gene 2,340 words KG: CTSB
Contents

CTSB Gene

🧬 Gene Info
Gene SymbolCTSB
Full NameCathepsin B
Chromosome8p23.1
Subcellular Localization| Compartment | Function |
Molecular Weight26 kDa
Amino Acids339 aa
Exons13
PathwaysAutophagy
UniProt IDP07846
NCBI Gene ID1508
Ensembl IDENSG00000164733
OMIM116810
GeneCardsCTSB
Human Protein AtlasCTSB
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, APOPTOSIS
Known Drugs/Compoundsrapamycin, tannic acid
InteractionsACTB, Actin, AGING, AIF1, AKT, ALS
SciDEX HypothesesSelective cathepsin B inhibition prevents cathepsi
KG Connections815 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (31)

Complement C1q Subtype Switching
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Cryptic Exon Silencing Restoration
Score: 0.53
← Prevpg 2/2

Related Analyses (12)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (9)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with
ACE Gene
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: activates
adam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CTSB activates C1QA
CTSB activates SPP1
CTSB activates GRN
STIP1 associated_with CTSB
LGALS3 associated_with CTSB
HSPA8 associated_with CTSB
MCOLN1 associated_with CTSB
SQSTM1 associated_with CTSB
SOD1 associated_with CTSB
BCL2 associated_with CTSB

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