protein

SLC1A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC1A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

40Outgoing

25Incoming

Summary

Page for slc1a1 Protein

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🔬 Protein Info

Gene Symbol	SLC1A1
Protein Type	Transporter
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	pyramidal neurons and medium spiny neurons - Glia: Low expression in astrocytes compared to EAAT1 (GL
Molecular Weight	57 kDa
GeneCards	SLC1A1
Human Protein Atlas	SLC1A1
High-affinity glutamate uptake	Km for glutamate approximately 10-20 μM
Sodium coupling	Transport is driven by the inward Na+ gradient
Stoichiometry	3 Na+ + 1 glutamate + 1 H+ in / 1 K+ out
Electrogenic	Net positive charge influx during transport
Cysteine transport	EAAT3 also transports cystine, supporting glutathione synthesis
Brain	Highest expression in hippocampus (CA1 > CA3 > dentate gyrus), cerebral cortex (layers II-III), basal ganglia (striatum > globus pallidus), and olfactory bulb
Neuronal subtypes	Predominantly expressed in pyramidal neurons and medium spiny neurons
Glia	Low expression in astrocytes compared to EAAT1 (GLAST) and EAAT2 (GLT-1)
Associated Diseases	Alzheimer, Autism, Bipolar, Cancer, Inflammation, Parkinson
Interactions	SLC6A2, HTR2A, CACNA1H, GABRB2, GRIA1, DRD2
KG Connections	65 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC1A1["<b>SLC1A1</b>"]
    Alzheimer["Alzheimer"]
    SLC1A1 -->|"associated with"| Alzheimer
    Cancer["Cancer"]
    SLC1A1 -->|"associated with"| Cancer
    Schizophrenia["Schizophrenia"]
    SLC1A1 -->|"associated with"| Schizophrenia
    Autism["Autism"]
    SLC1A1 -->|"associated with"| Autism
    Parkinson["Parkinson"]
    SLC1A1 -->|"associated with"| Parkinson
    Bipolar["Bipolar"]
    SLC1A1 -->|"associated with"| Bipolar
    Inflammation["Inflammation"]
    SLC1A1 -->|"associated with"| Inflammation
    SLC6A2["SLC6A2"]
    SLC1A1 -->|"associated with"| SLC6A2
    GRIK4["GRIK4"]
    SLC1A1 -->|"associated with"| GRIK4
    GRIA1["GRIA1"]
    SLC1A1 -->|"associated with"| GRIA1
    DRD1["DRD1"]
    SLC1A1 -->|"associated with"| DRD1
    CACNA1B["CACNA1B"]
    SLC1A1 -->|"associated with"| CACNA1B
    GRM5["GRM5"]
    SLC1A1 -->|"associated with"| GRM5
    ALZHEIMER["ALZHEIMER"]
    SLC1A1 -->|"associated with"| ALZHEIMER
    HTR2A["HTR2A"]
    SLC1A1 -->|"associated with"| HTR2A
    GABRA1["GABRA1"]
    SLC1A1 -->|"associated with"| GABRA1
    CACNA1H["CACNA1H"]
    SLC1A1 -->|"associated with"| CACNA1H
    HTR2C["HTR2C"]
    SLC1A1 -->|"associated with"| HTR2C
    DRD2["DRD2"]
    SLC1A1 -->|"associated with"| DRD2
    PARKINSON["PARKINSON"]
    SLC1A1 -->|"associated with"| PARKINSON
    Dopaminergic["Dopaminergic"]
    SLC1A1 -->|"associated with"| Dopaminergic
    INFLAMMATION["INFLAMMATION"]
    SLC1A1 -->|"associated with"| INFLAMMATION
    AND["AND"]
    SLC1A1 -->|"associated with"| AND
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    SLC1A1 -->|"associated with"| PARKINSON_S_DISEASE
    CANCER["CANCER"]
    SLC1A1 -->|"associated with"| CANCER
    GENES["GENES"]
    SLC1A1 -->|"associated with"| GENES
    GABRB2["GABRB2"]
    GABRB2 -->|"associated with"| SLC1A1
    GRIK4["GRIK4"]
    GRIK4 -->|"associated with"| SLC1A1
    CACNA1B["CACNA1B"]
    CACNA1B -->|"associated with"| SLC1A1
    HTR2A["HTR2A"]
    HTR2A -->|"associated with"| SLC1A1

Outgoing (40)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
SLC6A2	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
GABRB2	associated_with	gene	0.60
Rb	associated_with	protein	0.60
SLC6A2	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
Dopaminergic	associated_with	cell_type	0.60
INFLAMMATION	associated_with	gene	0.60
AND	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
GABAergic neurons	expressed_in	cell_type	0.60
Hypothalamus	expressed_in	brain_region	0.55
Cerebellum	expressed_in	brain_region	0.55
Thalamus	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
HTR2A	interacts_with	protein	0.50
CACNA1H	interacts_with	protein	0.50
GABRB2	interacts_with	protein	0.50
GRIA1	interacts_with	gene	0.50
SLC6A2	co_expressed_with	gene	0.50
DOPAMINERGIC	interacts_with	concept	0.50

Incoming (25)

Source	Relation	Type	Str
GABRB2	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
CACNA1H	interacts_with	gene	0.60
GABRB2	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
HTR2A	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DRD2	interacts_with	gene	0.50
HTR2C	interacts_with	gene	0.50
DRD1	interacts_with	gene	0.50
CACNA1B	interacts_with	gene	0.50
GABRA1	interacts_with	gene	0.50
GRM5	interacts_with	gene	0.50
GRIK4	interacts_with	gene	0.50
SLC6A2	interacts_with	gene	0.50
HTR2A	co_expressed_with	protein	0.50
HTR2C	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC1A1

Understanding Entity Pages

Summary

Wiki Pages (9)

slc1a1 Gene

Glutamatergic Signaling Pathway

SLC1A4 Gene

Glutamate Transport

Glutamate Signaling Pathway

slc1a1 Protein

GABRB2 — GABA-A Receptor Beta 2