Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CTS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CTS |
| Aliases | Page for CTS Gene |
| Chromosome | 1q21.3 |
| Protein Family | Papain family cysteine proteases |
| Protein Type | Enzyme |
| Function | Cathepsins and their role in immune system homeostasis. |
| Primary Expression | professional antigen-presenting cells (macrophages, dendritic cells, B cells) |
| Molecular Weight | 24 kDa |
| Amino Acids | 331 aa |
| Pathways | Immune Response |
| UniProt ID | P25774 |
| NCBI Gene ID | 1520 |
| Ensembl ID | ENSG00000163131 |
| OMIM | 600845 |
| GeneCards | CTS |
| Human Protein Atlas | CTS |
| Associated Diseases | neurodegeneration |
| Interactions | CD8 |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CTS"]
N1["Neuropathy"]
N0 -->|"expressed in"| N1
N2["Ms"]
N0 -->|"expressed in"| N2
N3["OVERVIEW"]
N0 -->|"expressed in"| N3
N4["JAK2"]
N0 -->|"regulates"| N4
N5["SPR"]
N0 -->|"associated with"| N5
N6["CD8"]
N0 -->|"inhibits"| N6
N7["Immune Response"]
N0 -->|"regulates"| N7
N8["STAT3"]
N8 -->|"regulates"| N0
N9["neurodegeneration"]
N0 -->|"implicated in"| N9
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 pathway
class N8 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Neuropathy | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| SPR | associated_with | gene | 0.60 |
| CD8 | inhibits | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| GAPDH | regulates | gene | 0.60 |
| GATA3 | regulates | gene | 0.60 |
| GLB1 | regulates | gene | 0.60 |
| IL1RL1 | regulates | gene | 0.60 |
| IL4 | regulates | gene | 0.60 |
| IL7R | regulates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| LDH | regulates | gene | 0.60 |
| PECAM1 | regulates | gene | 0.60 |
| RORC | regulates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| VIM | regulates | gene | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| RNA | associated_with | gene | 0.60 |
| MAP1LC3 | regulates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| OVERVIEW | expressed_in | gene | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| JAK2 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Mobile App-Based Intervention for BPSD in Community-Dwelling Dementia | clinical | dementia with behavioral and p | 0.950 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT1 and SIRT6: The role in aging-related diseases. [PMID:37499928] | You Y, Liang W | Biochim Biophys Acta Mol Basis | 2023 | 0 |
| SIRT1 and SIRT6: The role in aging-related diseases. [PMID:37499928] | You Y, Liang W | Biochimica et biophysica acta. | 2023 | 0 |
| Regulation of SIRT1 and Its Roles in Inflammation. [PMID:35359990] | Yang Y, Liu Y, Wang Y, Chao Y, Zhang J, | Frontiers in immunology | 2022 | 0 |
| SIRT1 and aging related signaling pathways. [PMID:32084459] | Chen C, Zhou M, Ge Y, Wang X | Mechanisms of ageing and devel | 2020 | 0 |
| NAD(+) metabolism governs the proinflammatory senescence-associated secretome. [PMID:30778219] | Unknown | Nat Cell Biol | 2019 | 0 |
| Sirt1 and the Mitochondria. [PMID:26831453] | Tang BL | Molecules and cells | 2016 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CTS in their description or question text
Score: 0.770 · neurodegeneration · 2026-04-22
## Mechanistic Overview H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from Epigenomic Homeostasis starts from th
Score: 0.750 · neurodegeneration · 2026-04-22
**Molecular Mechanism and Rationale** The VHH-Fc fusion construct leveraging separate blood-brain barrier (BBB) targeti
Score: 0.745 · unknown disease · 2026-04-26
Soluble PDGFRβ (sPDGFRβ) is released into the bloodstream upon pericyte damage, serving as a peripheral indicator of blo
Score: 0.730 · neurodegeneration · 2026-04-25
AD-risk trafficking defects in SORL1/BIN1/PICALM/retromer may generate parallel early outputs: amyloidogenic APP sorting
Score: 0.730 · neurodegeneration · 2026-04-26
G2019S specifically hyperactivates LRRK2 when recruited to swelling lysosomes via RAB29, creating pathogenic positive fe
Score: 0.685 · unknown disease · 2026-04-26
Aquaporin-4 (AQP4) is normally highly polarized to astrocyte end-feet surrounding blood vessels, critical for glymphatic
Score: 0.685 · unknown disease · 2026-04-26
Plasma fibrinogen leaks across the compromised BBB and undergoes coagulation cascade activation and cross-linking by fac
Score: 0.676 · alzheimers · 2026-04-28
Alzheimer's pathology disrupts circadian PER1/2 and BMAL1 rhythms in hippocampal neurons. Gamma entrainment, particularl
Score: 0.636 · neurodegeneration · 2026-04-16
## Mechanistic Overview TREM2-Dependent Microglial Phagocytosis Acts as a Strain Selection Filter starts from the claim
Score: 0.630 · neurodegeneration · 2026-04-22
## Mechanistic Overview Intestinal Permeability Defects → Systemic LPS Translocation → Microglial Priming starts from th
Score: 0.630 · neurodegeneration · 2026-04-22
## **Molecular Mechanism and Rationale** The autophagosome-lysosome fusion process represents a critical checkpoint in
Score: 0.626 · neurodegeneration · 2026-04-28
mutant FUS effects split between motor-neuron intrinsic stress and glial/NMJ inflammatory signaling should produce a mea
Score: 0.625 · unknown disease · 2026-04-26
No single biomarker fully captures the heterogeneity of early BBB dysfunction across neurodegeneration subtypes. A compo
Score: 0.625 · unknown disease · 2026-04-26
Soluble PDGFRβ (sPDGFRβ) is released into the bloodstream upon pericyte damage, serving as a peripheral indicator of blo