concept

LYSOSOMAL BIOGENESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYSOSOMAL BIOGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

356Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

LYSOSOMAL BIOGENESIS is a concept in neurodegeneration research. Key relationships include: activates, regulates, causes. Associated with Aging, Als, Alzheimer. Connected to 250 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	LYSOSOMAL BIOGENESIS
Key Genes/Proteins	C9ORF72, AUTOPHAGY, LYSOSOME, TSC2, NEURODEGENERATION, MTOR
Related Diseases	Als, Tumor, Neurodegeneration
Related Pathways	Autophagy, Mtor
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"]
    LYSOSOMAL_BIOGENESIS -->|"regulates"| Als["Als"]
    LYSOSOMAL_BIOGENESIS -->|"regulates"| Ms["Ms"]
    LYSOSOMAL_BIOGENESIS -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    LYSOSOMAL_BIOGENESIS -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    LYSOSOMAL_BIOGENESIS -->|"expressed in"| Dementia["Dementia"]
    LYSOSOMAL_BIOGENESIS -->|"activates"| Tumor["Tumor"]
    LYSOSOMAL_BIOGENESIS -->|"activates"| Ischemia["Ischemia"]
    C9ORF72["C9ORF72"] -->|"regulates"| LYSOSOMAL_BIOGENESIS
    mTOR["mTOR"] -->|"regulates"| LYSOSOMAL_BIOGENESIS
    TFEB["TFEB"] -->|"regulates"| LYSOSOMAL_BIOGENESIS
    NRF2["NRF2"] -->|"activates"| LYSOSOMAL_BIOGENESIS
    MICROGLIA["MICROGLIA"] -->|"regulates"| LYSOSOMAL_BIOGENESIS
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| LYSOSOMAL_BIOGENESIS
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"interacts"| LYSOSOMAL_BIOGENESIS
    VESICLE_TRAFFICKING["VESICLE TRAFFICKING"] -->|"interacts"| LYSOSOMAL_BIOGENESIS
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| LYSOSOMAL_BIOGENESIS

Outgoing (205)

Target	Relation	Type	Str
AUTOPHAGY	regulates	gene	0.90
Autophagy	regulates	pathway	0.90
LYSOSOME	activates	gene	0.80
Als	regulates	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Neurodegeneration	causes	disease	0.75
Autophagy	activates	pathway	0.70
TSC2	activates	gene	0.70
Mtor	regulates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Mtor	activates	pathway	0.70
NEURODEGENERATION	causes	gene	0.70
MTOR	activates	gene	0.70
MTOR	regulates	gene	0.70
Alzheimer	associated_with	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Ms	activates	disease	0.65
Ischemia	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Senescence	regulates	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Dementia	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Alzheimer	causes	disease	0.65
Als	causes	disease	0.65
Huntington	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Breast Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Aging	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65

Incoming (151)

Source	Relation	Type	Str
C9ORF72	regulates	gene	0.90
TFEB	activates	gene	0.70
TFEB	regulates	gene	0.70
MICROGLIA	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
MOTOR NEURONS	interacts_with	gene	0.60
VESICLE TRAFFICKING	interacts_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
AMPK	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MTOR	regulates	gene	0.60
DMSO	activates	gene	0.60
MTOR	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
TFEB	expressed_in	gene	0.60
AUTOPHAGY	expressed_in	gene	0.60
TREHALOSE	activates	gene	0.60
AGING	regulates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
P62	activates	gene	0.60
TUBULIN	activates	gene	0.60
JUN	activates	gene	0.60
LC3	activates	gene	0.60
LYSOSOME	activates	gene	0.60
CHMP2B	causes	gene	0.60
C9ORF72	interacts_with	gene	0.60
FIG4	causes	gene	0.60
C9ORF72 REPEAT EXPANSION	causes	gene	0.60
ALS2	causes	gene	0.60
NEURON	interacts_with	gene	0.60
GAIN	causes	gene	0.60
RAB5	causes	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
GFP	activates	gene	0.60
AKT	activates	gene	0.60
ENDOSOMES	activates	gene	0.60
GENES	regulates	gene	0.60
MAP1LC3B	activates	gene	0.60
TUBB3	activates	gene	0.60
CTSD	activates	gene	0.60
ATG7	activates	gene	0.60
SYN1	activates	gene	0.60
SQSTM1	activates	gene	0.60
RAB5	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LYSOSOMAL BIOGENESIS

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Novel Therapy Index

Neuroresilience Mechanisms and Evidence

CBS/PSP Treatment Rankings

Mitochondrial Quality Control

Autophagy Mechanisms

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

Neuronal Ceroid Lipofuscinosis (NCL)

Neuroprotection Strategies in Neurodegeneration

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Genistein for Mild Cognitive Impairment (NCT07385937)

rapamycin-tauopathy

gba

Transcriptional Regulation in Neurodegeneration

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

Lysosomal Dysfunction in Neurodegeneration

autophagy-lysosomal-alzheimers

ubiquitin-proteasome-dysfunction-neurodegeneration