Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IGF2BP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IGF2BP3 is a gene implicated in neurodegeneration research. Key relationships include: regulates, therapeutic target, implicated in. Associated with Cancer, Ovarian Cancer. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | IGF2BP3 |
| Full Name | igf2bp3 |
| Chromosome | 7p11 |
| Protein Type | Gene |
| Function | is a member of the VICKZ family of RNA-binding proteins. |
| Molecular Weight | 64 kDa |
| Amino Acids | 579 aa |
| Exons | 17 |
| Pathways | Autophagy |
| NCBI Gene ID | Search NCBI |
| GeneCards | IGF2BP3 |
| Human Protein Atlas | IGF2BP3 |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, EGFR, MTOR, HDAC2, SENP1, Sumo |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
IGF2BP3["<b>IGF2BP3</b>"]
ESM1(["ESM1"])
IGF2BP3 -->|"regulates"| ESM1
Ovarian_Cancer{"Ovarian Cancer"}
IGF2BP3 -->|"therapeutic_target"| Ovarian_Cancer
Cancer{"Cancer"}
IGF2BP3 -->|"therapeutic_target"| Cancer
Autophagy["Autophagy"]
IGF2BP3 -->|"regulates"| Autophagy
Cholesterol["Cholesterol"]
IGF2BP3 -->|"associated_with"| Cholesterol
Lipid_Metabolism["Lipid Metabolism"]
IGF2BP3 -->|"therapeutic_target"| Lipid_Metabolism
BECN1(["BECN1"])
BECN1 -->|"therapeutic_target"| IGF2BP3
HMGCR(["HMGCR"])
HMGCR -->|"regulates"| IGF2BP3
CANCER(["CANCER"])
CANCER -->|"therapeutic_target"| IGF2BP3
GENES(["GENES"])
GENES -->|"regulates"| IGF2BP3
style IGF2BP3 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| ESM1 | regulates | protein | 0.90 |
| Ovarian Cancer | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Leukemia | activates | disease | 0.65 |
| AKT | activates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| HDAC2 | activates | gene | 0.60 |
| SENP1 | activates | gene | 0.60 |
| Sumo | activates | protein | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Cholesterol | associated_with | pathway | 0.60 |
| Lipid Metabolism | therapeutic_target | pathway | 0.60 |
| Mtor | activates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| RNA | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| Egfr | activates | protein | 0.60 |
| Igf | activates | protein | 0.60 |
| Ras | activates | protein | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BECN1 | therapeutic_target | gene | 0.60 |
| HMGCR | regulates | gene | 0.60 |
| HSPA5 | regulates | gene | 0.60 |
| RANK | regulates | gene | 0.60 |
| HDAC2 | activates | gene | 0.60 |
| SENP1 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| ESM1 | regulates | gene | 0.60 |
| BECN1 | regulates | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||