Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PSMA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PSMA1 |
| Full Name | Proteasome 20S Subunit Alpha 1 |
| Chromosome | 11p15.2 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 27.6 kDa |
| Amino Acids | 263 aa |
| NCBI Gene ID | 5682 |
| Ensembl ID | ENSG00000129084 |
| GeneCards | PSMA1 |
| Human Protein Atlas | PSMA1 |
| Protein Product | PSMA1 Protein |
| Complex Membership | 20S/26S ubiquitin-proteasome system |
| Major Disease Context | Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington's Disease |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | PSMB5, RPS6KB1, SQSTM1, TP53, SMAD, TGFB |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["PSMA1"]
N1["AKT"]
N1 -->|"activates"| N0
N2["PSMB5"]
N0 -->|"activates"| N2
N3["RPS6KB1"]
N0 -->|"activates"| N3
N4["SMAD"]
N0 -->|"activates"| N4
N5["SQSTM1"]
N0 -->|"activates"| N5
N6["TGFB"]
N0 -->|"activates"| N6
N7["TP53"]
N0 -->|"activates"| N7
N8["Alzheimer's disease"]
N0 -->|"activates"| N8
N9["Parkinson's disease"]
N0 -->|"activates"| N9
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
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classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
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classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
class N0 protein
class N1 gene
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 disease
class N9 disease| Target | Relation | Type | Str |
|---|---|---|---|
| PSMB5 | activates | gene | 0.60 |
| RPS6KB1 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| TP53 | activates | gene | 0.60 |
| SMAD | activates | gene | 0.60 |
| TGFB | activates | gene | 0.60 |
| Alzheimer's disease | activates | disease | 0.60 |
| Parkinson's disease | activates | disease | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| senescence | participates_in | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| ROS | activates | gene | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AKT | activates | gene | 0.60 |
| CDKN1A | activates | gene | 0.60 |
| CDKN2A | activates | gene | 0.60 |
| EIF4EBP1 | activates | gene | 0.60 |
| GLB1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MKI67 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| PIK3CA | activates | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| DMSO | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| PCNA | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||