gene

RPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

463Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for RPTOR — Regulatory Associated Protein of MTOR Complex 1

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🧬 Gene Info

Gene Symbol	RPTOR
Full Name	Regulatory Associated Protein of MTOR Complex 1
Chromosome	17q25.3.
Function	is an essential scaffolding component of the mTOR Complex 1 (mTORC1), located on chromosome 17q25.
Primary Expression	Hippocampus, Cortex, Cerebellum, Substantia nigra (ubiquitous)
Amino Acids	335 aa
Exons	30
Pathways	MTOR, mTOR, AMPK, mtor, mTOR pathway
UniProt ID	Q8N122
NCBI Gene ID	57521
Ensembl ID	ENSG00000141564
OMIM	607592
GeneCards	RPTOR
Human Protein Atlas	RPTOR
Symbol [@tramutola2018] RPTOR [@malagelada2010] [@saxton2017] [@tang2019] Full Name [@bov2011] Regulatory Associated Protein of MTOR Complex 1 (Raptor) Chromosome	17q25.3
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, Tuberous Sclerosis
Known Drugs/Compounds	rapamycin
Interactions	RB1, EIF2AK3, RIPK1, MAPK14, BECN1, ATF6
KG Connections	463 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RPTOR — AlphaFold Q8N122 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RPTOR["RPTOR"] -->|"Interacts With"| Cancer["Cancer"]
    RPTOR["RPTOR"] -->|"Interacts With"| Als["Als"]
    RPTOR["RPTOR"] -->|"Interacts With"| Ms["Ms"]
    RPTOR["RPTOR"] -->|"Interacts With"| Fibrosis["Fibrosis"]
    RPTOR["RPTOR"] -->|"Interacts With"| Tumor["Tumor"]
    RPTOR["RPTOR"] -->|"Interacts With"| Hepatitis["Hepatitis"]
    RPTOR["RPTOR"] -->|"Interacts With"| RB1["RB1"]
    RPTOR["RPTOR"] -->|"Interacts With"| EIF2AK3["EIF2AK3"]
    OPTN["OPTN"] -->|"Interacts With"| RPTOR["RPTOR"]
    CASP3["CASP3"] -->|"Interacts With"| RPTOR["RPTOR"]
    AKT1["AKT1"] -->|"Interacts With"| RPTOR["RPTOR"]
    CALCOCO2["CALCOCO2"] -->|"Interacts With"| RPTOR["RPTOR"]
    CGAS["CGAS"] -->|"Interacts With"| RPTOR["RPTOR"]
    style RPTOR fill:#8d4900,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Hepatitis fill:#b71c1c,color:#e0e0e0
    style RB1 fill:#8d4900,color:#e0e0e0
    style EIF2AK3 fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style CASP3 fill:#8d4900,color:#e0e0e0
    style AKT1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style CGAS fill:#8d4900,color:#e0e0e0

Outgoing (242)

Target	Relation	Type	Str
MTOR	component_of	protein	0.95
MTOR	binds	protein	0.90
MTORC1	component_of	entity	0.90
MTORC1	regulates	entity	0.90
cell size	regulates	phenotype	0.80
MTOR	inhibits	protein	0.80
S6K1	regulates	protein	0.80
autophagy pathway	participates_in	pathway	0.70
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Ms	contributes_to	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
ALS	regulates	disease	0.65
RB1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60

Incoming (221)

Source	Relation	Type	Str
RRAGA	binds	gene	0.90
EP300	phosphorylates	protein	0.85
TARDBP	regulates	gene	0.80
P300	phosphorylates	protein	0.80
MTORC1	activates	gene	0.70
rapamycin	targets	drug	0.70
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
EIF2A	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RPTOR

Understanding Entity Pages

Summary

Wiki Pages (21)

RPTOR — Regulatory Associated Protein of MTOR Complex 1

autophagy-lysosome-dysfunction

mTOR Signaling in Autophagy and Lysosomal Function

RRAGA — Ras-Related GTP Binding A

TARDBP Protein (TDP-43)

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

NR1H3 - Nuclear Receptor Subfamily 1 Group H Member 3

P300 Brain-Computer Interface

atg16l1

MLST8 Protein

LXR-alpha Protein

KDM6B (JMJD3)

EIF2α Protein

IFNG Gene

mTORC1 Protein — Mechanistic Target of Rapamycin Complex 1

RPTOR Protein

Raptor Protein

IFN-γ Protein

RHEB Protein