concept

EGFR MUTATIONS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGFR MUTATIONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

115Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

Summary

EGFR MUTATIONS is a concept in neurodegeneration research. Key relationships include: expressed in, associated with, inhibits. Associated with ALS, Als, Cancer. Connected to 87 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	EGFR MUTATIONS
Key Genes/Proteins	EGFR, CANCER
Related Diseases	Als, Carcinoma, Tumor, Cancer, Lymphoma

Pathway Diagram

graph TD
    EGFR_MUTATIONS["EGFR MUTATIONS"]
    EGFR_MUTATIONS -->|"causes"| cancer_progression["cancer progression"]
    EGFR_MUTATIONS -->|"causes"| lung_adenocarcinoma["lung adenocarcinoma"]
    EGFR_MUTATIONS -->|"contributes to"| Carcinoma["Carcinoma"]
    EGFR_MUTATIONS -->|"interacts"| Tumor["Tumor"]
    EGFR_MUTATIONS -->|"target for"| Als["Als"]
    EGFR_MUTATIONS -->|"regulates"| Ms["Ms"]
    EGFR_MUTATIONS -->|"regulates"| Cancer["Cancer"]
    EGFR["EGFR"] -->|"interacts"| EGFR_MUTATIONS
    CANCER["CANCER"] -->|"regulates"| EGFR_MUTATIONS
    AND["AND"] -->|"interacts"| EGFR_MUTATIONS
    IL1B["IL1B"] -->|"expressed in"| EGFR_MUTATIONS
    GENES["GENES"] -->|"expressed in"| EGFR_MUTATIONS
    BCL2L1["BCL2L1"] -->|"expressed in"| EGFR_MUTATIONS
    AKT["AKT"] -->|"expressed in"| EGFR_MUTATIONS
    CYTOKINES["CYTOKINES"] -->|"expressed in"| EGFR_MUTATIONS

Outgoing (81)

Target	Relation	Type	Str
EGFR	inhibits	gene	1.00
Als	associated_with	disease	0.95
Carcinoma	inhibits	disease	0.95
Tumor	therapeutic_target	disease	0.85
Cancer	associated_with	disease	0.85
Lymphoma	inhibits	disease	0.85
Lung Cancer	associated_with	disease	0.85
tumor heterogeneity	contributes_to	phenotype	0.80
CANCER	associated_with	gene	0.80
Cancer	inhibits	disease	0.75
Cancer	therapeutic_target	disease	0.75
Lung Cancer	therapeutic_target	disease	0.75
Lung Cancer	inhibits	disease	0.75
CANCER	therapeutic_target	gene	0.70
EGFR	therapeutic_target	gene	0.70
Carcinoma	contributes_to	disease	0.65
Tumor	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Glioblastoma	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Gastric Cancer	inhibits	disease	0.65
Carcinoma	treats	disease	0.65
Als	interacts_with	disease	0.65
ELF3	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
Akt	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Cell Cycle	associated_with	pathway	0.60
Glycolysis	associated_with	pathway	0.60
Pi3K	associated_with	pathway	0.60
EGFR	regulates	gene	0.60
EGFR	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
EGFR	interacts_with	gene	0.60
GENES	expressed_in	gene	0.60
BCL2L1	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
ELF3	expressed_in	gene	0.60

Incoming (34)

Source	Relation	Type	Str
AKT	associated_with	gene	0.60
BCL2L1	associated_with	gene	0.60
EGFR	interacts_with	gene	0.60
CANCER	regulates	gene	0.60
CANCER	inhibits	gene	0.60
CANCER	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
BCL2L1	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
ELF3	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
EGFR	activates	gene	0.60
CANCER	activates	gene	0.60
AKT	activates	gene	0.60
EGFR	treats	gene	0.60
OVERVIEW	treats	gene	0.60
GLIOBLASTOMA	inhibits	gene	0.60
CANCER	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
AND	activates	gene	0.60
AND	inhibits	gene	0.60
EGFR	inhibits	gene	0.60
MET	therapeutic_target	gene	0.60
FLAVONOIDS	therapeutic_target	gene	0.60
EGF	inhibits	gene	0.60
CCND1	expressed_in	gene	0.60
EGFR	associated_with	gene	0.50
TUMOR	associated_with	disease	0.50
TUMOR	interacts_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found