Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABAergic neurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Cell Type | GABAergic neurons |
| Definition | <table class="infobox infobox-cell"> |
| Key Markers | SST, BDNF, PVALB, APP, GABA, RNA, GABRA1, DRD2 |
| Key Pathways | unfolded protein response, synaptic plasticity, glutamate signaling |
| Associated Diseases | Alzheimer's disease, epilepsy, anxiety, neurodegeneration, neuroinflammation, autism |
| Linked Hypotheses | 31 hypotheses |
Knowledge base pages for this entity
graph TD
GABAergic_neurons["GABAergic neurons"] -->|"mediates"| Sleep_Restoration["Sleep Restoration"]
style Sleep_Restoration fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
GABAergic_neurons["GABAergic neurons"] -->|"protects against"| Alzheimer_s_Disease["Alzheimer's Disease"]
style Alzheimer_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
GABAergic_neurons["GABAergic neurons"] -->|"regulates"| neurodegeneration["neurodegeneration"]
style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Alzheimer_s_disease["Alzheimer's disease"] -->|"affects"| GABAergic_neurons["GABAergic neurons"]
style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
SST["SST"] -->|"associated"| GABAergic_neurons["GABAergic neurons"]
style SST fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
PVALB["PVALB"] -->|"associated"| GABAergic_neurons["GABAergic neurons"]
style PVALB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
epilepsy["epilepsy"] -->|"affects"| GABAergic_neurons["GABAergic neurons"]
style epilepsy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
anxiety["anxiety"] -->|"affects"| GABAergic_neurons["GABAergic neurons"]
style anxiety fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
style GABAergic_neurons fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Fragile X-associated tremor/ataxia syndrome | implicated_in | disease | 0.90 |
| neurodegeneration | regulates | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CGG repeat expansion | causes | compound | 0.85 |
| Alzheimer's disease | affects | disease | 0.80 |
| SST | associated_with | gene | 0.80 |
| PVALB | associated_with | gene | 0.80 |
| SST | expressed_in | gene | 0.80 |
| epilepsy | affects | disease | 0.70 |
| anxiety | affects | disease | 0.70 |
| GABA | expressed_in | gene | 0.70 |
| RNA | expressed_in | gene | 0.70 |
| BDNF | regulates | gene | 0.70 |
| PVALB | expressed_in | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| GABA | implicated_in | gene | 0.60 |
| GABA | biomarker_for | gene | 0.60 |
| PVALB | regulates | gene | 0.60 |
| neurodegeneration | affects | disease | 0.60 |
| PVALB | biomarker_for | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| neuroinflammation | affects | disease | 0.60 |
| unfolded protein response | active_in | pathway | 0.60 |
| autism | affects | disease | 0.60 |
| RNA | regulates | gene | 0.60 |
| RNA | implicated_in | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| depression | affects | disease | 0.60 |
| GABA | inhibits | gene | 0.60 |
| AMPK | regulates | gene | 0.60 |
| APP | expressed_in | gene | 0.60 |
| RORB | expressed_in | gene | 0.60 |
| LAMP5 | expressed_in | gene | 0.60 |
| GAD1 | expressed_in | gene | 0.60 |
| SLC6A2 | expressed_in | gene | 0.60 |
| CACNA1H | expressed_in | gene | 0.60 |
| GRIA1 | expressed_in | gene | 0.60 |
| GABRA1 | expressed_in | gene | 0.60 |
| DRD2 | expressed_in | gene | 0.60 |
| CACNA1B | expressed_in | gene | 0.60 |
| DRD1 | expressed_in | gene | 0.60 |
| HTR2A | expressed_in | gene | 0.60 |
| GRIK4 | expressed_in | gene | 0.60 |
| SLC1A1 | expressed_in | gene | 0.60 |
| GABRB2 | expressed_in | gene | 0.60 |
| HTR2C | expressed_in | gene | 0.60 |
| GRM5 | expressed_in | gene | 0.60 |
| GDNF | expressed_in | gene | 0.60 |
| AMPK | expressed_in | gene | 0.60 |
| GABA | transported_by | gene | 0.60 |
| axon | found_in | organelle | 0.60 |
| purinergic receptor | expressed_in | receptor | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||