Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB32: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB32 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, contributes to. Associated with Als, Glioblastoma, Ms. Connected to 29 entities in the SciDEX knowledge graph.
| Gene Symbol | RAB32 |
| Full Name | RAB32, Member RAS Oncogene Family |
| Chromosome | 6q16.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 25 kDa |
| Amino Acids | 225 aa |
| UniProt ID | [Q9NX93](https://www.uniprot.org/uniprot/Q9NX93) |
| Ensembl ID | ENSG00000116574 |
| OMIM | 613735 |
| GeneCards | RAB32 |
| Human Protein Atlas | RAB32 |
| GTP-binding domain | The core domain that binds GTP/GDP and mediates switching between active and inactive states |
| Switch I region | Undergoes conformational changes upon GTP binding, mediating effector interactions |
| Switch II region | Critical for GTP hydrolysis and effector binding |
| Hypervariable C-terminal region | Contains cysteine residues for geranylgeranylation and membrane anchoring |
| Associated Diseases | Als, Ms, Parkinson, Parkinson's disease, Tumor |
| Interactions | LRRK2 |
| KG Connections | 59 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB32["<b>RAB32</b>"]
Ms{"Ms"}
RAB32 -->|"contributes to"| Ms
Glioblastoma{"Glioblastoma"}
RAB32 -->|"regulates"| Glioblastoma
Tumor{"Tumor"}
RAB32 -->|"associated with"| Tumor
Als{"Als"}
RAB32 -->|"associated with"| Als
RAB32 -->|"associated with"| Ms
Parkinson{"Parkinson"}
RAB32 -->|"regulates"| Parkinson
RAB32 -->|"regulates"| Als
RAB32 -->|"associated with"| Parkinson
DRP1["DRP1"]
RAB32 -->|"regulates"| DRP1
GBM["GBM"]
RAB32 -->|"associated with"| GBM
MMP9["MMP9"]
RAB32 -->|"associated with"| MMP9
MMP2["MMP2"]
RAB32 -->|"associated with"| MMP2
ERK["ERK"]
ERK -->|"regulates"| RAB32
RAS["RAS"]
RAS -->|"contributes to"| RAB32
GBM -->|"associated with"| RAB32
DRP1 -->|"regulates"| RAB32
MMP9 -->|"associated with"| RAB32
MMP2 -->|"associated with"| RAB32
style RAB32 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.75 |
| Ms | contributes_to | disease | 0.65 |
| Glioblastoma | regulates | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Tumor | contributes_to | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| DRP1 | regulates | gene | 0.60 |
| GBM | associated_with | gene | 0.60 |
| MMP9 | associated_with | gene | 0.60 |
| MMP2 | associated_with | gene | 0.60 |
| DRP1 | associated_with | gene | 0.60 |
| LRRK2 | activates | gene | 0.60 |
| VIMENTIN | associated_with | gene | 0.60 |
| OPTN | regulates | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| SNCA | causes | gene | 0.60 |
| VPS35 | causes | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| SPG7 | associated_with | gene | 0.60 |
| VCP | associated_with | gene | 0.60 |
| ERK | regulates | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| GLIOBLASTOMA | regulates | gene | 0.60 |
| Invasion | contributes_to | pathway | 0.60 |
| App | regulates | protein | 0.60 |
| Parkinson's disease | associated_with | disease | 0.60 |
| Parkinson's disease | regulates | disease | 0.60 |
| Parkinson's disease | interacts_with | disease | 0.60 |
| Parkinson's disease | activates | disease | 0.60 |
| Parkinson's disease | causes | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GBM | associated_with | gene | 0.60 |
| DRP1 | regulates | gene | 0.60 |
| MMP9 | associated_with | gene | 0.60 |
| MMP2 | associated_with | gene | 0.60 |
| LRRK2 | activates | gene | 0.60 |
| CHCHD2 | causes | gene | 0.60 |
| GBA1 | causes | gene | 0.60 |
| LRRK2 | causes | gene | 0.60 |
| PARK7 | causes | gene | 0.60 |
| PINK1 | causes | gene | 0.60 |
| PRKN | causes | gene | 0.60 |
| ATXN2 | associated_with | gene | 0.60 |
| GCH1 | associated_with | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| PLA2G6 | associated_with | gene | 0.60 |
| PNPLA6 | associated_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| ERK | regulates | gene | 0.60 |
| RAS | contributes_to | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| MITOCHONDRIA | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||