GLB1

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GLB1 encodes beta-galactosidase, a lysosomal hydrolase. Deficiency causes GM1 gangliosidosis and Morquio B disease - lysosomal storage disorders with neurological manifestations.

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graph TD
    GLB1["GLB1 (beta-galactosidase)"]
    
    %% Senescence and aging
    Senescence["Cellular Senescence"]
    CDKN1A["CDKN1A (p21)"]
    CDKN2A["CDKN2A (p16)"]
    ROS["Reactive Oxygen Species"]
    
    %% Mitophagy pathway
    Mitophagy["Mitophagy"]
    OPTINEURIN["OPTINEURIN"]
    NDP52["NDP52 (CALCOCO2)"]
    LC3["LC3 (MAP1LC3)"]
    UBIQUITIN["Ubiquitin"]
    
    %% Growth signaling
    MTOR["mTOR Signaling"]
    AKT["AKT Pathway"]
    PTEN["PTEN"]
    
    %% Disease associations
    Alzheimer["Alzheimer Disease"]
    TNF["TNF-alpha Inflammation"]
    
    %% Connections
    GLB1 -->|"accumulates in"| Senescence
    GLB1 -->|"activates"| Mitophagy
    
    Senescence -->|"upregulates"| CDKN1A
    Senescence -->|"upregulates"| CDKN2A
    ROS -->|"promotes"| Senescence
    
    GLB1 -->|"regulates"| OPTINEURIN
    OPTINEURIN -->|"recruits"| NDP52
    NDP52 -->|"binds"| LC3
    UBIQUITIN -->|"tags organelles"| Mitophagy
    
    PTEN -->|"inhibits"| AKT
    AKT -->|"activates"| MTOR
    MTOR -->|"suppresses"| Mitophagy
    
    GLB1 -->|"associated with"| Alzheimer
    TNF -->|"promotes"| Senescence
    
    %% Styling
    style GLB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Mitophagy fill:#1b5e20,stroke:#2e7d32,stroke-width:2px
    style OPTINEURIN fill:#1b5e20,stroke:#2e7d32,stroke-width:2px
    style PTEN fill:#4a1a6b,stroke:#7b1fa2,stroke-width:2px
    style Senescence fill:#ef5350,stroke:#d32f2f,stroke-width:2px
    style Alzheimer fill:#7d4200,stroke:#ef6c00,stroke-width:2px
    style ROS fill:#ef5350,stroke:#d32f2f,stroke-width:2px
    style MTOR fill:#4a1a6b,stroke:#7b1fa2,stroke-width:2px
    style AKT fill:#4a1a6b,stroke:#7b1fa2,stroke-width:2px