Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RIN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RIN3 encodes a Rho GTPase-activating protein involved in endocytic trafficking and synaptic function. Variants are associated with Parkinson's disease risk.
| Gene Symbol | RIN3 |
| Full Name | Rho GTPase-activating protein 25 |
| Chromosome | 14q32.12 |
| Protein Family | Rho GTPase-activating proteins |
| Function | encodes a Rho GTPase-activating protein that specifically regulates Rho family small GTPases, particularly Rac1 and Cdc42. |
| Primary Expression | dopaminergic neurons |
| Subcellular Localization | RIN3 shows distinct localization patterns: |
| Amino Acids | 922 aa |
| Gene Type | Protein-coding |
| UniProt ID | Q8WU66 |
| NCBI Gene ID | 154796 |
| Ensembl ID | ENSG00000155097 |
| OMIM | 614086 |
| GeneCards | RIN3 |
| Human Protein Atlas | RIN3 |
| Associated Diseases | Als, Alzheimer, Ms |
| Interactions | SLC24A4, SORL1, ZCWPW1, ABCA7, BIN1, CASS4 |
| KG Connections | 52 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RIN3["RIN3"]
Ms{"Ms"}
RIN3 -->|"associated_with"| Ms
Als{"Als"}
RIN3 -->|"associated_with"| Als
Alzheimer{"Alzheimer"}
RIN3 -->|"associated_with"| Alzheimer
ZCWPW1["ZCWPW1"]
RIN3 -->|"associated_with"| ZCWPW1
PLD3["PLD3"]
PLD3 -->|"associated_with"| RIN3
ABCA7["ABCA7"]
ABCA7 -->|"associated_with"| RIN3
SORL1["SORL1"]
SORL1 -->|"associated_with"| RIN3
PICALM["PICALM"]
PICALM -->|"associated_with"| RIN3
CR1["CR1"]
CR1 -->|"associated_with"| RIN3
TREM2["TREM2"]
TREM2 -->|"associated_with"| RIN3
CASS4["CASS4"]
CASS4 -->|"associated_with"| RIN3
CD33["CD33"]
CD33 -->|"associated_with"| RIN3
NME8["NME8"]
NME8 -->|"associated_with"| RIN3
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"associated_with"| RIN3
BIN1["BIN1"]
BIN1 -->|"associated_with"| RIN3| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| ZCWPW1 | associated_with | gene | 0.60 |
| SLC24A4 | interacts_with | gene | 0.60 |
| SORL1 | interacts_with | gene | 0.60 |
| ZCWPW1 | interacts_with | gene | 0.60 |
| SORL1 | associated_with | gene | 0.60 |
| SPI1 | associated_with | gene | 0.60 |
| TREM2 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PLD3 | associated_with | gene | 0.60 |
| ABCA7 | associated_with | gene | 0.60 |
| SORL1 | associated_with | gene | 0.60 |
| PICALM | associated_with | gene | 0.60 |
| CR1 | associated_with | gene | 0.60 |
| TREM2 | associated_with | gene | 0.60 |
| CASS4 | associated_with | gene | 0.60 |
| CD33 | associated_with | gene | 0.60 |
| NME8 | associated_with | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| CD2AP | associated_with | gene | 0.60 |
| INPP5D | associated_with | gene | 0.60 |
| EPHA1 | associated_with | gene | 0.60 |
| CLU | associated_with | gene | 0.60 |
| CELF1 | associated_with | gene | 0.60 |
| MEF2C | associated_with | gene | 0.60 |
| PTK2B | associated_with | gene | 0.60 |
| FERMT2 | associated_with | gene | 0.60 |
| ABCA7 | interacts_with | gene | 0.60 |
| BIN1 | interacts_with | gene | 0.60 |
| CASS4 | interacts_with | gene | 0.60 |
| CD2AP | interacts_with | gene | 0.60 |
| CD33 | interacts_with | gene | 0.60 |
| CELF1 | interacts_with | gene | 0.60 |
| CLU | interacts_with | gene | 0.60 |
| CR1 | interacts_with | gene | 0.60 |
| EPHA1 | interacts_with | gene | 0.60 |
| FERMT2 | interacts_with | gene | 0.60 |
| INPP5D | interacts_with | gene | 0.60 |
| MEF2C | interacts_with | gene | 0.60 |
| NME8 | interacts_with | gene | 0.60 |
| PICALM | interacts_with | gene | 0.60 |
| PTK2B | interacts_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| PILRA | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| HLA | associated_with | gene | 0.60 |
| HLA | interacts_with | gene | 0.60 |
| MS4A | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||