Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Epithelial-Mesenchymal Transition: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | Epithelial-Mesenchymal Transition |
| Key Genes/Proteins | CANCER, PI3K, AKT, AUTOPHAGY, NTN1, EFNB1 |
| Related Diseases | Tumor, Cancer, Als |
| Related Pathways | Notch Signaling Pathway, Netrin-1 Blockade |
Knowledge base pages for this entity
graph TD
Epithelial_Mesenchymal_Transit["<b>Epithelial-Mesenchymal Transition</b>"]
Esophageal_Squamous_Cell_Carci{"Esophageal Squamous-Cell Carcinoma"}
Epithelial_Mesenchymal_Transit -->|"contributes_to"| Esophageal_Squamous_Cell_Carci
CANCER(["CANCER"])
CANCER -->|"activates"| Epithelial_Mesenchymal_Transit
Tumor{"Tumor"}
Tumor -->|"therapeutic_target"| Epithelial_Mesenchymal_Transit
Cancer{"Cancer"}
Cancer -->|"activates"| Epithelial_Mesenchymal_Transit
PI3K(["PI3K"])
PI3K -->|"regulates"| Epithelial_Mesenchymal_Transit
style Epithelial_Mesenchymal_Transit fill:#1a3a4a,stroke:#90a4ae,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Esophageal Squamous-Cell Carcinoma | contributes_to | disease | 0.90 |
| Cancer Metastasis | contributes_to | phenotype | 0.90 |
| Esophageal Squamous Cell Carcinoma | contributes_to | disease | 0.90 |
| Nasopharyngeal Carcinoma metastasis | associated_with | phenotype | 0.90 |
| Cancer Proliferation | contributes_to | phenotype | 0.85 |
| Cancer Invasion | contributes_to | phenotype | 0.85 |
| Esophageal Squamous Cell Carcinoma | promotes | disease | 0.85 |
| EXTRACELLULAR MATRIX | activates | concept | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| CELL MIGRATION | activates | concept | 0.50 |
| MTOR SIGNALING | activates | concept | 0.50 |
| CELL PROLIFERATION | activates | concept | 0.50 |
| METFORMIN | inhibits | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | activates | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| PI3K | regulates | gene | 1.00 |
| AKT | regulates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NTN1 | inhibits | gene | 0.95 |
| Notch Signaling Pathway | associated_with | pathway | 0.95 |
| Netrin-1 Blockade | inhibits | mechanism | 0.95 |
| EFNB1 | promotes | gene | 0.95 |
| EPHB4 | promotes | gene | 0.95 |
| LRP1 | associated_with | gene | 0.90 |
| β-Adrenergic Signaling | associated_with | pathway | 0.90 |
| Notch Signaling Pathway | promotes | pathway | 0.90 |
| Netrin-1 Inhibitor | suppresses | drug | 0.90 |
| NTN1 | promotes | protein | 0.90 |
| FLOT1 | modulates | protein | 0.90 |
| EFNB1 | associated_with | gene | 0.90 |
| EPHB4 | associated_with | gene | 0.90 |
| SATB2 | inhibits | protein | 0.90 |
| APOPTOSIS | activates | gene | 0.90 |
| MTOR | regulates | gene | 0.90 |
| CANCER | inhibits | gene | 0.90 |
| Breast Cancer | inhibits | disease | 0.90 |
| Cancer | inhibits | disease | 0.90 |
| Carcinoma | activates | disease | 0.90 |
| Ononin | inhibits | compound | 0.88 |
| Metformin | inhibits | drug | 0.85 |
| Akt/Mtor | activates | pathway | 0.85 |
| Luteolin | inhibits | compound | 0.85 |
| Beta-adrenergic Signaling | associated_with | pathway | 0.85 |
| TUBB3 | promotes | gene | 0.85 |
| PI3K/AKT pathway | drives | pathway | 0.85 |
| PI3K/AKT | regulates | pathway | 0.85 |
| SATB2 | suppresses | protein | 0.83 |
| NP137 | inhibits | drug | 0.80 |
| Autophagy | involved_in | process | 0.80 |
| Autophagy | regulates | process | 0.80 |
| APOPTOSIS | regulates | gene | 0.80 |
| Tumor | inhibits | disease | 0.80 |
| CANCER | associated_with | gene | 0.80 |
| Cancer | associated_with | disease | 0.80 |
| carboplatin-paclitaxel | associated_with | drug | 0.70 |
| Als | regulates | disease | 0.70 |
| NF-ΚB | regulates | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||