Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CTS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CTSS |
| Full Name | Cathepsin S |
| Chromosome | 1q21.3 |
| Protein Family | Papain family cysteine proteases |
| Protein Type | Protease |
| Function | encodes a lysosomal cysteine protease that has emerged as a critical player in both immune function and neurodegenerative disease pathogenesis. |
| Primary Expression | Microglia, Macrophages, Dendritic cells |
| Molecular Weight | 37 kDa |
| Amino Acids | 331 aa |
| UniProt ID | P25774 |
| NCBI Gene ID | 1520 |
| Ensembl ID | ENSG00000163131 |
| OMIM | 600565 |
| GeneCards | CTSS |
| Human Protein Atlas | CTSS |
| Associated Diseases | Aging |
| Interactions | AHR, CTSD, LAMP2, JAK2, STAT3, APP |
| KG Connections | 60 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CTS"]
N1["Neuropathy"]
N0 -->|"expressed in"| N1
N2["Ms"]
N0 -->|"expressed in"| N2
N3["OVERVIEW"]
N0 -->|"expressed in"| N3
N4["JAK2"]
N0 -->|"regulates"| N4
N5["SPR"]
N0 -->|"associated with"| N5
N6["CD8"]
N0 -->|"inhibits"| N6
N7["Immune Response"]
N0 -->|"regulates"| N7
N8["STAT3"]
N8 -->|"regulates"| N0
N9["neurodegeneration"]
N0 -->|"implicated in"| N9
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 pathway
class N8 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Neuropathy | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| OVERVIEW | expressed_in | gene | 0.60 |
| JAK2 | regulates | gene | 0.60 |
| SPR | associated_with | gene | 0.60 |
| CD8 | inhibits | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| GAPDH | regulates | gene | 0.60 |
| GATA3 | regulates | gene | 0.60 |
| GLB1 | regulates | gene | 0.60 |
| IL1RL1 | regulates | gene | 0.60 |
| IL4 | regulates | gene | 0.60 |
| IL7R | regulates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| LDH | regulates | gene | 0.60 |
| PECAM1 | regulates | gene | 0.60 |
| RORC | regulates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| VIM | regulates | gene | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| RNA | associated_with | gene | 0.60 |
| MAP1LC3 | regulates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-Dependent Microglial Phagocytosis Acts as a Strain Sel | 0.636 | neurodegeneration | What are the specific molecular determin |
| MITF Acts as the Primary Transcriptional Effector Downstream | 0.444 | neurodegeneration | How does HDAC1/2 deletion specifically e |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.596
epigenetics | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.505
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||