gene

TPH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

146Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

TPH2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with ALS, Aging, Als. Connected to 99 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TPH2
Full Name	Tryptophan Hydroxylase 2
Chromosome	12q15
Protein Type	Enzyme
Function	Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin (5-hydroxytryptamine or 5-HT) in the central nervous system.
Primary Expression	peripheral tissues, TPH2 is specifically expressed in neuronal cells of the raphe nuclei and other brain regions
Pathways	Mapk, Oxidative Stress
UniProt ID	Q8IWU6
NCBI Gene ID	121556
Ensembl ID	ENSG00000139287
OMIM	607478
GeneCards	TPH2
Human Protein Atlas	TPH2
Taxonomy	ID
Associated Diseases	ALS, Bipolar, Depression, Ms, Multiple Sclerosis
Interactions	NGF, IDO1, GBA, TXNRD1, APP, BDNF
KG Connections	146 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TPH2 — AlphaFold Q8IWU6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TPH2["TPH2"]
    TPH2 -->|"inhibits"| Ms["Ms"]
    TPH2 -->|"inhibits"| Depression["Depression"]
    TPH2 -->|"inhibits"| Anxiety["Anxiety"]
    TPH2 -->|"activates"| Inflammation["Inflammation"]
    TPH2 -->|"activates"| Aging["Aging"]
    TPH2 -->|"activates"| Diabetes["Diabetes"]
    TPH2 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    TPH2 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    PANX1["PANX1"] -->|"regulates"| TPH2
    S100B["S100B"] -->|"regulates"| TPH2
    RELB["RELB"] -->|"regulates"| TPH2
    P2RY1["P2RY1"] -->|"regulates"| TPH2
    CASP3["CASP3"] -->|"regulates"| TPH2
    SOCS3["SOCS3"] -->|"regulates"| TPH2
    TRPA1["TRPA1"] -->|"regulates"| TPH2
    GENES["GENES"] -->|"regulates"| TPH2
    CXCL2["CXCL2"] -->|"regulates"| TPH2
    SNAP25["SNAP25"] -->|"regulates"| TPH2

Outgoing (72)

Target	Relation	Type	Str
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Depression	inhibits	disease	0.65
Anxiety	inhibits	disease	0.65
Inflammation	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Diabetes	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Depression	activates	disease	0.65
ALS	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
GABRA5	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
KCNK2	expressed_in	gene	0.60
CCL3	regulates	gene	0.60
NGF	activates	gene	0.60
IDO1	activates	gene	0.60
GBA	activates	gene	0.60
DRD1	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
DAO	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
MTNR1B	associated_with	gene	0.60
TXNRD1	activates	gene	0.60
APP	activates	gene	0.60
BDNF	activates	gene	0.60
BMAL1	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
Rb	associated_with	protein	0.60
neurodegeneration	associated_with	disease	0.60
Circadian Rhythm	associated_with	pathway	0.60
HO-1	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mapk	activates	pathway	0.60
GUT-BRAIN AXIS	activates	gene	0.60

Incoming (74)

Source	Relation	Type	Str
HTR2A	associated_with	gene	0.60
DISC1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
NRG1	associated_with	gene	0.60
DAO	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
GRM4	associated_with	gene	0.60
SYNGR1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
NCAM1	associated_with	gene	0.60
RGS4	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
TRPM2	associated_with	gene	0.60
GABRA5	associated_with	gene	0.60
GRM3	associated_with	gene	0.60
POLG	associated_with	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
NOS2	regulates	gene	0.60
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
SYT1	regulates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
P2RY2	regulates	gene	0.60
FOXP3	regulates	gene	0.60
SIRT3	activates	gene	0.60
TXNRD1	activates	gene	0.60
APP	activates	gene	0.60
TAU	activates	gene	0.60
TRKB	activates	gene	0.60
BDNF	activates	gene	0.60
NGF	activates	gene	0.60
MTNR1B	interacts_with	gene	0.60
SLC6A4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TPH2

Understanding Entity Pages

Summary

Wiki Pages (21)

Dorsal Raphe Nucleus Expanded (DRN)

Serotonergic Dysfunction in Neurodegeneration

Raphe Nucleus Serotonergic Neurons in Parkinson's Disease

Dorsal Raphe in Parkinson's Disease

Serotonin Signaling Pathway in Neurodegeneration

HPA Axis Neurons in Neurodegeneration

PSP Brainstem Degeneration

Cell Type Atlas

Amino Acid Supplementation in Parkinson's Disease

Rostral Ventromedial Medulla Neurons

Section 216: Advanced Pharmacogenomics and Precision Therapeutics for CBS/PSP

Serotonergic System in Neurodegeneration

Dorsal Raphe Nucleus Serotonergic

SLC6A4 Gene — Serotonin Transporter

Serotonin (5-Hydroxytryptamine, 5-HT)

raphe-nuclei-serotonin

medullary-rapth-magnus-pain

Serotonin Signaling Pathway

taar1-receptor-neurons