gene

IGF2BP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF2BP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections
0Hypotheses
0Analyses
24Outgoing
16Incoming

Summary

IGF2BP3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, therapeutic target, implicated in. Associated with Cancer, Ovarian Cancer. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolIGF2BP3
Full Nameigf2bp3
Chromosome7p11
Protein TypeGene
Functionis a member of the VICKZ family of RNA-binding proteins.
Molecular Weight64 kDa
Amino Acids579 aa
Exons17
PathwaysAutophagy
NCBI Gene IDSearch NCBI
GeneCardsIGF2BP3
Human Protein AtlasIGF2BP3
Associated Diseasesneurodegeneration
InteractionsAKT, EGFR, MTOR, HDAC2, SENP1, Sumo
KG Connections40 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

IGF2BP3 — Insulin-Like Growth Factor 2 mRNA-Binding Protein 3

gene · 1772 words

igf2bp3-protein

protein · 1649 words

IGF2BP2

gene · 1616 words

IGF2BP1 Protein

protein · 1584 words

IGF2BP2 Protein

protein · 1013 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    IGF2BP3["<b>IGF2BP3</b>"]
    ESM1(["ESM1"])
    IGF2BP3 -->|"regulates"| ESM1
    Ovarian_Cancer{"Ovarian Cancer"}
    IGF2BP3 -->|"therapeutic_target"| Ovarian_Cancer
    Cancer{"Cancer"}
    IGF2BP3 -->|"therapeutic_target"| Cancer
    Autophagy["Autophagy"]
    IGF2BP3 -->|"regulates"| Autophagy
    Cholesterol["Cholesterol"]
    IGF2BP3 -->|"associated_with"| Cholesterol
    Lipid_Metabolism["Lipid Metabolism"]
    IGF2BP3 -->|"therapeutic_target"| Lipid_Metabolism
    BECN1(["BECN1"])
    BECN1 -->|"therapeutic_target"| IGF2BP3
    HMGCR(["HMGCR"])
    HMGCR -->|"regulates"| IGF2BP3
    CANCER(["CANCER"])
    CANCER -->|"therapeutic_target"| IGF2BP3
    GENES(["GENES"])
    GENES -->|"regulates"| IGF2BP3
    style IGF2BP3 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (24)

TargetRelationTypeStr
ESM1regulatesprotein0.90
Ovarian Cancertherapeutic_targetdisease0.65
Cancertherapeutic_targetdisease0.65
Tumoractivatesdisease0.65
Leukemiaactivatesdisease0.65

Incoming (16)

SourceRelationTypeStr
BECN1therapeutic_targetgene0.60
HMGCRregulatesgene0.60
HSPA5regulatesgene0.60
RANKregulatesgene0.60
HDAC2activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found