Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HTR2C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HTR2C is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, therapeutic target. Associated with Alzheimer, Anxiety, Dementia. Connected to 61 entities in the SciDEX knowledge graph.
| Gene Symbol | HTR2C |
| Full Name | 5-Hydroxytryptamine Receptor 2C |
| Chromosome | Xq24 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the central nervous system |
| Molecular Weight | 70 kDa |
| Pathways | MAPK signaling |
| UniProt ID | P28335 |
| NCBI Gene ID | 3358 |
| Ensembl ID | ENSG00000140048 |
| OMIM | 312861 |
| GeneCards | HTR2C |
| Human Protein Atlas | HTR2C |
| Protein Class | G Protein-Coupled Receptor (Class A) |
| Associated Diseases | Alzheimer, Alzheimer'S Disease, Anxiety, Autism, Bipolar |
| Interactions | DRD1, CACNA1B, GABRA1, GRM5, GRIK4, SLC6A2 |
| KG Connections | 139 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HTR2C["<b>HTR2C</b>"]
Alzheimer{"Alzheimer"}
HTR2C -->|"associated with"| Alzheimer
Dementia{"Dementia"}
HTR2C -->|"therapeutic target"| Dementia
Depression{"Depression"}
HTR2C -->|"associated with"| Depression
Anxiety{"Anxiety"}
HTR2C -->|"associated with"| Anxiety
HTR2C -->|"associated with"| Dementia
HTR2C -->|"interacts with"| Dementia
ADRA2A["ADRA2A"]
HTR2C -->|"associated with"| ADRA2A
BCHE["BCHE"]
HTR2C -->|"associated with"| BCHE
SLC6A2["SLC6A2"]
HTR2C -->|"associated with"| SLC6A2
SLC6A3["SLC6A3"]
HTR2C -->|"associated with"| SLC6A3
ABCB1["ABCB1"]
HTR2C -->|"associated with"| ABCB1
SLC6A4["SLC6A4"]
HTR2C -->|"associated with"| SLC6A4
MAOB["MAOB"]
MAOB -->|"associated with"| HTR2C
GABRA1["GABRA1"]
GABRA1 -->|"associated with"| HTR2C
CHAT["CHAT"]
CHAT -->|"associated with"| HTR2C
CYP2D6["CYP2D6"]
CYP2D6 -->|"associated with"| HTR2C
APOE["APOE"]
APOE -->|"associated with"| HTR2C
HMGCR["HMGCR"]
HMGCR -->|"associated with"| HTR2C
OPRM1["OPRM1"]
OPRM1 -->|"associated with"| HTR2C
SLC30A8["SLC30A8"]
SLC30A8 -->|"associated with"| HTR2C
COMT["COMT"]
COMT -->|"associated with"| HTR2C
NBEA["NBEA"]
NBEA -->|"associated with"| HTR2C
BCHE -->|"associated with"| HTR2C
ADRA2A -->|"associated with"| HTR2C
style HTR2C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Anxiety | associated_with | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Dementia | interacts_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Bipolar | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| ADRA2A | associated_with | gene | 0.60 |
| BCHE | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| GSTP1 | associated_with | gene | 0.60 |
| CYP3A4 | associated_with | gene | 0.60 |
| ABCG2 | associated_with | gene | 0.60 |
| ADRB2 | associated_with | gene | 0.60 |
| NBEA | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| CYP2D6 | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| MAOB | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| SLC30A8 | associated_with | entity | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| GRIK4 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| MTHFR | associated_with | gene | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Epigenetic | associated_with | pathway | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| CYP1A2 | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| ANXIETY | associated_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| Epigenetic | interacts_with | pathway | 0.60 |
| PER | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAOB | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| CHAT | associated_with | gene | 0.60 |
| CYP2D6 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| HMGCR | associated_with | gene | 0.60 |
| OPRM1 | associated_with | gene | 0.60 |
| SLC30A8 | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| NBEA | associated_with | gene | 0.60 |
| BCHE | associated_with | gene | 0.60 |
| ADRA2A | associated_with | gene | 0.60 |
| ADRB2 | associated_with | gene | 0.60 |
| GSTP1 | associated_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| ABCG2 | associated_with | gene | 0.60 |
| CYP3A4 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| GRIK4 | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| CACNA1B | interacts_with | gene | 0.60 |
| CACNA1H | interacts_with | gene | 0.60 |
| DRD1 | interacts_with | gene | 0.60 |
| GABRA1 | interacts_with | gene | 0.60 |
| GABRB2 | interacts_with | gene | 0.60 |
| GRIA1 | interacts_with | gene | 0.60 |
| GRIK4 | interacts_with | gene | 0.60 |
| GRM5 | interacts_with | gene | 0.60 |
| HTR2A | interacts_with | gene | 0.60 |
| CYP2C19 | associated_with | gene | 0.60 |
| CYP1A2 | associated_with | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| PER | interacts_with | gene | 0.60 |
| CYP2E1 | associated_with | gene | 0.60 |
| ANXIETY | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| CYP3A5 | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||