Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DRAM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DRAM1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Carcinoma, Lupus, Ms. Connected to 34 entities in the SciDEX knowledge graph.
| Gene Symbol | DRAM1 |
| Full Name | DNA Damage Regulated Autophagy Modulator 1 |
| Chromosome | 7q34 |
| Function | DRAM1 is a lysosomal membrane protein that acts as a key regulator of autophagy, a cellular process critical for clearing misfolded proteins and damaged organelles. |
| Molecular Weight | 37 kDa |
| Pathways | mTOR, mtor |
| UniProt ID | Q8WXX5 |
| NCBI Gene ID | 55332 |
| Ensembl ID | ENSG00000138271 |
| OMIM | 610686 |
| GeneCards | DRAM1 |
| Human Protein Atlas | DRAM1 |
| Approach | Status |
| Autophagy enhancers | Research |
| [mTOR](/entities/mtor) inhibitors | Approved |
| Associated Diseases | Lupus |
| Interactions | VAMP8, SNAP29, STIM1, ULK1, AUTOPHAGY, STX17 |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DRAM1["<b>DRAM1</b>"]
Carcinoma{"Carcinoma"}
DRAM1 -->|"activates"| Carcinoma
Ms{"Ms"}
DRAM1 -->|"activates"| Ms
STUB1["STUB1"]
DRAM1 -->|"regulates"| STUB1
VAMP8["VAMP8"]
DRAM1 -->|"activates"| VAMP8
Autophagy(["Autophagy"])
DRAM1 -->|"interacts with"| Autophagy
AUTOPHAGY["AUTOPHAGY"]
DRAM1 -->|"interacts with"| AUTOPHAGY
SNAP29["SNAP29"]
DRAM1 -->|"activates"| SNAP29
neurodegeneration["neurodegeneration"]
DRAM1 -->|"implicated in"| neurodegeneration
DNA["DNA"]
DNA -->|"regulates"| DRAM1
SNAP29 -->|"activates"| DRAM1
STX17["STX17"]
STX17 -->|"activates"| DRAM1
VAMP8 -->|"activates"| DRAM1
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"regulates"| DRAM1
style DRAM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Carcinoma | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Lupus | associated_with | disease | 0.65 |
| STUB1 | regulates | gene | 0.60 |
| VAMP8 | activates | gene | 0.60 |
| SNAP29 | activates | gene | 0.60 |
| STIM1 | interacts_with | gene | 0.60 |
| STIM1 | activates | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| IFN | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| Immune Response | associated_with | pathway | 0.60 |
| Phagocytosis | associated_with | pathway | 0.60 |
| Adaptive Immunity | associated_with | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Parkinson's disease | activates | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SNAP29 | activates | gene | 0.60 |
| STX17 | activates | gene | 0.60 |
| VAMP8 | activates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| ATG16L2 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| ATG5 | associated_with | gene | 0.60 |
| CDKN1B | associated_with | gene | 0.60 |
| ATG7 | associated_with | gene | 0.60 |
| RUBCN | associated_with | gene | 0.60 |
| CYBB | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| MAP1LC3B | associated_with | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| MTORC1 | associated_with | gene | 0.60 |
| PHAGOCYTOSIS | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||