concept

HTTLPR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTTLPR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

39Outgoing

27Incoming

Summary

HTTLPR is a concept in neurodegeneration research. Key relationships include: associated with, activates. Associated with ALS, Als, Bipolar. Connected to 56 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HTTLPR
Key Genes/Proteins	MITOCHONDRIAL DNA, BDNF, PERIOD3, HTR2A, GRM4, G72
Related Diseases	Depression, Bipolar, Schizophrenia, Als, Ms

Wiki Pages (12)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HTTLPR["<b>HTTLPR</b>"]
    HTTLPR -->|"activates"| Depression["Depression"]
    HTTLPR -->|"activates"| Ms["Ms"]
    HTTLPR -->|"activates"| BDNF["BDNF"]
    HTTLPR -->|"activates"| DEPRESSION["DEPRESSION"]
    HTTLPR -->|"activates"| AND["AND"]
    BDNF -->|"activates"| HTTLPR
    DEPRESSION -->|"activates"| HTTLPR

Outgoing (39)

Target	Relation	Type	Str
Depression	activates	disease	0.65
Bipolar	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	activates	disease	0.65
ALS	associated_with	disease	0.65
MITOCHONDRIAL DNA	associated_with	gene	0.60
BDNF	activates	gene	0.60
PERIOD3	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
G72	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
DAO	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
PDLIM5	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
POLG	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
DNA	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
Circadian Rhythm	associated_with	pathway	0.60
CIRCADIAN RHYTHM	associated_with	gene	0.60
DEPRESSION	activates	gene	0.60
AND	activates	gene	0.60
Rb	associated_with	protein	0.60
App	associated_with	protein	0.60
DEPRESSION	associated_with	disease	0.56
SEROTONIN	activates	concept	0.50

Incoming (27)

Source	Relation	Type	Str
BDNF	activates	gene	0.60
BMAL1	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
DNA	associated_with	gene	0.60
DAO	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
DEPRESSION	activates	gene	0.60
GRIN2B	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
PERIOD3	associated_with	gene	0.60
POLG	associated_with	gene	0.60
G72	associated_with	gene	0.60
TPH2	associated_with	gene	0.60
PDLIM5	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
AND	activates	gene	0.60
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HTTLPR

Understanding Entity Pages

Summary

Wiki Pages (12)

Serotonergic Dysfunction in Neurodegeneration

Serotonin Signaling Pathway in Neurodegeneration

Section 160: Pharmacogenomics and Personalized Medicine in CBS/PSP

Serotonergic System in Neurodegeneration

SLC6A4 Gene — Serotonin Transporter

Citalopram Depression AD Trial

Serotonin (5-Hydroxytryptamine, 5-HT)

Median Raphe Serotonergic Neurons

Serotonergic Neurons (Raphe Nuclei)

Serotonin Transporter (SERT) Neurons