Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL7R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | IL7R |
| Full Name | Interleukin-7 Receptor Alpha Chain |
| Aliases | Page for IL7R Gene |
| Chromosome | 5p13.2 |
| Function | The IL-7 receptor plays critical roles in immune system development and function |
| Primary Expression | T cells, B cells, brain (neurons, microglia) |
| Amino Acids | 439 aa |
| Exons | 8 |
| UniProt ID | P16871 |
| NCBI Gene ID | 3575 |
| Ensembl ID | ENSG00000168685 |
| OMIM | 146661 |
| GeneCards | IL7R |
| Human Protein Atlas | IL7R |
| Associated Diseases | Fibrosis, Inflammation, Ms |
| Interactions | TXNIP, HSPA1A, CXCR4, CSF1R, ETV6, ZFP36 |
| KG Connections | 119 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
IL7R["<b>IL7R</b>"]
Leukemia{"Leukemia"}
IL7R -->|"activates"| Leukemia
Als{"Als"}
IL7R -->|"activates"| Als
Fibrosis{"Fibrosis"}
IL7R -->|"associated with"| Fibrosis
Ms{"Ms"}
IL7R -->|"associated with"| Ms
Inflammation{"Inflammation"}
IL7R -->|"associated with"| Inflammation
Senescence{"Senescence"}
IL7R -->|"therapeutic target"| Senescence
Aging{"Aging"}
IL7R -->|"therapeutic target"| Aging
IL7R -->|"therapeutic target"| Ms
Autoimmune{"Autoimmune"}
IL7R -->|"therapeutic target"| Autoimmune
Lymphoma{"Lymphoma"}
IL7R -->|"biomarker for"| Lymphoma
IL7R -->|"biomarker for"| Als
Tumor{"Tumor"}
IL7R -->|"inhibits"| Tumor
TYK2["TYK2"]
TYK2 -->|"contributes to"| IL7R
PTK2B["PTK2B"]
PTK2B -->|"contributes to"| IL7R
ABL2["ABL2"]
ABL2 -->|"contributes to"| IL7R
NTRK3["NTRK3"]
NTRK3 -->|"contributes to"| IL7R
ETV6["ETV6"]
ETV6 -->|"activates"| IL7R
ABL1["ABL1"]
ABL1 -->|"contributes to"| IL7R
PDGFRB["PDGFRB"]
PDGFRB -->|"contributes to"| IL7R
GENES["GENES"]
GENES -->|"activates"| IL7R
JAK2["JAK2"]
JAK2 -->|"contributes to"| IL7R
EPOR["EPOR"]
EPOR -->|"contributes to"| IL7R
CSF1R["CSF1R"]
CSF1R -->|"contributes to"| IL7R
CXCL8["CXCL8"]
CXCL8 -->|"associated with"| IL7R
style IL7R fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Leukemia | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Fibrosis | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Senescence | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Autoimmune | therapeutic_target | disease | 0.65 |
| Lymphoma | biomarker_for | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| JAK2 | contributes_to | gene | 0.60 |
| PDGFRB | contributes_to | gene | 0.60 |
| NTRK3 | contributes_to | gene | 0.60 |
| CSF1R | contributes_to | gene | 0.60 |
| CCL5 | associated_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| CXCL10 | associated_with | gene | 0.60 |
| TXNIP | inhibits | gene | 0.60 |
| HSPA1A | inhibits | gene | 0.60 |
| CXCR4 | inhibits | gene | 0.60 |
| PTK2B | contributes_to | gene | 0.60 |
| JAK2 | activates | entity | 0.60 |
| NTRK3 | activates | entity | 0.60 |
| PDGFRB | activates | entity | 0.60 |
| PTK2B | activates | entity | 0.60 |
| TYK2 | activates | entity | 0.60 |
| TYK2 | contributes_to | gene | 0.60 |
| Rb | contributes_to | protein | 0.60 |
| PDGFRB | associated_with | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| LDH | regulates | gene | 0.60 |
| PECAM1 | regulates | gene | 0.60 |
| RORC | regulates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| VIM | regulates | gene | 0.60 |
| ETV6 | activates | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| IMMUNE INFILTRATION | associated_with | gene | 0.60 |
| Toll-Like Receptor | associated_with | pathway | 0.60 |
| Akt | associated_with | pathway | 0.60 |
| Pi3K | associated_with | pathway | 0.60 |
| IMMUNE INFILTRATION | therapeutic_target | gene | 0.60 |
| IL-6 | associated_with | gene | 0.60 |
| Immune Response | associated_with | pathway | 0.60 |
| ZFP36 | inhibits | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TYK2 | contributes_to | gene | 0.60 |
| PTK2B | contributes_to | gene | 0.60 |
| NTRK3 | contributes_to | gene | 0.60 |
| PDGFRB | contributes_to | gene | 0.60 |
| JAK2 | contributes_to | gene | 0.60 |
| CSF1R | contributes_to | gene | 0.60 |
| CXCL8 | associated_with | gene | 0.60 |
| CCL4 | associated_with | gene | 0.60 |
| IL7 | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| IL18 | associated_with | gene | 0.60 |
| DOCK2 | therapeutic_target | gene | 0.60 |
| CDK1 | associated_with | gene | 0.60 |
| PTGS2 | associated_with | gene | 0.60 |
| TXNIP | inhibits | gene | 0.60 |
| CSF1R | activates | entity | 0.60 |
| CSF1R | associated_with | gene | 0.60 |
| ACTB | regulates | gene | 0.60 |
| BECN1 | regulates | gene | 0.60 |
| CD31 | regulates | gene | 0.60 |
| CKB | regulates | gene | 0.60 |
| CTS | regulates | gene | 0.60 |
| GAPDH | regulates | gene | 0.60 |
| GATA3 | regulates | gene | 0.60 |
| GLB1 | regulates | gene | 0.60 |
| IL1RL1 | regulates | gene | 0.60 |
| IL4 | regulates | gene | 0.60 |
| ABL2 | contributes_to | gene | 0.60 |
| ETV6 | activates | gene | 0.60 |
| ABL1 | contributes_to | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| EPOR | contributes_to | gene | 0.60 |
| AGING | therapeutic_target | gene | 0.60 |
| TSLP | contributes_to | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| CRLF2 | contributes_to | gene | 0.60 |
| FLT3 | contributes_to | gene | 0.60 |
| ABL1 | activates | gene | 0.60 |
| ABL2 | activates | gene | 0.60 |
| CRLF2 | activates | gene | 0.60 |
| EPOR | activates | gene | 0.60 |
| FLT3 | activates | gene | 0.60 |
| ANXA5 | regulates | gene | 0.60 |
| PDGFRB | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||