gene

PLD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

76Connections

0Hypotheses

0Analyses

50Outgoing

21Incoming

Summary

PLD3 (Phospholipase D3) - lysosomal phospholipase in Alzheimer's disease

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🧬 Gene Info

Gene Symbol	PLD3
Full Name	Phospholipase D3
Chromosome	19q13.32
Protein Type	Enzyme
Function	is an endoplasmic reticulum-resident phospholipase enzyme that plays critical roles in cellular lipid metabolism and lysosomal function.
Primary Expression	brain regions vulnerable to neurodegeneration, and its expression is reduced in Alzheimer's disease brains
Amino Acids	473 aa
Pathways	APP metabolism, Autophagy, Cholesterol, Mitophagy, nucleotide signaling
UniProt ID	Q8N8S7
NCBI Gene ID	23646
Ensembl ID	ENSG00000119608
OMIM	614739
GeneCards	PLD3
Human Protein Atlas	PLD3
Associated Diseases	Alzheimer, Alzheimer's disease, Ms
Interactions	CGAS, STING, APP, TREM2, SREBF2, YY1
KG Connections	76 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PLD3 — AlphaFold Q8N8S7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PLD3["PLD3 (Phospholipase D3)"]
    PINK1["PINK1"]
    MITOPHAGY_GENE["Mitophagy Regulator"]
    APP["APP (Amyloid Precursor Protein)"]
    AMYLOID["Amyloid Beta Production"]
    CGAS["cGAS"]
    STING["STING"]
    INNATE_IMMUNITY["Innate Immune Response"]
    AUTOPHAGY["Autophagy"]
    MITOPHAGY["Mitophagy"]
    MTDNA["Mitochondrial DNA"]
    ALZHEIMER["Alzheimer's Disease"]
    BIN1["BIN1"]
    APOE4["APOE4"]
    CHOLESTEROL["Cholesterol Metabolism"]

    PINK1 -->|"activates"| PLD3
    MITOPHAGY_GENE -->|"regulates"| PLD3
    
    PLD3 -->|"activates"| APP
    PLD3 -->|"promotes"| AMYLOID
    APP -->|"processed to"| AMYLOID
    
    PLD3 -->|"activates"| CGAS
    PLD3 -->|"activates"| STING
    CGAS -->|"triggers"| INNATE_IMMUNITY
    STING -->|"mediates"| INNATE_IMMUNITY
    
    PLD3 -->|"promotes"| AUTOPHAGY
    PLD3 -->|"enhances"| MITOPHAGY
    PLD3 -->|"regulates"| CHOLESTEROL
    
    PLD3 -->|"interacts with"| MTDNA
    PLD3 -->|"associated with"| BIN1
    PLD3 -->|"associated with"| APOE4
    
    AMYLOID -->|"contributes to"| ALZHEIMER
    INNATE_IMMUNITY -->|"contributes to"| ALZHEIMER
    PLD3 -->|"risk factor for"| ALZHEIMER

    style PLD3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style AUTOPHAGY fill:#1b5e20,stroke:#333,stroke-width:2px
    style MITOPHAGY fill:#1b5e20,stroke:#333,stroke-width:2px
    style CHOLESTEROL fill:#1b5e20,stroke:#333,stroke-width:2px
    style AMYLOID fill:#ef5350,stroke:#333,stroke-width:2px
    style INNATE_IMMUNITY fill:#ef5350,stroke:#333,stroke-width:2px
    style ALZHEIMER fill:#7d4200,stroke:#333,stroke-width:2px
    style PINK1 fill:#4a1a6b,stroke:#333,stroke-width:2px
    style CGAS fill:#4a1a6b,stroke:#333,stroke-width:2px
    style STING fill:#4a1a6b,stroke:#333,stroke-width:2px

Outgoing (55)

Target	Relation	Type	Str
mitochondrial DNA	degrades	compound	0.80
nucleotide signaling	regulates	process	0.70
APP metabolism	regulates	process	0.70
Alzheimer	associated_with	disease	0.65
Alzheimer	contributes_to	disease	0.65
Ms	associated_with	disease	0.65
Als	activates	disease	0.65
CGAS	activates	gene	0.60
STING	activates	gene	0.60
APP	activates	gene	0.60
BIN1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
APOE4	associated_with	gene	0.60
APP	contributes_to	gene	0.60
ABCA7	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
CR1	associated_with	gene	0.60
TREM2	activates	gene	0.60
CASS4	associated_with	gene	0.60
CD33	associated_with	gene	0.60
NME8	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CELF1	associated_with	gene	0.60
MEF2C	associated_with	gene	0.60
PTK2B	associated_with	gene	0.60
FERMT2	associated_with	gene	0.60
RIN3	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
PUM1	implicated_in	gene	0.60
STUB1	implicated_in	gene	0.60
YY1	regulates	gene	0.60
SREBF2	interacts_with	gene	0.60
YY1	interacts_with	gene	0.60
AMYLOID	activates	gene	0.60
MITOCHONDRIAL DNA	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
MTDNA	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
DNA	associated_with	gene	0.60
CGAS-STING	activates	gene	0.60
Autophagy	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
Cholesterol	activates	pathway	0.60
AMYLOID	contributes_to	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	contributes_to	gene	0.60

Incoming (21)

Source	Relation	Type	Str
PINK1	activates	gene	0.60
SORL1	associated_with	gene	0.60
APP	activates	gene	0.60
APP	associated_with	gene	0.60
DAB1	implicated_in	gene	0.60
FGF14	implicated_in	gene	0.60
NPTX1	implicated_in	gene	0.60
APP	regulates	gene	0.60
FGF14	regulates	gene	0.60
AKT3	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
EGR1	interacts_with	gene	0.60
FGF14	interacts_with	gene	0.60
MITOPHAGY	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ENDOSOMES	contributes_to	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
DNA	targets	gene	0.60
DNA	associated_with	gene	0.60
APP	co_expressed_with	gene	0.50
PINK1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PLD3

Understanding Entity Pages

Summary

Wiki Pages (21)

PLD3 Gene

Neuroresilience Mechanisms and Evidence

Synaptic Dysfunction in Neurodegeneration

Sporadic Alzheimer's Disease Pathway

MS4A4A Gene — Membrane-Spanning 4-Domains A4A

FTD-ALS Spectrum

Genetics of Progressive Supranuclear Palsy

Microglia

CD33 — Cluster of Differentiation 33

Entities Overview

PLD4 (Phospholipase D Family Member 4)

Alzheimer's Disease Genetic Variants

Advanced Computational Neuroscience and AI-Driven Drug Discovery for CBS/PSP

Neuroimmune Genes in Alzheimer's Disease — TREM2, CD33, PLD3

TREM2+ Border-Associated Macrophages

C4B Gene

Microglia in Frontotemporal Dementia Progression

Neuroimmune Disease Comparison Matrix

AAIC 2026: Epigenetic and Genetic Biomarkers in Alzheimer's