EPHA4

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHA4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

EPHA4 (Eph Receptor A4) - a receptor tyrosine kinase involved in synaptic plasticity, NMJ formation, axon guidance, and neurodegenerative diseases including Alzheimer's disease and ALS

View on Wiki →

graph TD
    EPHA4["<b>EPHA4</b>"]
    Neurodegeneration{"Neurodegeneration"}
    EPHA4 -->|"associated with"| Neurodegeneration
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    EPHA4 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    Dementia{"Dementia"}
    EPHA4 -->|"associated with"| Dementia
    Als{"Als"}
    EPHA4 -->|"associated with"| Als
    Inflammation{"Inflammation"}
    EPHA4 -->|"associated with"| Inflammation
    Ms{"Ms"}
    EPHA4 -->|"associated with"| Ms
    EPHA4 -->|"activates"| Als
    EPHA4 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    EPHA4 -->|"activates"| Ms
    Neuroinflammation{"Neuroinflammation"}
    EPHA4 -->|"expressed in"| Neuroinflammation
    EPHA4 -->|"expressed in"| Ms
    EPHA4 -->|"regulates"| Inflammation
    STAT6["STAT6"]
    STAT6 -->|"expressed in"| EPHA4
    SLC22A4["SLC22A4"]
    SLC22A4 -->|"expressed in"| EPHA4
    TLR4["TLR4"]
    TLR4 -->|"expressed in"| EPHA4
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"expressed in"| EPHA4
    ERK["ERK"]
    ERK -->|"expressed in"| EPHA4
    MERTK["MERTK"]
    MERTK -->|"expressed in"| EPHA4
    GFP["GFP"]
    GFP -->|"expressed in"| EPHA4
    AXON["AXON"]
    AXON -->|"inhibits"| EPHA4
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"inhibits"| EPHA4
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"expressed in"| EPHA4
    BRAIN_INJURY["BRAIN INJURY"]
    BRAIN_INJURY -->|"regulates"| EPHA4
    AND["AND"]
    AND -->|"expressed in"| EPHA4
    style EPHA4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0