concept

IL-1BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-1BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

4Analyses

38Outgoing

19Incoming

0Experiments

5Debates

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💡 Concept Info

Name	IL-1BETA
Key Genes/Proteins	App, BAX, BCL2, CASP3, CYTOKINES, FADD
Related Diseases	Als, ALS, Inflammation

Pathway Diagram

graph TD
    IL_1BETA["IL-1BETA"]
    IL_1BETA -->|"activates"| Neurodegeneration["Neurodegeneration"]
    IL_1BETA -->|"activates"| Als["Als"]
    IL_1BETA -->|"activates"| Parkinson["Parkinson"]
    IL_1BETA -->|"activates"| Neuroinflammation["Neuroinflammation"]
    IL_1BETA -->|"activates"| Tumor["Tumor"]
    IL_1BETA -->|"activates"| ALS["ALS"]
    IL_1BETA -->|"activates"| Inflammation["Inflammation"]
    IL_1BETA -->|"activates"| PARKINSON["PARKINSON"]
    MICROGLIA["MICROGLIA"] -->|"activates"| IL_1BETA
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| IL_1BETA
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| IL_1BETA
    PARKINSON -->|"activates"| IL_1BETA
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| IL_1BETA
    CYTOKINES["CYTOKINES"] -->|"activates"| IL_1BETA
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| IL_1BETA
    BCL2["BCL2"] -->|"regulates"| IL_1BETA

Outgoing (38)

Target	Relation	Type	Str
Tau Hyperphosphorylation	causes	phenotype	0.70
synapse loss	causes	phenotype	0.70
neurodegeneration in PD	causes	mechanism	0.70
neuroinflammation	causes	mechanism	0.70
Inflammation	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Neuron	activates	cell_type	0.60
TNF	associated_with	gene	0.60
Microglia	activates	cell_type	0.60
PARKINSON	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
Il-1	associated_with	protein	0.60
App	associated_with	protein	0.60
Microglia	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Substantia Nigra	expressed_in	brain_region	0.55
MICROGLIA	activates	cell_type	0.50
IL6	regulates	gene	0.45
SQSTM1	regulates	gene	0.45
TNF	regulates	gene	0.35
TNF	expressed_in	gene	0.35
IL-6	expressed_in	gene	0.35
TNF	activates	gene	0.35
NEUROGENESIS	activates	process	0.30
IL6	activates	gene	0.30
TNF	protects_against	gene	0.30
NF-KB	regulates	gene	0.30
TP53	regulates	gene	0.30
INFLAMMATION	regulates	process	0.30
OXIDATIVE STRESS	regulates	process	0.30
IL6	therapeutic_target	gene	0.30

Incoming (19)

Source	Relation	Type	Str
NLRP3 Inflammasome	activates	gene	0.90
ABETA	upregulates	protein	0.80
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
TNF	associated_with	gene	0.60
MICROGLIA	activates	gene	0.60
APOPTOSIS	regulates	process	0.45
CYTOKINES	activates	protein	0.35
BCL2	regulates	gene	0.30
APOPTOSIS	activates	process	0.30
APOPTOSIS	protects_against	process	0.30
CYTOKINES	protects_against	protein	0.30
CASP3	protects_against	gene	0.30
BCL2	protects_against	gene	0.30
BAX	protects_against	gene	0.30
CYTOKINES	regulates	protein	0.30
FADD	regulates	gene	0.30
AUTOPHAGY	regulates	process	0.30