concept

MOBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MOBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

68Connections

0Hypotheses

0Analyses

43Outgoing

25Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MOBP
Key Genes/Proteins	PSP, STX6, MAPT, GENES, ALZHEIMER, HSPA1A
Related Diseases	Parkinson's Disease Dementia, Alzheimer, Dementia, Parkinson, Als

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MOBP["MOBP"]
    MOBP -->|"upregulates"| Parkinson_s_Disease_Dementia["Parkinson's Disease Dementia"]
    MOBP -->|"activates"| Alzheimer["Alzheimer"]
    MOBP -->|"activates"| Dementia["Dementia"]
    MOBP -->|"activates"| Parkinson["Parkinson"]
    MOBP -->|"activates"| Als["Als"]
    MOBP -->|"activates"| ALS["ALS"]
    MOBP -->|"activates"| GENES["GENES"]
    MOBP -->|"activates"| ALZHEIMER["ALZHEIMER"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| MOBP
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"activates"| MOBP
    MSR1["MSR1"] -->|"activates"| MOBP
    AND["AND"] -->|"activates"| MOBP
    MICROGLIA["MICROGLIA"] -->|"activates"| MOBP
    PARKINSON["PARKINSON"] -->|"activates"| MOBP
    DEMENTIA["DEMENTIA"] -->|"activates"| MOBP
    GENES -->|"activates"| MOBP

Outgoing (43)

Target	Relation	Type	Str
Parkinson's Disease Dementia	upregulates	disease	0.80
PSP	regulates	gene	0.70
STX6	regulates	gene	0.70
Alzheimer	activates	disease	0.65
Dementia	activates	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
GENES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
HSPA1A	activates	gene	0.60
PLP1	activates	gene	0.60
MBP	activates	gene	0.60
DEMENTIA	activates	gene	0.60
MYELIN	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
Phagocytosis	activates	pathway	0.60
RNA	activates	gene	0.60
AND	activates	gene	0.60
MSR1	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
MICROGLIA	activates	gene	0.60
PARKINSON	activates	gene	0.60
Oligodendrocyte	activates	cell_type	0.60
Microglia	activates	cell_type	0.60
App	activates	protein	0.60
oligodendrocytes	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
frontotemporal dementia	expressed_in	disease	0.60
PSP	interacts_with	gene	0.60
frontotemporal dementia	interacts_with	disease	0.60
Parkinson's disease	interacts_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
frontotemporal dementia	implicated_in	disease	0.60
RUNX2	regulates	gene	0.60
PSP	causes	gene	0.60
RUNX2	causes	gene	0.60
STX6	causes	gene	0.60
Prefrontal Cortex	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Oligodendrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55

Incoming (25)

Source	Relation	Type	Str
MAPT	regulates	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
MSR1	activates	gene	0.60
AND	activates	gene	0.60
MICROGLIA	activates	gene	0.60
PARKINSON	activates	gene	0.60
DEMENTIA	activates	gene	0.60
GENES	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
MBP	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
HSPA1A	activates	gene	0.60
MYELIN	activates	gene	0.60
PLP1	activates	gene	0.60
APOE	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
MAPT	interacts_with	gene	0.60
APOE	implicated_in	gene	0.60
MAPT	implicated_in	gene	0.60
C4A	regulates	gene	0.60
C4A	causes	gene	0.60
APOE	regulates	gene	0.60
DUSP10	regulates	gene	0.60
EIF2AK3	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MOBP

Understanding Entity Pages

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Corticobasal Degeneration (CBD)

psp-tauopathy

CBS/PSP Genetic Architecture

Progressive Supranuclear Palsy

4R Tauopathy Mechanisms

Genetics of Progressive Supranuclear Palsy

Neuropathology of Progressive Supranuclear Palsy

Whole Genome Sequencing for CBS/PSP

Tauopathy

curepsp-genetics-program

Genetic Risk Factors Across 4R-Tauopathies

Cell-Type Vulnerability in 4R-Tauopathies

PSP-CBD Overlap Syndrome

CBS vs PSP: Comparative Mechanism Analysis

Genetics of 4R-Tauopathies: Cross-Disease Comparison

PSP Genetic Variants

John R. Hodges