concept

CD2AP DEFICIENCY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD2AP DEFICIENCY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

38Outgoing

25Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CD2AP DEFICIENCY
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, APP, APP/PS1
Related Diseases	ALS, Alzheimer
Related Pathways	Amyloid, Apoptosis, Complement

Pathway Diagram

graph TD
    CD2AP_DEFICIENCY["CD2AP DEFICIENCY"]
    CD2AP_DEFICIENCY -.protects against.-> Cognitive_Deficits["Cognitive Deficits"]
    CD2AP_DEFICIENCY -->|"activates"| p38_MAPK["p38 MAPK"]
    CD2AP_DEFICIENCY -->|"activates"| neuronal_apoptosis["neuronal apoptosis"]
    CD2AP_DEFICIENCY -->|"activates"| Alzheimer["Alzheimer"]
    CD2AP_DEFICIENCY -->|"activates"| Ms["Ms"]
    CD2AP_DEFICIENCY -->|"activates"| Apoptosis["Apoptosis"]
    CD2AP_DEFICIENCY -->|"target for"| Mapk["Mapk"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| CD2AP_DEFICIENCY
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CD2AP_DEFICIENCY
    AND["AND"] -->|"target for"| CD2AP_DEFICIENCY
    APP_PS1["APP/PS1"] -->|"activates"| CD2AP_DEFICIENCY
    APP["APP"] -->|"activates"| CD2AP_DEFICIENCY
    TAU["TAU"] -->|"activates"| CD2AP_DEFICIENCY
    CD2AP["CD2AP"] -->|"target for"| CD2AP_DEFICIENCY
    MAPK["MAPK"] -->|"target for"| CD2AP_DEFICIENCY

Outgoing (38)

Target	Relation	Type	Str
Cognitive Deficits	protects_against	phenotype	0.87
neuronal apoptosis	activates	process	0.70
p38 MAPK	activates	pathway	0.70
Ms	activates	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	protects_against	disease	0.65
Alzheimer	activates	disease	0.65
Apoptosis	activates	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
CD2AP	protects_against	gene	0.60
COMPLEMENT	associated_with	gene	0.60
GENES	regulates	gene	0.60
RNA	associated_with	gene	0.60
MICROGLIA	protects_against	gene	0.60
Phagocytosis	associated_with	pathway	0.60
Amyloid	protects_against	pathway	0.60
Complement	associated_with	pathway	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
P38	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	therapeutic_target	gene	0.60
NEURON	activates	gene	0.60
CD2AP	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
TAU	activates	gene	0.60
APP	activates	gene	0.60
APP/PS1	activates	gene	0.60
Tau Phosphorylation	activates	pathway	0.60
MAPK	activates	gene	0.60
AND	activates	gene	0.60
P38	activates	gene	0.60
Mapk	activates	pathway	0.60
TAU PATHOLOGY	activates	gene	0.60
Endothelial Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55

Incoming (25)

Source	Relation	Type	Str
CD2AP	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	therapeutic_target	gene	0.60
APP/PS1	activates	gene	0.60
APP	activates	gene	0.60
TAU	activates	gene	0.60
CD2AP	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
P38	therapeutic_target	gene	0.60
NEURON	activates	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
MICROGLIA	protects_against	gene	0.60
CD2AP GENE	associated_with	gene	0.60
SYNAPSE	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
GENES	regulates	gene	0.60
PHAGOCYTOSIS	associated_with	gene	0.60
CD2AP	protects_against	gene	0.60
COMPLEMENT	associated_with	gene	0.60
ALZHEIMER	protects_against	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
CSF1R	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity