protein

DRAM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRAM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections
0Hypotheses
0Analyses
19Outgoing
20Incoming

Summary

DRAM1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Carcinoma, Lupus, Ms. Connected to 34 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolDRAM1
Full NameDNA Damage Regulated Autophagy Modulator 1
Chromosome7q34
FunctionDRAM1 is a lysosomal membrane protein that acts as a key regulator of autophagy, a cellular process critical for clearing misfolded proteins and damaged organelles.
Molecular Weight37 kDa
PathwaysmTOR, mtor
UniProt IDQ8WXX5
NCBI Gene ID55332
Ensembl IDENSG00000138271
OMIM610686
GeneCardsDRAM1
Human Protein AtlasDRAM1
ApproachStatus
Autophagy enhancersResearch
[mTOR](/entities/mtor) inhibitorsApproved
Associated DiseasesLupus
InteractionsVAMP8, SNAP29, STIM1, ULK1, AUTOPHAGY, STX17
KG Connections39 knowledge graph edges
DatabasesGeneCardsHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

DRAM1 Gene

gene · 584 words

CDKN1B — Cyclin-Dependent Kinase Inhibitor 1B

gene · 1693 words

ATG16L2 Gene

gene · 1191 words

DRAM2 Gene

gene · 776 words

DRAM1 Protein

protein · 597 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    DRAM1["<b>DRAM1</b>"]
    Carcinoma{"Carcinoma"}
    DRAM1 -->|"activates"| Carcinoma
    Ms{"Ms"}
    DRAM1 -->|"activates"| Ms
    STUB1["STUB1"]
    DRAM1 -->|"regulates"| STUB1
    VAMP8["VAMP8"]
    DRAM1 -->|"activates"| VAMP8
    Autophagy(["Autophagy"])
    DRAM1 -->|"interacts with"| Autophagy
    AUTOPHAGY["AUTOPHAGY"]
    DRAM1 -->|"interacts with"| AUTOPHAGY
    SNAP29["SNAP29"]
    DRAM1 -->|"activates"| SNAP29
    neurodegeneration["neurodegeneration"]
    DRAM1 -->|"implicated in"| neurodegeneration
    DNA["DNA"]
    DNA -->|"regulates"| DRAM1
    SNAP29 -->|"activates"| DRAM1
    STX17["STX17"]
    STX17 -->|"activates"| DRAM1
    VAMP8 -->|"activates"| DRAM1
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"regulates"| DRAM1
    style DRAM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

TargetRelationTypeStr
Carcinomaactivatesdisease0.65
Msactivatesdisease0.65
Lupusassociated_withdisease0.65
STUB1regulatesgene0.60
VAMP8activatesgene0.60

Incoming (20)

SourceRelationTypeStr
SNAP29activatesgene0.60
STX17activatesgene0.60
VAMP8activatesgene0.60
UBIQUITINregulatesgene0.60
ATG16L2associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found