concept

ANXA5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANXA5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

0Hypotheses

0Analyses

50Outgoing

11Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ANXA5
Key Genes/Proteins	NOS3, ALZHEIMER, PIK3R1, HRAS, MMP9
Related Diseases	Cardiac Hypertrophy, Hypertensive Myocardial Hypertrophy, Als, Neurodegeneration, Alzheimer
Related Pathways	PI3K/AKT/Bcl-2 Pathway, MAPK signaling

Pathway Diagram

graph TD
    ANXA5["ANXA5"]
    ANXA5 -->|"inhibits"| Cardiomyocyte_Apoptosis["Cardiomyocyte Apoptosis"]
    ANXA5 -->|"causes"| Cardiac_Hypertrophy["Cardiac Hypertrophy"]
    ANXA5 -->|"inhibits"| PI3K_AKT_Bcl_2_Pathway["PI3K/AKT/Bcl-2 Pathway"]
    ANXA5 -.biomarker for.-> Hypertensive_Myocardial_Hypert["Hypertensive Myocardial Hypertrophy"]
    ANXA5 -->|"component_of"| ARPS["ARPS"]
    ANXA5 -->|"interacts"| Intracellular_Calcium_Ion_Leve["Intracellular Calcium Ion Level"]
    ANXA5 -->|"target for"| Als["Als"]
    ANXA5 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    RHOA["RHOA"] -->|"target for"| ANXA5
    PI3K["PI3K"] -->|"target for"| ANXA5
    SRC["SRC"] -->|"target for"| ANXA5
    IGF1["IGF1"] -->|"target for"| ANXA5
    ESR1["ESR1"] -->|"target for"| ANXA5
    APOPTOSIS["APOPTOSIS"] -->|"inhibits"| ANXA5
    AKT["AKT"] -->|"inhibits"| ANXA5

Outgoing (96)

Target	Relation	Type	Str
Cardiomyocyte Apoptosis	inhibits	process	0.95
Cardiac Hypertrophy	causes	phenotype	0.90
PI3K/AKT/Bcl-2 Pathway	inhibits	pathway	0.90
Hypertensive Myocardial Hypertrophy	biomarker_for	disease	0.88
ARPS	component_of	entity	0.80
Intracellular Calcium Ion Level	interacts_with	compound	0.78
MAPK signaling	participates_in	pathway	0.70
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
NOS3	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
HRAS	therapeutic_target	gene	0.60
MMP9	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
NEURON	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
MAPK14	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
Pi3K	therapeutic_target	pathway	0.60
Akt	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Cardiac hypertrophy	implicated_in	disease	0.60
APOPTOSIS	inhibits	gene	0.60
Pi3K/Akt	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
AKT	inhibits	gene	0.60
BAX	activates	gene	0.60
AND	inhibits	gene	0.60
BCL-2	activates	gene	0.60
PI3K	inhibits	gene	0.60
Cardiomyocyte	inhibits	cell_type	0.60
apoptosis pathway	participates_in	pathway	0.60
PI3K	activates	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
ESR1	regulates	gene	0.60
HRAS	regulates	gene	0.60
IGF1	regulates	gene	0.60
MAPK	regulates	gene	0.60
MAPK14	regulates	gene	0.60
MMP9	regulates	gene	0.60
NOS3	regulates	gene	0.60
PI3K	regulates	gene	0.60
PIK3R1	regulates	gene	0.60

Incoming (11)

Source	Relation	Type	Str
RHOA	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
IGF1	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
APOPTOSIS	inhibits	gene	0.60
AKT	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
BAX	activates	gene	0.60
AKT	activates	gene	0.60
ACTB	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found