Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYNGR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SYNGR1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with ALS, Als, Bipolar. Connected to 51 entities in the SciDEX knowledge graph.
| Gene Symbol | SYNGR1 |
| Full Name | Synaptogyrin 1 |
| Chromosome | 22q12-q13 region |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| NCBI Gene ID | SYNGR1 Gene |
| Ensembl ID | ENSG00000185499 |
| OMIM | 603171 |
| GeneCards | SYNGR1 |
| Human Protein Atlas | SYNGR1 |
| Full name | Synaptogyrin 1 |
| Encoded protein | SYNGR1 Protein |
| Related pathways | Synaptic Vesicle Trafficking, Protein Aggregation |
| Associated Diseases | ALS, Bipolar, Depression, Ms, Schizophrenia |
| Interactions | GRIN2B, RGS4, NCAM1, DISC1, NRG1, GRM3 |
| KG Connections | 82 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
SYNGR1["<b>SYNGR1</b>"]
Schizophrenia{"Schizophrenia"}
SYNGR1 -->|"associated with"| Schizophrenia
Als{"Als"}
SYNGR1 -->|"associated with"| Als
Depression{"Depression"}
SYNGR1 -->|"associated with"| Depression
Bipolar{"Bipolar"}
SYNGR1 -->|"associated with"| Bipolar
Ms{"Ms"}
SYNGR1 -->|"associated with"| Ms
ALS{"ALS"}
SYNGR1 -->|"associated with"| ALS
BDNF["BDNF"]
SYNGR1 -->|"associated with"| BDNF
NCAM1["NCAM1"]
SYNGR1 -->|"associated with"| NCAM1
RGS4["RGS4"]
SYNGR1 -->|"associated with"| RGS4
GRIN2B["GRIN2B"]
SYNGR1 -->|"associated with"| GRIN2B
DRD1["DRD1"]
SYNGR1 -->|"associated with"| DRD1
TPH2["TPH2"]
SYNGR1 -->|"associated with"| TPH2
HTR2A["HTR2A"]
HTR2A -->|"associated with"| SYNGR1
DISC1["DISC1"]
DISC1 -->|"associated with"| SYNGR1
FKBP5["FKBP5"]
FKBP5 -->|"associated with"| SYNGR1
NRG1["NRG1"]
NRG1 -->|"associated with"| SYNGR1
DAO["DAO"]
DAO -->|"associated with"| SYNGR1
BMAL1["BMAL1"]
BMAL1 -->|"associated with"| SYNGR1
GRM4["GRM4"]
GRM4 -->|"associated with"| SYNGR1
HTTLPR["HTTLPR"]
HTTLPR -->|"associated with"| SYNGR1
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
MITOCHONDRIAL_DNA -->|"associated with"| SYNGR1
BDNF -->|"associated with"| SYNGR1
PERIOD3["PERIOD3"]
PERIOD3 -->|"associated with"| SYNGR1
G72["G72"]
G72 -->|"associated with"| SYNGR1
style SYNGR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Schizophrenia | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Bipolar | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| BDNF | associated_with | gene | 0.60 |
| NCAM1 | associated_with | gene | 0.60 |
| RGS4 | associated_with | gene | 0.60 |
| GRIN2B | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| TPH2 | associated_with | gene | 0.60 |
| GABRA5 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| TRPM2 | associated_with | gene | 0.60 |
| GRM3 | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| FKBP5 | associated_with | gene | 0.60 |
| DAO | associated_with | gene | 0.60 |
| NRG1 | associated_with | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| GRM4 | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| schizophrenia | interacts_with | disease | 0.60 |
| Circadian Rhythm | associated_with | pathway | 0.60 |
| PDLIM5 | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| CIRCADIAN RHYTHM | associated_with | gene | 0.60 |
| G72 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| PERIOD3 | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| HTTLPR | associated_with | gene | 0.60 |
| App | associated_with | protein | 0.60 |
| GRIN2B | interacts_with | gene | 0.50 |
| TPH2 | co_expressed_with | gene | 0.50 |
| TRPM2 | co_expressed_with | gene | 0.50 |
| Bipolar | interacts_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HTR2A | associated_with | gene | 0.60 |
| DISC1 | associated_with | gene | 0.60 |
| FKBP5 | associated_with | gene | 0.60 |
| NRG1 | associated_with | gene | 0.60 |
| DAO | associated_with | gene | 0.60 |
| BMAL1 | associated_with | gene | 0.60 |
| GRM4 | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| TRPM2 | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| GABRA5 | associated_with | gene | 0.60 |
| GRM3 | associated_with | gene | 0.60 |
| GRIN2B | associated_with | gene | 0.60 |
| RGS4 | associated_with | gene | 0.60 |
| NCAM1 | associated_with | gene | 0.60 |
| POLG | associated_with | gene | 0.60 |
| TPH2 | associated_with | gene | 0.60 |
| DAO | interacts_with | gene | 0.60 |
| GRIN2B | interacts_with | gene | 0.60 |
| HTTLPR | associated_with | gene | 0.60 |
| MITOCHONDRIAL DNA | associated_with | gene | 0.60 |
| PERIOD3 | associated_with | gene | 0.60 |
| G72 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| PDLIM5 | associated_with | gene | 0.60 |
| MTDNA | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| CIRCADIAN RHYTHM | associated_with | gene | 0.60 |
| SCHIZOPHRENIA | associated_with | entity | 0.60 |
| AND | associated_with | gene | 0.60 |
| G72 | interacts_with | gene | 0.60 |
| RGS4 | interacts_with | gene | 0.50 |
| NCAM1 | interacts_with | gene | 0.50 |
| DISC1 | interacts_with | gene | 0.50 |
| NRG1 | interacts_with | gene | 0.50 |
| GRM3 | interacts_with | gene | 0.50 |
| GRM4 | interacts_with | gene | 0.50 |
| POLG | co_expressed_with | gene | 0.50 |
| RGS4 | co_expressed_with | gene | 0.50 |
| SCHIZOPHRENIA | interacts_with | disease | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||