gene

PIK3R3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3R3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections

0Hypotheses

0Analyses

36Outgoing

16Incoming

0Experiments

0Debates

Summary

Phosphoinositide-3-Kinase Regulatory Subunit 3 (p55γ) - brain-enriched PI3K regulatory subunit involved in neuronal signaling, synaptic plasticity, and neurodegeneration

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🧬 Gene Info

Gene Symbol	PIK3R3
Full Name	Phosphoinositide-3-Kinase Regulatory Subunit 3
Aliases	Phosphoinositide-3-Kinase Regulatory Subunit 3 (p55γ)
Chromosome	1p36.22
Function	encodes a protein with distinct structural features that differentiate it from other PI3K regulatory subunits.
Primary Expression	Brain (highest), immune cells, various tissues
Molecular Weight	55 kDa
Amino Acids	461 aa
Exons	13 coding exons
Pathways	PI3K
UniProt ID	Q99836
NCBI Gene ID	5293
Ensembl ID	ENSG00000117477
OMIM	606954
GeneCards	PIK3R3
Human Protein Atlas	PIK3R3
Associated Diseases	neurodegeneration
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, ARC, CANCER, NESTIN
KG Connections	52 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PIK3R3 — AlphaFold Q99836 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PIK3R3 Gene

gene · 1740 words

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Pathway Diagram

graph TD
    PIK3R3["<b>PIK3R3</b>"]
    Alzheimer{"Alzheimer"}
    PIK3R3 -->|"interacts with"| Alzheimer
    Als{"Als"}
    PIK3R3 -->|"interacts with"| Als
    Ms{"Ms"}
    PIK3R3 -->|"interacts with"| Ms
    Carcinoma{"Carcinoma"}
    PIK3R3 -->|"regulates"| Carcinoma
    Cancer{"Cancer"}
    PIK3R3 -->|"activates"| Cancer
    Tumor{"Tumor"}
    PIK3R3 -->|"regulates"| Tumor
    PIK3R3 -->|"therapeutic target"| Carcinoma
    PIK3R3 -->|"therapeutic target"| Cancer
    PIK3R3 -->|"therapeutic target"| Tumor
    AKT["AKT"]
    PIK3R3 -->|"interacts with"| AKT
    PI3K["PI3K"]
    PIK3R3 -->|"activates"| PI3K
    ARC["ARC"]
    PIK3R3 -->|"activates"| ARC
    NESTIN["NESTIN"]
    NESTIN -->|"interacts with"| PIK3R3
    VHL["VHL"]
    VHL -->|"regulates"| PIK3R3
    PI3K -->|"inhibits"| PIK3R3
    AKT -->|"inhibits"| PIK3R3
    PIK3CA["PIK3CA"]
    PIK3CA -->|"therapeutic target"| PIK3R3
    MTOR["MTOR"]
    MTOR -->|"therapeutic target"| PIK3R3
    PIK3CD["PIK3CD"]
    PIK3CD -->|"therapeutic target"| PIK3R3
    MIRNAS["MIRNAS"]
    MIRNAS -->|"therapeutic target"| PIK3R3
    PI3K -->|"therapeutic target"| PIK3R3
    AKT -->|"therapeutic target"| PIK3R3
    AKT -->|"interacts with"| PIK3R3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"interacts with"| PIK3R3
    style PIK3R3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (36)

Target	Relation	Type	Str
Tumor	regulates	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	regulates	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Mtor	therapeutic_target	pathway	0.60
CANCER	therapeutic_target	gene	0.60
Pi3K	therapeutic_target	pathway	0.60
MICRORNAS	therapeutic_target	gene	0.60
Akt	therapeutic_target	pathway	0.60
AKT	interacts_with	gene	0.60
PI3K	activates	gene	0.60
ARC	activates	gene	0.60
PI3K	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
PIK3CD	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
AKT3	therapeutic_target	gene	0.60
PIK3CB	therapeutic_target	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
METTL3	regulates	gene	0.60
Akt	inhibits	pathway	0.60
Pi3K	inhibits	pathway	0.60
AND	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
Mtor	interacts_with	pathway	0.60
Pi3K	activates	pathway	0.60
Synaptic Plasticity	interacts_with	pathway	0.60
Akt	interacts_with	pathway	0.60
CANCER	activates	gene	0.60

Incoming (16)

Source	Relation	Type	Str
NESTIN	interacts_with	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
PIK3CD	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
VHL	regulates	gene	0.60
PI3K	inhibits	gene	0.60
AKT	inhibits	gene	0.60
AKT	interacts_with	gene	0.60
ARC	activates	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
SYNAPSE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity