protein

PSMA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections
0Hypotheses
0Analyses
15Outgoing
15Incoming

Summary

Page for PSMA1 Protein

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🔬 Protein Info
Gene SymbolPSMA1
Full NameProteasome 20S Subunit Alpha 1
Chromosome11p15.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight27.6 kDa
Amino Acids263 aa
NCBI Gene ID5682
Ensembl IDENSG00000129084
GeneCardsPSMA1
Human Protein AtlasPSMA1
Protein ProductPSMA1 Protein
Complex Membership20S/26S ubiquitin-proteasome system
Major Disease ContextAlzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), Huntington's Disease
Associated Diseasesneurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsPSMB5, RPS6KB1, SQSTM1, TP53, SMAD, TGFB
KG Connections30 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

PSMA1 Gene

gene · 983 words

proteasome-ubiquitin-system-dysfunction-parkinsons

general · 3977 words

Reactive Oxygen Species (ROS) Pathway

mechanism · 3211 words

Proteasomal Pathway in Neurodegeneration

mechanism · 1803 words

UBQLN4 Gene

gene · 1719 words

NRF2 — Nuclear Factor Erythroid 2-Related Factor 2

protein · 1453 words

Pathway Diagram

flowchart TD
    N0["PSMA1"]
    N1["AKT"]
    N1 -->|"activates"| N0
    N2["PSMB5"]
    N0 -->|"activates"| N2
    N3["RPS6KB1"]
    N0 -->|"activates"| N3
    N4["SMAD"]
    N0 -->|"activates"| N4
    N5["SQSTM1"]
    N0 -->|"activates"| N5
    N6["TGFB"]
    N0 -->|"activates"| N6
    N7["TP53"]
    N0 -->|"activates"| N7
    N8["Alzheimer's disease"]
    N0 -->|"activates"| N8
    N9["Parkinson's disease"]
    N0 -->|"activates"| N9

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
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    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 protein
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 disease
    class N9 disease

Outgoing (15)

TargetRelationTypeStr
PSMB5activatesgene0.60
RPS6KB1activatesgene0.60
SQSTM1activatesgene0.60
TP53activatesgene0.60
SMADactivatesgene0.60

Incoming (15)

SourceRelationTypeStr
AKTactivatesgene0.60
CDKN1Aactivatesgene0.60
CDKN2Aactivatesgene0.60
EIF4EBP1activatesgene0.60
GLB1activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found