gene

IL7R

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL7R: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections
0Hypotheses
0Analyses
50Outgoing
44Incoming

Summary

Page for IL7R Gene - Interleukin-7 Receptor Alpha Chain

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🧬 Gene Info
Gene SymbolIL7R
Full NameInterleukin-7 Receptor Alpha Chain
AliasesPage for IL7R Gene
Chromosome5p13.2
FunctionThe IL-7 receptor plays critical roles in immune system development and function
Primary ExpressionT cells, B cells, brain (neurons, microglia)
Amino Acids439 aa
Exons8
UniProt IDP16871
NCBI Gene ID3575
Ensembl IDENSG00000168685
OMIM146661
GeneCardsIL7R
Human Protein AtlasIL7R
Associated DiseasesFibrosis, Inflammation, Ms
InteractionsTXNIP, HSPA1A, CXCR4, CSF1R, ETV6, ZFP36
KG Connections119 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: IL7R — AlphaFold P16871 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

IL7R Gene - Interleukin-7 Receptor Alpha Chain

gene · 754 words

IL1RL1 Gene

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Multiple Sclerosis Mechanistic Pathway

mechanism · 1877 words

JAK3 Gene

gene · 1443 words

TSLP Signaling in Neuroinflammation

mechanism · 973 words

NTRK3 Gene

gene · 930 words

Pathway Diagram

graph TD
    IL7R["<b>IL7R</b>"]
    Leukemia{"Leukemia"}
    IL7R -->|"activates"| Leukemia
    Als{"Als"}
    IL7R -->|"activates"| Als
    Fibrosis{"Fibrosis"}
    IL7R -->|"associated with"| Fibrosis
    Ms{"Ms"}
    IL7R -->|"associated with"| Ms
    Inflammation{"Inflammation"}
    IL7R -->|"associated with"| Inflammation
    Senescence{"Senescence"}
    IL7R -->|"therapeutic target"| Senescence
    Aging{"Aging"}
    IL7R -->|"therapeutic target"| Aging
    IL7R -->|"therapeutic target"| Ms
    Autoimmune{"Autoimmune"}
    IL7R -->|"therapeutic target"| Autoimmune
    Lymphoma{"Lymphoma"}
    IL7R -->|"biomarker for"| Lymphoma
    IL7R -->|"biomarker for"| Als
    Tumor{"Tumor"}
    IL7R -->|"inhibits"| Tumor
    TYK2["TYK2"]
    TYK2 -->|"contributes to"| IL7R
    PTK2B["PTK2B"]
    PTK2B -->|"contributes to"| IL7R
    ABL2["ABL2"]
    ABL2 -->|"contributes to"| IL7R
    NTRK3["NTRK3"]
    NTRK3 -->|"contributes to"| IL7R
    ETV6["ETV6"]
    ETV6 -->|"activates"| IL7R
    ABL1["ABL1"]
    ABL1 -->|"contributes to"| IL7R
    PDGFRB["PDGFRB"]
    PDGFRB -->|"contributes to"| IL7R
    GENES["GENES"]
    GENES -->|"activates"| IL7R
    JAK2["JAK2"]
    JAK2 -->|"contributes to"| IL7R
    EPOR["EPOR"]
    EPOR -->|"contributes to"| IL7R
    CSF1R["CSF1R"]
    CSF1R -->|"contributes to"| IL7R
    CXCL8["CXCL8"]
    CXCL8 -->|"associated with"| IL7R
    style IL7R fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (75)

TargetRelationTypeStr
Leukemiaactivatesdisease0.65
Alsactivatesdisease0.65
Fibrosisassociated_withdisease0.65
Msassociated_withdisease0.65
Inflammationassociated_withdisease0.65

Incoming (44)

SourceRelationTypeStr
TYK2contributes_togene0.60
PTK2Bcontributes_togene0.60
NTRK3contributes_togene0.60
PDGFRBcontributes_togene0.60
JAK2contributes_togene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found