FAM134B

Understanding Entity Pages

This page aggregates everything SciDEX knows about FAM134B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

FAM134B is an ER-phagy receptor associated with HSAN2 and Parkinson's disease

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flowchart TD
    FAM134B["FAM134B<br/>ER-phagy Receptor"]
    
    %% ER Stress and Autophagy Pathway
    ER_Stress["ER Stress<br/>Response"]
    EIF2AK3["EIF2AK3<br/>(PERK)"]
    EIF2S1["EIF2S1<br/>(eIF2alpha)"]
    CHOP["CHOP<br/>Pro-apoptotic Factor"]
    
    %% Autophagy Components
    LC3["LC3<br/>Autophagosome Marker"]
    ER_Phagy["ER-phagy<br/>Process"]
    
    %% Mitochondrial Quality Control
    PRKN["PRKN<br/>(Parkin)"]
    MUL1["MUL1<br/>Mitochondrial Ligase"]
    MIRO1["MIRO1<br/>Mitochondrial Transport"]
    DRP1["DRP1<br/>Mitochondrial Fission"]
    
    %% Cell Death Pathways
    BCL2L11["BCL2L11<br/>(BIM)"]
    BNIP3["BNIP3<br/>Mitochondrial Death"]
    RIPK3["RIPK3<br/>Necroptosis"]
    
    %% Neurodegeneration Outcomes
    ALS["Amyotrophic Lateral<br/>Sclerosis"]
    Alzheimer["Alzheimer's<br/>Disease"]
    Parkinson["Parkinson's<br/>Disease"]
    FTD["Frontotemporal<br/>Dementia"]
    
    %% Key Interactions
    FAM134B --|"regulates"|--> ER_Phagy
    FAM134B --|"binds"|--> LC3
    ER_Stress --|"activates"|--> EIF2AK3
    EIF2AK3 --|"phosphorylates"|--> EIF2S1
    EIF2S1 --|"induces"|--> CHOP
    
    FAM134B --|"interacts"|--> PRKN
    FAM134B --|"interacts"|--> MUL1
    PRKN --|"ubiquitinates"|--> MIRO1
    MUL1 --|"regulates"|--> DRP1
    
    CHOP --|"activates"|--> BCL2L11
    BCL2L11 --|"promotes"|--> BNIP3
    RIPK3 --|"triggers"|--> Cell_Death["Cell Death<br/>Pathways"]
    
    ER_Phagy --|"dysfunction"|--> ALS
    ER_Phagy --|"dysfunction"|--> Alzheimer
    PRKN --|"mutations"|--> Parkinson
    Cell_Death --|"leads to"|--> FTD
    
    %% Styling
    style FAM134B fill:#006494
    style ER_Phagy fill:#1b5e20
    style LC3 fill:#1b5e20
    style PRKN fill:#4a1a6b
    style MUL1 fill:#4a1a6b
    style CHOP fill:#ef5350
    style BCL2L11 fill:#ef5350
    style BNIP3 fill:#ef5350
    style RIPK3 fill:#ef5350
    style ALS fill:#5d4400
    style Alzheimer fill:#5d4400
    style Parkinson fill:#5d4400
    style FTD fill:#5d4400