDOPLASMIC RETICULUM	associated_with	concept	0.50

Incoming (140)

Source	Relation	Type	Str
TFEB	activates	protein	0.50
Autophagy	activates	process	0.50
PPARGC1A	activates	gene	0.50
STIP1	activates	gene	0.50
TARDBP	activates	gene	0.50
BECN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
mTOR	activates	entity	0.50
MAP1LC3B	activates	gene	0.50
MCOLN1	activates	gene	0.50
BAG3	activates	gene	0.50
TREH	activates	gene	0.50
GAPDH	activates	gene	0.50
HSPB8	activates	gene	0.50
Sod1	activates	gene	0.50
CTSB	activates	gene	0.50
PPP3CB	activates	gene	0.50
LAMP2A	activates	gene	0.50
BCL2	activates	gene	0.50
HSPA8	activates	gene	0.50
TPP1	activates	gene	0.50
TARDBP/TDP-43	activates	protein	0.50
LAMP1	activates	protein	0.50
Tdp-43	activates	pathway	0.50
LGALS3	activates	gene	0.50
STUB1	activates	gene	0.50
PARKINSON	activates	gene	0.50
amyotrophic lateral sclerosis	activates	gene	0.50
HUNTINGTON	activates	gene	0.50
Neurodegenerative Diseases	activates	disease	0.50
Spinal Cord	activates	cell_type	0.50
Chaperone	activates	pathway	0.50
disease	activates	disease	0.50
PPP3	activates	concept	0.50
Neuroblastoma	activates	disease	0.50
Autophagy	associated_with	process	0.50
Proteins	associated_with	protein	0.50
NDP52	activates	gene	0.50
CALCOCO2	activates	gene	0.50
CHIP	activates	protein	0.50
Infection	activates	disease	0.50
Proteins	activates	protein	0.50
ANXA1	activates	protein	0.50
microglia	activates	cell_type	0.50
NBR1	activates	gene	0.50
NF-κB	activates	concept	0.50
Autophagy	causes	process	0.50
UBIQUITIN	causes	protein	0.50
ULK1	activates	gene	0.50
TBK1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do different organelle-specific autophagy pathways coordinate during neurode

neurodegeneration | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SELECTIVE AUTOPHAGY

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

NRF2 Oxidative Stress Pathway

Mitochondrial Quality Control

Circadian Rhythm in Neurodegeneration

Autophagy Mechanisms

APOC4 — Apolipoprotein C-IV

nlrc5-protein

Mitochondrial Dysfunction in Neurodegeneration

LRRK2 Pathway in Parkinson's Disease

Neuronal Ceroid Lipofuscinosis (NCL)

Gene-Mechanism-Therapy Causal Chains

proteasome-ubiquitin-system-dysfunction-parkinsons

Neuroinflammation-Mitochondria Crosstalk Pathway

TYNDASE — Tyndall

mitophagy-defect

ATP13A2 Lysosomal Dysfunction Pathway in Parkinson's Disease

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

rapamycin-tauopathy

FOXO1 Protein