Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about synapse: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Gene Symbol | SYNAPSE |
| Associated Diseases | ALS, Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis |
| KG Connections | 1662 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
synapse["synapse"] -->|"found in"| microglia["microglia"]
style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
synapse["synapse"] -->|"involved in"| unfolded_protein_response["unfolded protein response"]
style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
synapse["synapse"] -->|"involved in"| complement_cascade["complement cascade"]
style complement_cascade fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
synapse["synapse"] -->|"enriched in"| hippocampus["hippocampus"]
style hippocampus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
synapse["synapse"] -->|"found in"| neural_stem_cells["neural stem cells"]
style neural_stem_cells fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
synapse["synapse"] -->|"found in"| neurons["neurons"]
style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
synapse["synapse"] -->|"involved in"| synaptic_plasticity["synaptic plasticity"]
style synaptic_plasticity fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
Alzheimer_s_disease["Alzheimer's disease"] -->|"disrupts"| synapse["synapse"]
style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
depression["depression"] -->|"disrupts"| synapse["synapse"]
style depression fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
neurodegeneration["neurodegeneration"] -->|"disrupts"| synapse["synapse"]
style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
neuroinflammation["neuroinflammation"] -->|"disrupts"| synapse["synapse"]
style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
epilepsy["epilepsy"] -->|"disrupts"| synapse["synapse"]
style epilepsy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
style synapse fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Source | Relation | Type | Str |
|---|---|---|---|
| C1q | tags | protein | 0.80 |
| C3 | tags | protein | 0.80 |
| Complement Receptors | recognizes | protein | 0.80 |
| microglia | protects_against | entity | 0.60 |
| mitochondria | loss_affects | entity | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from | 0.588 | neurodegeneration | How does APOE4's beneficial immune funct |
| SASP-Mediated Cholinergic Synapse Disruption | 0.564 | neurodegeneration | Senolytic therapy for age-related neurod |
| TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina | 0.520 | neurodegeneration | How do the seven novel ALS genes functio |
| Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto | 0.454 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455
neuro-oncology | 2026-04-13 | 0 hypotheses
synaptic biology | 2026-04-07 | 0 hypotheses
synaptic biology | 2026-04-07 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Clinical, Immunological, and Vesicular Markers in Sarcopenia and Presarcopenia. [PMID:40917056] | Shuliko LM, Svarovsky DA, Spirina LV, Og | Front Biosci (Landmark Ed) | 2025 | 1 |
| CD47-blocking antibody interferes with neutrophil extracellular traps formation [PMID:39951937] | Diao Y, Hao M, Xie M, Hu X, Tan R, Wang | J Neuroimmunol | 2025 | 1 |
| Asparagine Endopeptidase Inhibition Attenuates Tissue Plasminogen Activator-Indu [PMID:40116141] | Xie G, Jiang G, Huang L, Sun S, Li X, Wu | CNS Neurosci Ther | 2025 | 1 |
| Enhanced anticancer activity of nanoemulsified cardamom extract via modulation o [PMID:41658858] | ["Soltani T", "Karimian M", "Vaziri H", | Biochemistry and biophysics re | 2026 | 0 |
| Integrated transcriptomic, proteomic, and metabolomic analyses reveal molecular [PMID:41850064] | ["Wang H", "Liu Y", "Jiang K", "Yin J", | Poultry science | 2026 | 0 |
| Fragment merging design, synthesis, and biological evaluation of novel methyl Se [PMID:41785527] | ["Shaaban S", "Hawas S", "Elmaaty A", "B | Bioorganic & medicinal chemist | 2026 | 0 |
| Theranekron modulates extracellular matrix and apoptotic signaling pathways in c [PMID:41852375] | ["Kuccukturk S", "Duran T", "Vanli S", " | Cytotechnology | 2026 | 0 |
| Saliva liquid biopsy: MMP2, MMP9, and TIMP2 as potential diagnostic biomarkers i [PMID:41779471] | ["Cruz-Romero S", "Baldi\u00f3n A", "Taw | Journal of applied oral scienc | 2026 | 0 |
| Glomerular Transcriptome Analysis Reveals Endothelial Disturbances in Patients W [PMID:41659822] | ["Nelson-Taylor S", "Troost J", "Giannin | Kidney medicine | 2026 | 0 |
| Encapsulation of hydroxyurea in exosomes derived from adipose mesenchymal stem c [PMID:41702234] | ["Taheri Kangarshahi Z", "Ganji S", "Ash | Translational oncology | 2026 | 0 |
| NSUN2 promoted tumor growth and metastatic via m [PMID:41794778] | ["Li R", "Jin D", "Shao S", "Guo J"] | Cell death & disease | 2026 | 0 |
| Membrane-Type 5 Matrix Metalloproteinase (MT5-MMP): Background and Proposed Role [PMID:40867559] | ["Jadhav D", "Knapinska A", "Wang H", "F | Biomolecules | 2025 | 0 |
| Pyridostigmine Treatment Significantly Alleviates Isoprenaline-Induced Chronic H [PMID:40725139] | Marinković ST, Sobot T, Maksimović ŽM, Ð | International journal of molec | 2025 | 0 |
| Effects of Mono- (2-ethylhexyl) phthalate and Phthalic Acid Monobenzyl Ester on [PMID:40769497] | ["Wu Q", "Sun Y", "Liu Q", "Zhao X", "Li | Reproductive toxicology (Elmsf | 2025 | 0 |
| Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer [PMID:39858430] | ["Shoari A", "Ashja Ardalan A", "Dimesa | Biomolecules | 2024 | 0 |
| Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence [PMID:39538054] | ["Deng X", "Zhang Y", "He X", "Li L", "Y | Journal of bioenergetics and b | 2024 | 0 |
| Biological significance and pathophysiological role of Matrix Metalloproteinases [PMID:39322129] | ["Ganguly K", "Adhikary K", "Acharjee A" | International journal of biolo | 2024 | 0 |
| Reduced inhibitory and excitatory input onto parvalbumin interneurons mediated b [PMID:36543316] | ["Zhang L", "Gao Y", "Zhao C", "Xia J", | Neuropharmacology | 2023 | 0 |
| Unlocking the potential of iridium and ruthenium arene complexes as anti-tumor a [PMID:36370504] | Lv M, Qian X, Li S, Gong J, Wang Q, Qian | Journal of inorganic biochemis | 2023 | 0 |
| Low protein-induced intrauterine growth restriction as a risk factor for schizop [PMID:36720849] | ["Allg\u00e4uer L", "Cabungcal J", "Yzyd | Translational psychiatry | 2023 | 0 |