CDKN1B

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDKN1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CDKN1B (p27/Kip1) is a cyclin-dependent kinase inhibitor that regulates G1/S cell cycle transition. It plays critical roles in neurogenesis, neuronal migration, and synaptic plasticity. Dysregulation is implicated in Alzheimer's disease, Parkinson's disease, and cancer.

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graph TD
    CDKN1B["CDKN1B (p27/Kip1)"]
    
    %% Cell cycle regulation
    CDKN1B -->|"inhibits"| CellCycle["Cell Cycle Progression"]
    CellCycle -->|"dysregulation leads to"| Neurodegeneration["Neuronal Death"]
    
    %% Autophagy pathway - key for neurodegeneration
    CDKN1B -->|"regulates"| MTORC1["mTORC1 Complex"]
    MTORC1 -->|"inhibits"| AutophagyInit["Autophagy Initiation"]
    AutophagyInit -->|"activates"| ATG7["ATG7"]
    AutophagyInit -->|"activates"| ATG5["ATG5"]
    ATG7 -->|"forms complex"| LC3["LC3-II Formation"]
    ATG5 -->|"contributes to"| LC3
    LC3 -->|"promotes"| AutophagosomeForm["Autophagosome Formation"]
    
    %% Autophagy regulation genes
    BECN1["BECN1 (Beclin-1)"] -->|"initiates"| AutophagyInit
    DRAM1["DRAM1"] -->|"enhances"| AutophagosomeForm
    RUBCN["RUBCN"] -->|"regulates"| AutophagosomeForm
    
    %% Pathological connections
    LRRK2["LRRK2"] -->|"disrupts"| AutophagyInit
    AutophagosomeForm -->|"clears aggregates"| ProteinAggregates["Protein Aggregates"]
    ProteinAggregates -->|"accumulation causes"| Neurodegeneration
    
    %% Therapeutic implications
    CTSB["CTSB (Cathepsin B)"] -->|"degrades aggregates"| ProteinAggregates
    
    %% Styling
    style CDKN1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style AutophagyInit fill:#1b5e20,stroke:#333
    style AutophagosomeForm fill:#1b5e20,stroke:#333
    style LC3 fill:#1b5e20,stroke:#333
    style CTSB fill:#1b5e20,stroke:#333
    style BECN1 fill:#4a1a6b,stroke:#333
    style ATG7 fill:#4a1a6b,stroke:#333
    style ATG5 fill:#4a1a6b,stroke:#333
    style DRAM1 fill:#4a1a6b,stroke:#333
    style MTORC1 fill:#4a1a6b,stroke:#333
    style LRRK2 fill:#ef5350,stroke:#333
    style Neurodegeneration fill:#ef5350,stroke:#333
    style ProteinAggregates fill:#ef5350,stroke:#333
    style CellCycle fill:#7d4200,stroke:#333