RNA-Binding Competition Therapy for TDP-43 Cross-Seeding

graph TD
    A["TDP-43 / TARDBP"] --> B["RNA Processing Functions"]
    B --> C["Splicing Regulation"]
    B --> D["RNA Transport"]
    B --> E["RNA Stability"]

    F["Pathological Conditions"] --> G["Cytoplasmic Mislocalization"]
    G --> H["Hyperphosphorylation"]
    H --> I["TDP-43 Aggregation"]
    I --> J["Cross-Seeding with Other Proteins"]
    J --> K["ALS/FTD Pathology"]

    L["RNA-Binding Competition Therapy"] --> M["Designed RNA Decoys"]
    M --> N["Compete for TDP-43 RNA-Binding Domain"]
    N --> O["Sequester TDP-43 in Soluble Form"]

    O --> P["Prevent Cytoplasmic Aggregation"]
    O --> Q["Block Cross-Seeding"]
    O --> R["Preserve Some RNA Processing"]

    P --> S["Reduced TDP-43 Inclusions"]
    Q --> T["Prevented Prion-like Spread"]
    R --> U["Maintained Cellular Function"]

    S --> V["Neuroprotection in ALS/FTD"]
    T --> V
    U --> V

    style A fill:#264653,stroke:#ffd54f,color:#e0e0e0
    style F fill:#4a1942,stroke:#ce93d8,color:#e0e0e0
    style L fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
    style V fill:#2a3a1a,stroke:#c5e1a5,color:#e0e0e0