gene

SYN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

104Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

Summary

Page for SYN2 Gene

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🧬 Gene Info

Gene Symbol	SYN2
Full Name	Synapsin II
Chromosome	3p25.2
Protein Family	Synapsin family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	presynaptic terminals of neurons throughout the brain[@masliah2000]
Amino Acids	706 aa
Pathways	MAPK, MAPK pathway
UniProt ID	[Q9UQ88](https://www.uniprot.org/uniprot/Q9UQ88)
Ensembl ID	ENSG00000153147
OMIM	185600
GeneCards	SYN2
Human Protein Atlas	SYN2
Chromosomal location	3p25.2
Gene family	Synapsin family
Associated Diseases	ALS, Autism, Epilepsy, Schizophrenia, autism spectrum disorder
KG Connections	104 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SYN2["SYN2"]
    Pyroptosis["Pyroptosis"]
    Necroptosis["Necroptosis"]
    Dementia["Dementia"]
    Alzheimer["Alzheimer"]
    Autism["Autism"]
    Epilepsy["Epilepsy"]
    Schizophrenia["Schizophrenia"]
    Als["Als"]
    synaptic_vesicle_cycling["synaptic vesicle cycling"]
    axon_outgrowth["axon outgrowth"]
    autism_spectrum_disorders["autism spectrum disorders"]
    APOPTOSIS["APOPTOSIS"]
    ALZHEIMER["ALZHEIMER"]
    RNA["RNA"]
    GAD1["GAD1"]
    SYP["SYP"]
    ASTROCYTES["ASTROCYTES"]
    DEMENTIA["DEMENTIA"]
    SLC32A1["SLC32A1"]
    SYN2 -->|"therapeutic_tar"| Pyroptosis
    SYN2 -->|"therapeutic_tar"| Necroptosis
    SYN2 -->|"therapeutic_tar"| Dementia
    SYN2 -->|"therapeutic_tar"| Alzheimer
    SYN2 -.-|"associated"| Autism
    SYN2 -.-|"associated"| Epilepsy
    SYN2 -.-|"associated"| Schizophrenia
    SYN2 -.-|"associated"| Als
    SYN2 -->|"contributes_to"| Epilepsy
    SYN2 -->|"involved in"| synaptic_vesicle_cycling
    SYN2 -->|"involved in"| axon_outgrowth
    SYN2 -->|"implicated_in"| autism_spectrum_disorders
    SYN2 -->|"therapeutic_tar"| APOPTOSIS
    SYN2 -->|"therapeutic_tar"| ALZHEIMER
    SYN2 -->|"therapeutic_tar"| RNA
    SYN2 -->|"biomarker_for"| GAD1
    SYN2 -->|"biomarker_for"| SYP
    SYN2 -->|"therapeutic_tar"| ASTROCYTES
    SYN2 -->|"therapeutic_tar"| DEMENTIA
    SYN2 -->|"biomarker_for"| SLC32A1
    style SYN2 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (77)

Target	Relation	Type	Str
Pyroptosis	therapeutic_target	disease	0.65
Necroptosis	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Autism	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Epilepsy	contributes_to	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
ALS	associated_with	disease	0.65
synaptic vesicle cycling	involved_in	biological_process	0.60
axon outgrowth	involved_in	biological_process	0.60
autism spectrum disorders	implicated_in	disease	0.60
GAD1	biomarker_for	gene	0.60
SYP	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
GRIN2A	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
SYN1	contributes_to	gene	0.60
SLC17A6	biomarker_for	gene	0.60
SLC12A5	biomarker_for	gene	0.60
Neurotransmitter Release	associated_with	pathway	0.60
Synaptic Vesicle	associated_with	pathway	0.60
SLC17A7	biomarker_for	gene	0.60
Rb	contributes_to	protein	0.60
epilepsy	implicated_in	disease	0.60
epilepsy	associated_with	disease	0.60
APOPTOSIS	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
Endothelial	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
Neuron	expressed_in	cell_type	0.60
EPILEPSY	contributes_to	gene	0.60
RNA	expressed_in	gene	0.60
PYROPTOSIS	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
AND	biomarker_for	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
GENES	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60

Incoming (27)

Source	Relation	Type	Str
SLC17A7	biomarker_for	gene	0.60
SLC17A6	biomarker_for	gene	0.60
SLC12A5	biomarker_for	gene	0.60
SYN1	associated_with	gene	0.60
GRIN2A	biomarker_for	gene	0.60
GAD1	biomarker_for	gene	0.60
SYN1	contributes_to	gene	0.60
SYP	biomarker_for	gene	0.60
SLC32A1	biomarker_for	gene	0.60
SNAP25	biomarker_for	gene	0.60
PVALB	biomarker_for	gene	0.60
SYN1	implicated_in	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
AXON	associated_with	gene	0.60
EPILEPSY	associated_with	gene	0.60
HUB GENES	biomarker_for	gene	0.60
GENES	associated_with	gene	0.60
AND	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
EPILEPSY	contributes_to	gene	0.60
AND	contributes_to	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
SLC17A6	associated_with	gene	0.50
SYN1	co_expressed_with	gene	0.50
slc32a1	associated_with	gene	0.50
AUTISM	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SYN2

Understanding Entity Pages

Summary

Wiki Pages (20)

SYN2 Gene

CHD8 Gene

slc32a1

NRSF Protein

SYNA — Synapsin I

Synapsin II Protein

Synapsin-2 Protein

Nucleus of the Brachium of the Superior Colliculus

Transdiagnostic Proteomic Changes in Neurodegeneration

SYN3 Protein

SYN1 (Synapsin-1)

Medial Terminal Nucleus (MTN)

SYN3 — Synapsin III

SYN2 Protein

Synapsin Neurons

Synapsin-1 Protein (SYN1)

NEUROD1 Protein

SYN1 Gene — Synapsin I