Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FGF7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FGF7 (Fibroblast Growth Factor 7), also known as keratinocyte growth factor (KGF), is a paracrine growth factor that promotes epithelial cell proliferation, tissue repair, and has neuroprotective effects in the nervous system. Implicated in Alzheimer's disease, Parkinson's disease, and neural development.
| Gene Symbol | FGF7 |
| Full Name | Fibroblast Growth Factor 7 |
| Chromosome | 19p13.3 |
| Protein Type | Secreted growth factor |
| Function | is a member of the fibroblast growth factor family that functions primarily as a paracrine growth factor[@finch1998]. |
| Primary Expression | various tissues including skin, lung, gastrointestinal tract, and brain, where it plays critical roles in tissue repair, morphogenesis, and cellular s |
| Molecular Weight | ~26 kDa |
| Amino Acids | 194 aa |
| Pathways | MAPK pathway, PI3K |
| UniProt ID | P21781 |
| NCBI Gene ID | 2254 |
| Ensembl ID | ENSG00000145681 |
| OMIM | 148180 |
| GeneCards | FGF7 |
| Human Protein Atlas | FGF7 |
| Associated Diseases | Als |
| Interactions | FGFR2, PARKINSON, ASTROCYTES, PARKINSON'S DISEASE, ASTROCYTE, Fgf |
| KG Connections | 48 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FGF7["<b>FGF7</b>"]
TRKB["TRKB"]
TRKB -->|"regulates"| FGF7
NTRK2["NTRK2"]
NTRK2 -->|"regulates"| FGF7
Parkinson["Parkinson"]
FGF7 -->|"activates"| Parkinson
Neuroinflammation["Neuroinflammation"]
FGF7 -->|"activates"| Neuroinflammation
Inflammation["Inflammation"]
FGF7 -->|"activates"| Inflammation
ASTROCYTES["ASTROCYTES"]
FGF7 -->|"activates"| ASTROCYTES
Dopaminergic["Dopaminergic"]
FGF7 -->|"activates"| Dopaminergic
Fibroblast["Fibroblast"]
FGF7 -->|"associated with"| Fibroblast
Neuron["Neuron"]
FGF7 -->|"activates"| Neuron
Astrocyte["Astrocyte"]
FGF7 -->|"activates"| Astrocyte
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
FGF7 -->|"activates"| PARKINSON_S_DISEASE
Astrocyte_Reactivity["Astrocyte Reactivity"]
FGF7 -->|"associated with"| Astrocyte_Reactivity
ASTROCYTE["ASTROCYTE"]
ASTROCYTE -->|"activates"| FGF7
FGFR2["FGFR2"]
FGFR2 -->|"activates"| FGF7
NEUROINFLAMMATION["NEUROINFLAMMATION"]
NEUROINFLAMMATION -->|"activates"| FGF7
INFLAMMATION["INFLAMMATION"]
INFLAMMATION -->|"activates"| FGF7
PARKINSON["PARKINSON"]
PARKINSON -->|"activates"| FGF7
FGF["FGF"]
FGF -->|"activates"| FGF7
AND["AND"]
AND -->|"activates"| FGF7
Fibroblast["Fibroblast"]
FGF7 -->|"expressed in"| Fibroblast
Astrocyte["Astrocyte"]
FGF7 -->|"expressed in"| Astrocyte
Neuron["Neuron"]
FGF7 -->|"expressed in"| Neuron
FGFR2["FGFR2"]
FGF7 -->|"activates"| FGFR2
NEURON["NEURON"]
FGF7 -->|"co discussed"| NEURON
PARKIN["PARKIN"]
FGF7 -->|"co discussed"| PARKIN
PARKINSON["PARKINSON"]
FGF7 -->|"activates"| PARKINSON
neurodegeneration["neurodegeneration"]
FGF7 -->|"implicated in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Astrocyte Reactivity | associated_with | pathway | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| Dopaminergic | activates | cell_type | 0.60 |
| Fibroblast | associated_with | cell_type | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| Astrocyte | activates | cell_type | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| Fgf | activates | protein | 0.60 |
| RAS | activates | gene | 0.60 |
| Epithelial | expressed_in | cell_type | 0.60 |
| Pi3K | activates | protein | 0.60 |
| Actin | activates | protein | 0.60 |
| Akt | activates | protein | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| Fibroblast | expressed_in | cell_type | 0.55 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| FGFR2 | activates | gene | 0.50 |
| PARKIN | co_discussed | gene | 0.50 |
| FGFR2 | associated_with | gene | 0.50 |
| NEURON | co_discussed | gene | 0.50 |
| PARKINSON | activates | gene | 0.50 |
| inflammation | activates | pathway | 0.50 |
| NEURONS | activates | concept | 0.50 |
| DOPAMINERGIC | activates | concept | 0.50 |
| DOPAMINERGIC NEURONS | activates | concept | 0.50 |
| inflammation | associated_with | pathway | 0.50 |
| Astrocyte | associated_with | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TRKB | regulates | protein | 0.70 |
| NTRK2 | regulates | protein | 0.70 |
| FGFR2 | activates | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| NEUROINFLAMMATION | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| FGF | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| FGF | associated_with | gene | 0.60 |
| Neuroinflammation | activates | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||