gene

RAB32

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB32: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections
0Hypotheses
0Analyses
35Outgoing
24Incoming

Summary

RAB32 is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, contributes to. Associated with Als, Glioblastoma, Ms. Connected to 29 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRAB32
Full NameRAB32, Member RAS Oncogene Family
Chromosome6q16.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight25 kDa
Amino Acids225 aa
UniProt ID[Q9NX93](https://www.uniprot.org/uniprot/Q9NX93)
Ensembl IDENSG00000116574
OMIM613735
GeneCardsRAB32
Human Protein AtlasRAB32
GTP-binding domainThe core domain that binds GTP/GDP and mediates switching between active and inactive states
Switch I regionUndergoes conformational changes upon GTP binding, mediating effector interactions
Switch II regionCritical for GTP hydrolysis and effector binding
Hypervariable C-terminal regionContains cysteine residues for geranylgeranylation and membrane anchoring
Associated DiseasesAls, Ms, Parkinson, Parkinson's disease, Tumor
InteractionsLRRK2
KG Connections59 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

RAB32 Gene

gene · 1731 words

RAB9A

gene · 3229 words

Endosomal Trafficking Pathway

mechanism · 3217 words

VPS35/Retromer Pathway in Parkinson's Disease

mechanism · 2946 words

LRRK2 Signaling Pathway in Parkinson's Disease

mechanism · 2314 words

LYST Gene — Lysosomal Trafficking Regulator

gene · 1994 words

Pathway Diagram

graph TD
    RAB32["<b>RAB32</b>"]
    Ms{"Ms"}
    RAB32 -->|"contributes to"| Ms
    Glioblastoma{"Glioblastoma"}
    RAB32 -->|"regulates"| Glioblastoma
    Tumor{"Tumor"}
    RAB32 -->|"associated with"| Tumor
    Als{"Als"}
    RAB32 -->|"associated with"| Als
    RAB32 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    RAB32 -->|"regulates"| Parkinson
    RAB32 -->|"regulates"| Als
    RAB32 -->|"associated with"| Parkinson
    DRP1["DRP1"]
    RAB32 -->|"regulates"| DRP1
    GBM["GBM"]
    RAB32 -->|"associated with"| GBM
    MMP9["MMP9"]
    RAB32 -->|"associated with"| MMP9
    MMP2["MMP2"]
    RAB32 -->|"associated with"| MMP2
    ERK["ERK"]
    ERK -->|"regulates"| RAB32
    RAS["RAS"]
    RAS -->|"contributes to"| RAB32
    GBM -->|"associated with"| RAB32
    DRP1 -->|"regulates"| RAB32
    MMP9 -->|"associated with"| RAB32
    MMP2 -->|"associated with"| RAB32
    style RAB32 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (35)

TargetRelationTypeStr
Alsassociated_withdisease0.75
Mscontributes_todisease0.65
Glioblastomaregulatesdisease0.65
Tumorassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (24)

SourceRelationTypeStr
GBMassociated_withgene0.60
DRP1regulatesgene0.60
MMP9associated_withgene0.60
MMP2associated_withgene0.60
LRRK2activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found