Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ELAVL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ELAVL1 (HuR) RNA-binding protein involved in mRNA stability, synaptic plasticity, and neurodegenerative disease mechanisms
| Gene Symbol | ELAVL1 |
| Full Name | ELAVL1 |
| Chromosome | 19p13.2 |
| Protein Type | Gene |
| Function | is a member of the ELAV (Embryonic Lethal Abnormal Vision) family of RNA-binding proteins. |
| Primary Expression | neurons throughout the central and peripheral nervous systems: |
| Subcellular Localization | and RNA binding activity[@lee2020] |
| Molecular Weight | 36 kDa |
| Amino Acids | 326 aa |
| Exons | 10 |
| Pathways | Autophagy, Ferroptosis, Proteasome, Ubiquitin-Proteasome |
| NCBI Gene ID | Search NCBI |
| GeneCards | ELAVL1 |
| Human Protein Atlas | ELAVL1 |
| Associated Diseases | Carcinoma, Hepatocellular Carcinoma, Tumor |
| Interactions | BECLIN1, BECN1, NSUN2, YBX1, ATF3, UBIQUITIN |
| KG Connections | 108 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
ELAVL1["<b>ELAVL1</b>"]
Cancer{"Cancer"}
ELAVL1 -->|"activates"| Cancer
Carcinoma{"Carcinoma"}
ELAVL1 -->|"activates"| Carcinoma
ELAVL1 -->|"associated with"| Carcinoma
Tumor{"Tumor"}
ELAVL1 -->|"associated with"| Tumor
Ms{"Ms"}
ELAVL1 -->|"interacts with"| Ms
Fibrosis{"Fibrosis"}
ELAVL1 -->|"activates"| Fibrosis
ELAVL1 -->|"therapeutic target"| Fibrosis
Als{"Als"}
ELAVL1 -->|"activates"| Als
ELAVL1 -->|"therapeutic target"| Ms
GPX4["GPX4"]
ELAVL1 -->|"associated with"| GPX4
ATG["ATG"]
ELAVL1 -->|"associated with"| ATG
FN1["FN1"]
ELAVL1 -->|"associated with"| FN1
NSUN2["NSUN2"]
NSUN2 -->|"activates"| ELAVL1
YBX1["YBX1"]
YBX1 -->|"interacts with"| ELAVL1
SQSTM1["SQSTM1"]
SQSTM1 -->|"associated with"| ELAVL1
TNF["TNF"]
TNF -->|"associated with"| ELAVL1
ATF3["ATF3"]
ATF3 -->|"activates"| ELAVL1
GOT1["GOT1"]
GOT1 -->|"associated with"| ELAVL1
GPT["GPT"]
GPT -->|"associated with"| ELAVL1
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"activates"| ELAVL1
TP53["TP53"]
TP53 -->|"associated with"| ELAVL1
NCOA4["NCOA4"]
NCOA4 -->|"associated with"| ELAVL1
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"interacts with"| ELAVL1
AND["AND"]
AND -->|"activates"| ELAVL1
style ELAVL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| mRNA Stability | mediates | process | 0.85 |
| Carcinoma | associated_with | disease | 0.75 |
| Hepatocellular Carcinoma | associated_with | disease | 0.75 |
| FTH1 | associated_with | gene | 0.70 |
| P62 | associated_with | gene | 0.70 |
| PTGS2 | associated_with | gene | 0.70 |
| NCOA4 | associated_with | gene | 0.70 |
| SQSTM1 | associated_with | gene | 0.70 |
| ATG | associated_with | gene | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| COL1A1 | associated_with | gene | 0.70 |
| ROS | associated_with | gene | 0.70 |
| Cancer | activates | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Fibrosis | therapeutic_target | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| GPX4 | associated_with | gene | 0.60 |
| SLC7A11 | associated_with | gene | 0.60 |
| MAP1LC3A | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| BECLIN1 | activates | gene | 0.60 |
| MAP1LC3B | associated_with | gene | 0.60 |
| TGFB1 | associated_with | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| ACTB | associated_with | gene | 0.60 |
| NSUN2 | activates | gene | 0.60 |
| YBX1 | interacts_with | gene | 0.60 |
| ATF3 | activates | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| GOT1 | associated_with | gene | 0.60 |
| GPT | associated_with | gene | 0.60 |
| YBX1 | therapeutic_target | entity | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| F3 | activates | gene | 0.60 |
| FTH1 | interacts_with | gene | 0.60 |
| GOT1 | interacts_with | gene | 0.60 |
| GPT | interacts_with | gene | 0.60 |
| GPX4 | interacts_with | gene | 0.60 |
| MAP1LC3B | interacts_with | gene | 0.60 |
| NCOA4 | interacts_with | gene | 0.60 |
| PTGS2 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| TGFB1 | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GPX4 | associated_with | gene | 0.70 |
| NSUN2 | activates | gene | 0.60 |
| YBX1 | interacts_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| ATF3 | activates | gene | 0.60 |
| GOT1 | associated_with | gene | 0.60 |
| GPT | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| NCOA4 | associated_with | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| BECN1 | interacts_with | gene | 0.60 |
| ABCA7 | expressed_in | gene | 0.60 |
| ARF1 | expressed_in | gene | 0.60 |
| ATG7 | expressed_in | gene | 0.60 |
| E2F2 | expressed_in | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| HDGF | activates | gene | 0.60 |
| RNA | interacts_with | gene | 0.60 |
| ATG | interacts_with | gene | 0.60 |
| COL1A1 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||