MIEF2

Understanding Entity Pages

This page aggregates everything SciDEX knows about MIEF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MIEF2 encodes MiD50, a mitochondrial outer membrane protein that recruits Drp1 to regulate mitochondrial fission. Dysfunction contributes to Parkinson's disease, Alzheimer's disease, and other neurodegenerative conditions through impaired mitochondrial dynamics and mitophagy.

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graph TD
    MIEF2["MIEF2"]
    Obesity{"Obesity"}
    MIEF2 -->|"regulates"| Obesity
    Cancer{"Cancer"}
    MIEF2 -->|"regulates"| Cancer
    Diabetes{"Diabetes"}
    MIEF2 -->|"regulates"| Diabetes
    Cardiovascular{"Cardiovascular"}
    MIEF2 -->|"regulates"| Cardiovascular
    Ms{"Ms"}
    MIEF2 -->|"regulates"| Ms
    PINK1["PINK1"]
    MIEF2 -->|"regulates"| PINK1
    CANCER["CANCER"]
    MIEF2 -->|"regulates"| CANCER
    AND["AND"]
    MIEF2 -->|"regulates"| AND
    FXN["FXN"]
    MIEF2 -->|"regulates"| FXN
    MITOPHAGY["MITOPHAGY"]
    MIEF2 -->|"regulates"| MITOPHAGY
    AUTOPHAGY["AUTOPHAGY"]
    MIEF2 -->|"regulates"| AUTOPHAGY
    MITOCHONDRIA["MITOCHONDRIA"]
    MIEF2 -->|"regulates"| MITOCHONDRIA
    C_MYC["C-MYC"]
    MIEF2 -->|"regulates"| C_MYC
    MFN1["MFN1"]
    MIEF2 -->|"regulates"| MFN1
    FIS1["FIS1"]
    MIEF2 -->|"regulates"| FIS1