gene

RIN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RIN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

52Connections
0Hypotheses
0Analyses
10Outgoing
42Incoming

Summary

RIN3 encodes a Rho GTPase-activating protein involved in endocytic trafficking and synaptic function. Variants are associated with Parkinson's disease risk.

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🧬 Gene Info
Gene SymbolRIN3
Full NameRho GTPase-activating protein 25
Chromosome14q32.12
Protein FamilyRho GTPase-activating proteins
Functionencodes a Rho GTPase-activating protein that specifically regulates Rho family small GTPases, particularly Rac1 and Cdc42.
Primary Expressiondopaminergic neurons
Subcellular LocalizationRIN3 shows distinct localization patterns:
Amino Acids922 aa
Gene TypeProtein-coding
UniProt IDQ8WU66
NCBI Gene ID154796
Ensembl IDENSG00000155097
OMIM614086
GeneCardsRIN3
Human Protein AtlasRIN3
Associated DiseasesAls, Alzheimer, Ms
InteractionsSLC24A4, SORL1, ZCWPW1, ABCA7, BIN1, CASS4
KG Connections52 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RIN3 — AlphaFold Q8WU66 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

RIN3 — Rho GTPase-Activating Protein 25

gene · 1345 words

BIN1 — Bridging Integrator 1

gene · 3043 words

SORL1 Protein

protein · 2914 words

amyloid-hypothesis

mechanism · 2274 words

BIN1→Endosomal Dysfunction→Tau Pathology→AD Causal Chain

mechanism · 1896 words

RAB5C Protein

protein · 1396 words

Pathway Diagram

graph TD
    RIN3["RIN3"]
    Ms{"Ms"}
    RIN3 -->|"associated_with"| Ms
    Als{"Als"}
    RIN3 -->|"associated_with"| Als
    Alzheimer{"Alzheimer"}
    RIN3 -->|"associated_with"| Alzheimer
    ZCWPW1["ZCWPW1"]
    RIN3 -->|"associated_with"| ZCWPW1
    PLD3["PLD3"]
    PLD3 -->|"associated_with"| RIN3
    ABCA7["ABCA7"]
    ABCA7 -->|"associated_with"| RIN3
    SORL1["SORL1"]
    SORL1 -->|"associated_with"| RIN3
    PICALM["PICALM"]
    PICALM -->|"associated_with"| RIN3
    CR1["CR1"]
    CR1 -->|"associated_with"| RIN3
    TREM2["TREM2"]
    TREM2 -->|"associated_with"| RIN3
    CASS4["CASS4"]
    CASS4 -->|"associated_with"| RIN3
    CD33["CD33"]
    CD33 -->|"associated_with"| RIN3
    NME8["NME8"]
    NME8 -->|"associated_with"| RIN3
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated_with"| RIN3
    BIN1["BIN1"]
    BIN1 -->|"associated_with"| RIN3

Outgoing (10)

TargetRelationTypeStr
Msassociated_withdisease0.65
Alsassociated_withdisease0.65
Alzheimerassociated_withdisease0.65
ZCWPW1associated_withgene0.60
SLC24A4interacts_withgene0.60

Incoming (42)

SourceRelationTypeStr
PLD3associated_withgene0.60
ABCA7associated_withgene0.60
SORL1associated_withgene0.60
PICALMassociated_withgene0.60
CR1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found