gene

CTS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections
2Hypotheses
25Analyses
26Outgoing
7Incoming

Summary

Page for CTS Gene - Cathepsin S

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🧬 Gene Info
Gene SymbolCTSS
Full NameCathepsin S
Chromosome1q21.3
Protein FamilyPapain family cysteine proteases
Protein TypeProtease
Functionencodes a lysosomal cysteine protease that has emerged as a critical player in both immune function and neurodegenerative disease pathogenesis.
Primary ExpressionMicroglia, Macrophages, Dendritic cells
Molecular Weight37 kDa
Amino Acids331 aa
UniProt IDP25774
NCBI Gene ID1520
Ensembl IDENSG00000163131
OMIM600565
GeneCardsCTSS
Human Protein AtlasCTSS
Associated DiseasesAging
InteractionsAHR, CTSD, LAMP2, JAK2, STAT3, APP
KG Connections60 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CTS — AlphaFold P25774 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CTS Gene - Cathepsin S

gene · 3037 words

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

primary-progressive-aphasia

disease · 7088 words

Device Therapies Comparison for CBS/PSP

therapeutic · 6867 words

PI-2620 Tau PET in PSP

clinical · 5625 words

Pathway Diagram

flowchart TD
    N0["CTS"]
    N1["Neuropathy"]
    N0 -->|"expressed in"| N1
    N2["Ms"]
    N0 -->|"expressed in"| N2
    N3["OVERVIEW"]
    N0 -->|"expressed in"| N3
    N4["JAK2"]
    N0 -->|"regulates"| N4
    N5["SPR"]
    N0 -->|"associated with"| N5
    N6["CD8"]
    N0 -->|"inhibits"| N6
    N7["Immune Response"]
    N0 -->|"regulates"| N7
    N8["STAT3"]
    N8 -->|"regulates"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 pathway
    class N8 gene

Outgoing (26)

TargetRelationTypeStr
Neuropathyexpressed_indisease0.65
Msexpressed_indisease0.65
OVERVIEWexpressed_ingene0.60
JAK2regulatesgene0.60
SPRassociated_withgene0.60

Incoming (7)

SourceRelationTypeStr
STAT3regulatesgene0.60
APOEassociated_withgene0.60
ACTBregulatesgene0.60
BECN1regulatesgene0.60
CD31regulatesgene0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
TREM2-Dependent Microglial Phagocytosis Acts as a Strain Sel 0.636 neurodegeneration What are the specific molecular determin
MITF Acts as the Primary Transcriptional Effector Downstream 0.444 neurodegeneration How does HDAC1/2 deletion specifically e

Mentioning Analyses (25)

Scientific analyses that reference this entity

How do sphingomyelin/ceramide ratios specifically regulate BACE1 clustering and

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.596

Are age-related static epigenetic patterns pathogenic or protective compensatory

epigenetics | 2026-04-15 | 0 hypotheses

What are the physiological functions of BACE1 beyond APP processing that could c

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527

Why does autophagy inhibition improve neuronal survival when autophagy is typica

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.505

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found