gene

ELAVL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ELAVL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

109Connections
0Hypotheses
0Analyses
50Outgoing
23Incoming

Summary

ELAVL1 (HuR) RNA-binding protein involved in mRNA stability, synaptic plasticity, and neurodegenerative disease mechanisms

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🧬 Gene Info
Gene SymbolELAVL1
Full NameELAVL1
Chromosome19p13.2
Protein TypeGene
Functionis a member of the ELAV (Embryonic Lethal Abnormal Vision) family of RNA-binding proteins.
Primary Expressionneurons throughout the central and peripheral nervous systems:
Subcellular Localizationand RNA binding activity[@lee2020]
Molecular Weight36 kDa
Amino Acids326 aa
Exons10
PathwaysAutophagy, Ferroptosis, Proteasome, Ubiquitin-Proteasome
NCBI Gene IDSearch NCBI
GeneCardsELAVL1
Human Protein AtlasELAVL1
Associated DiseasesCarcinoma, Hepatocellular Carcinoma, Tumor
InteractionsBECLIN1, BECN1, NSUN2, YBX1, ATF3, UBIQUITIN
KG Connections108 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

ELAVL1 Gene

gene · 1559 words

RNA Metabolism Dysregulation in Alzheimer's Disease

mechanism · 4024 words

GPT - Alanine Transaminase (ALT)

gene · 3393 words

NSUN2 Gene

gene · 3064 words

HNRNPUL2 Gene

gene · 2092 words

GOT1 Gene

gene · 1853 words

Pathway Diagram

graph TD
    ELAVL1["<b>ELAVL1</b>"]
    Cancer{"Cancer"}
    ELAVL1 -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    ELAVL1 -->|"activates"| Carcinoma
    ELAVL1 -->|"associated with"| Carcinoma
    Tumor{"Tumor"}
    ELAVL1 -->|"associated with"| Tumor
    Ms{"Ms"}
    ELAVL1 -->|"interacts with"| Ms
    Fibrosis{"Fibrosis"}
    ELAVL1 -->|"activates"| Fibrosis
    ELAVL1 -->|"therapeutic target"| Fibrosis
    Als{"Als"}
    ELAVL1 -->|"activates"| Als
    ELAVL1 -->|"therapeutic target"| Ms
    GPX4["GPX4"]
    ELAVL1 -->|"associated with"| GPX4
    ATG["ATG"]
    ELAVL1 -->|"associated with"| ATG
    FN1["FN1"]
    ELAVL1 -->|"associated with"| FN1
    NSUN2["NSUN2"]
    NSUN2 -->|"activates"| ELAVL1
    YBX1["YBX1"]
    YBX1 -->|"interacts with"| ELAVL1
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| ELAVL1
    TNF["TNF"]
    TNF -->|"associated with"| ELAVL1
    ATF3["ATF3"]
    ATF3 -->|"activates"| ELAVL1
    GOT1["GOT1"]
    GOT1 -->|"associated with"| ELAVL1
    GPT["GPT"]
    GPT -->|"associated with"| ELAVL1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| ELAVL1
    TP53["TP53"]
    TP53 -->|"associated with"| ELAVL1
    NCOA4["NCOA4"]
    NCOA4 -->|"associated with"| ELAVL1
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"interacts with"| ELAVL1
    AND["AND"]
    AND -->|"activates"| ELAVL1
    style ELAVL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (86)

TargetRelationTypeStr
mRNA Stabilitymediatesprocess0.85
Carcinomaassociated_withdisease0.75
Hepatocellular Carcinomaassociated_withdisease0.75
FTH1associated_withgene0.70
P62associated_withgene0.70

Incoming (23)

SourceRelationTypeStr
GPX4associated_withgene0.70
NSUN2activatesgene0.60
YBX1interacts_withgene0.60
SQSTM1associated_withgene0.60
TNFassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found