Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HTR2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HTR2A is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with ALS, Als, Bipolar. Connected to 60 entities in the SciDEX knowledge graph.
| Gene Symbol | HTR2A |
| Full Name | 5-Hydroxytryptamine Receptor 2A |
| Chromosome | 13q14.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Cortex, Platelets, Smooth muscle, Olfactory bulb |
| Molecular Weight | 60 kDa |
| UniProt ID | P28223 |
| NCBI Gene ID | 3352 |
| Ensembl ID | ENSG00000102468 |
| GeneCards | HTR2A |
| Human Protein Atlas | HTR2A |
| Associated Diseases | ALS, Alzheimer, Autism, Bipolar, Cancer |
| Interactions | HTR2C, SLC1A1, SLC6A2, CACNA1H, GABRB2, GRIA1 |
| KG Connections | 150 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HTR2A["<b>HTR2A</b>"]
Schizophrenia{"Schizophrenia"}
HTR2A -->|"associated with"| Schizophrenia
Als{"Als"}
HTR2A -->|"associated with"| Als
Depression{"Depression"}
HTR2A -->|"associated with"| Depression
Bipolar{"Bipolar"}
HTR2A -->|"associated with"| Bipolar
Ms{"Ms"}
HTR2A -->|"associated with"| Ms
ALS{"ALS"}
HTR2A -->|"associated with"| ALS
DISC1["DISC1"]
HTR2A -->|"associated with"| DISC1
FKBP5["FKBP5"]
HTR2A -->|"associated with"| FKBP5
NRG1["NRG1"]
HTR2A -->|"associated with"| NRG1
DAO["DAO"]
HTR2A -->|"associated with"| DAO
BMAL1["BMAL1"]
HTR2A -->|"associated with"| BMAL1
GRM4["GRM4"]
HTR2A -->|"associated with"| GRM4
HTTLPR["HTTLPR"]
HTTLPR -->|"associated with"| HTR2A
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
MITOCHONDRIAL_DNA -->|"associated with"| HTR2A
BDNF["BDNF"]
BDNF -->|"associated with"| HTR2A
PERIOD3["PERIOD3"]
PERIOD3 -->|"associated with"| HTR2A
BMAL1 -->|"associated with"| HTR2A
NCAM1["NCAM1"]
NCAM1 -->|"associated with"| HTR2A
DISC1 -->|"associated with"| HTR2A
G72["G72"]
G72 -->|"associated with"| HTR2A
NRG1 -->|"associated with"| HTR2A
MTDNA["MTDNA"]
MTDNA -->|"associated with"| HTR2A
DAO -->|"associated with"| HTR2A
TRPM2["TRPM2"]
TRPM2 -->|"associated with"| HTR2A
style HTR2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| ds-db4a006ea647 | provides_data_for | dataset | 1.00 |
| depression | associated_with | disease | 0.70 |
| Schizophrenia | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Bipolar | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| DISC1 | associated_with | gene | 0.60 |
| FKBP5 | associated_with | gene | 0.60 |
| NRG1 | associated_with | gene | 0.60 |
| DAO | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| GRM4 | associated_with | gene | 0.60 |
| SYNGR1 | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| NCAM1 | associated_with | gene | 0.60 |
| RGS4 | associated_with | gene | 0.60 |
| GRIN2B | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| TPH2 | associated_with | gene | 0.60 |
| GABRA5 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| TRPM2 | associated_with | gene | 0.60 |
| GRM3 | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| GRIK4 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| HTR2C | interacts_with | gene | 0.60 |
| SLC1A1 | interacts_with | gene | 0.60 |
| SLC6A2 | interacts_with | gene | 0.60 |
| SLC6A4 | translocates_to | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| Circadian Rhythm | associated_with | pathway | 0.60 |
| G72 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| ds-db4a006ea647 | data_in | dataset | 1.00 |
| BDNF | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| NCAM1 | associated_with | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| NRG1 | associated_with | gene | 0.60 |
| DAO | associated_with | gene | 0.60 |
| TRPM2 | associated_with | gene | 0.60 |
| GRM4 | associated_with | gene | 0.60 |
| GRM3 | associated_with | gene | 0.60 |
| GABRA5 | associated_with | gene | 0.60 |
| SYNGR1 | associated_with | gene | 0.60 |
| GRIN2B | associated_with | gene | 0.60 |
| RGS4 | associated_with | gene | 0.60 |
| TPH2 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| FKBP5 | associated_with | entity | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| GRIK4 | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| CACNA1H | interacts_with | gene | 0.60 |
| GABRB2 | interacts_with | gene | 0.60 |
| GRIA1 | interacts_with | gene | 0.60 |
| CYP2D6 | associated_with | gene | 0.60 |
| CYP2C19 | associated_with | gene | 0.60 |
| HTTLPR | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| PERIOD3 | associated_with | gene | 0.60 |
| G72 | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| CIRCADIAN RHYTHM | associated_with | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| PDLIM5 | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| ANXIETY | associated_with | gene | 0.60 |
| DRD2 | interacts_with | gene | 0.50 |
| HTR2C | interacts_with | gene | 0.50 |
| DRD1 | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||