MAP3K5

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP3K5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for MAP3K5 — Mitogen-Activated Protein Kinase Kinase Kinase 5

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flowchart TD
    MAP3K5["MAP3K5<br/>(ASK1 Kinase)"]
    
    %% Stress Response
    MAP3K5 --|"activates"|--> TP53["TP53<br/>(Tumor Suppressor)"]
    MAP3K5 --|"regulates"|--> H2AX["H2AX<br/>(DNA Damage Response)"]
    MAP3K5 --|"interacts_with"|--> NFE2L2["NFE2L2<br/>(Nrf2 Antioxidant)"]
    
    %% Autophagy Regulation
    MAP3K5 --|"regulates"|--> Autophagy["Autophagy<br/>Pathway"]
    MAP3K5 --|"regulates"|--> BECN1["BECN1<br/>(Autophagy Initiator)"]
    MAP3K5 --|"regulates"|--> ATG14["ATG14<br/>(Autophagy Complex)"]
    MAP3K5 --|"interacts_with"|--> MTOR["MTOR<br/>(Growth Regulator)"]
    MTOR --|"inhibits"|--> Autophagy
    
    %% Protein Quality Control
    MAP3K5 --|"regulates"|--> UPS["Ubiquitin-Proteasome<br/>System"]
    MAP3K5 --|"regulates"|--> Proteasome["Proteasome<br/>Pathway"]
    MAP3K5 --|"associated_with"|--> LAMP1["LAMP1<br/>(Lysosomal Marker)"]
    
    %% Mitochondrial Function
    MAP3K5 --|"interacts_with"|--> SIRT3["SIRT3<br/>(Mitochondrial Deacetylase)"]
    MAP3K5 --|"interacts_with"|--> HTRA2["HTRA2<br/>(Mitochondrial Protease)"]
    
    %% Cellular Outcomes
    TP53 --|"leads_to"|--> Apoptosis["Cell Death<br/>(Apoptosis)"]
    Autophagy --|"promotes"|--> Neuroprotection["Neuroprotection<br/>(Protein Clearance)"]
    UPS --|"promotes"|--> Neuroprotection
    
    %% Pathological Processes
    MAP3K5 --|"contributes_to"|--> Neurodegeneration["Neurodegeneration<br/>(Disease State)"]
    H2AX --|"indicates"|--> DNADamage["DNA Damage<br/>(Cellular Stress)"]
    DNADamage --|"leads_to"|--> Neurodegeneration
    
    style MAP3K5 fill:#006494
    style NFE2L2 fill:#1b5e20
    style SIRT3 fill:#1b5e20
    style Autophagy fill:#1b5e20
    style Neuroprotection fill:#1b5e20
    style TP53 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style BECN1 fill:#4a1a6b
    style Apoptosis fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style DNADamage fill:#ef5350
    style UPS fill:#5d4400
    style Proteasome fill:#5d4400