gene

RGS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RGS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

130Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

RGS4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, upregulates, implicated in. Associated with ALS, Als, Bipolar. Connected to 60 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolRGS4
Chromosome1q23.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionPrefrontal cortex, Striatum, Hippocampus
Molecular Weight24 kDa
Amino Acids206 aa
PathwaysAmyloid, Apoptosis, Oxidative Stress
UniProt IDP49798
NCBI Gene ID5999
Ensembl IDENSG00000117408
OMIM602514
GeneCardsRGS4
Human Protein AtlasRGS4
Symbol [@rgs2012] RGS4 [@rgs2018] [@rgs2016] [@rgs2017a] Full Name [@rgs2020] Regulator of G Protein Signaling 4 Chromosome1q23.3
Associated DiseasesALS, Bipolar, Depression, Ms, Schizophrenia
InteractionsNCAM1, DISC1, NRG1, GRM3, GRM4, SYNGR1
KG Connections130 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RGS4 — AlphaFold P49798 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

RGS4 Gene

gene · 874 words

TRA2B Protein - Transformer-2 Beta

protein · 4438 words

Dopamine Transporter (DAT) Dysfunction Pathway in Parkinson's Disease

mechanism · 2987 words

RNA Metabolism in Alzheimer's Disease

mechanism · 2071 words

GRM4 Gene

gene · 1868 words

Cerebellar Granule Cell Layer

cell · 836 words

Pathway Diagram

graph TD
    RGS4["<b>RGS4</b>"]
    TREM2["TREM2"]
    RGS4 -->|"upregulates"| TREM2
    MHC_I["MHC-I"]
    RGS4 -->|"upregulates"| MHC_I
    Schizophrenia{"Schizophrenia"}
    RGS4 -->|"associated with"| Schizophrenia
    Als{"Als"}
    RGS4 -->|"associated with"| Als
    Depression{"Depression"}
    RGS4 -->|"associated with"| Depression
    Bipolar{"Bipolar"}
    RGS4 -->|"associated with"| Bipolar
    Ms{"Ms"}
    RGS4 -->|"associated with"| Ms
    ALS{"ALS"}
    RGS4 -->|"associated with"| ALS
    GRIN2B["GRIN2B"]
    RGS4 -->|"associated with"| GRIN2B
    DRD1["DRD1"]
    RGS4 -->|"associated with"| DRD1
    TPH2["TPH2"]
    RGS4 -->|"associated with"| TPH2
    GABRA5["GABRA5"]
    RGS4 -->|"associated with"| GABRA5
    HTR2A["HTR2A"]
    HTR2A -->|"associated with"| RGS4
    DISC1["DISC1"]
    DISC1 -->|"associated with"| RGS4
    FKBP5["FKBP5"]
    FKBP5 -->|"associated with"| RGS4
    NRG1["NRG1"]
    NRG1 -->|"associated with"| RGS4
    DAO["DAO"]
    DAO -->|"associated with"| RGS4
    BMAL1["BMAL1"]
    BMAL1 -->|"associated with"| RGS4
    GRM4["GRM4"]
    GRM4 -->|"associated with"| RGS4
    SYNGR1["SYNGR1"]
    SYNGR1 -->|"associated with"| RGS4
    BDNF["BDNF"]
    BDNF -->|"associated with"| RGS4
    NCAM1["NCAM1"]
    NCAM1 -->|"associated with"| RGS4
    HTTLPR["HTTLPR"]
    HTTLPR -->|"associated with"| RGS4
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"associated with"| RGS4
    style RGS4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (79)

TargetRelationTypeStr
TREM2upregulatesgene0.80
MHC-Iupregulatesprotein0.80
Schizophreniaassociated_withdisease0.65
Alsassociated_withdisease0.65
Depressionassociated_withdisease0.65

Incoming (51)

SourceRelationTypeStr
HTR2Aassociated_withgene0.60
DISC1associated_withgene0.60
FKBP5associated_withgene0.60
NRG1associated_withgene0.60
DAOassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found