gene

HTR2C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR2C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

139Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

HTR2C is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, therapeutic target. Associated with Alzheimer, Anxiety, Dementia. Connected to 61 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolHTR2C
Full Name5-Hydroxytryptamine Receptor 2C
ChromosomeXq24
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe central nervous system
Molecular Weight70 kDa
PathwaysMAPK signaling
UniProt IDP28335
NCBI Gene ID3358
Ensembl IDENSG00000140048
OMIM312861
GeneCardsHTR2C
Human Protein AtlasHTR2C
Protein ClassG Protein-Coupled Receptor (Class A)
Associated DiseasesAlzheimer, Alzheimer'S Disease, Anxiety, Autism, Bipolar
InteractionsDRD1, CACNA1B, GABRA1, GRM5, GRIK4, SLC6A2
KG Connections139 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: HTR2C — AlphaFold P28335 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

HTR2C Gene

gene · 861 words

Lateral Hypothalamus

cell_type · 2514 words

Serotonin 5-HT2A Receptor Neurons

cell · 2093 words

Section 160: Pharmacogenomics and Personalized Medicine in CBS/PSP

therapeutic · 2046 words

Section 216: Advanced Pharmacogenomics and Precision Therapeutics for CBS/PSP

therapeutic · 2034 words

Nucleus Ovoidalis Neurons

cell · 1717 words

Pathway Diagram

graph TD
    HTR2C["<b>HTR2C</b>"]
    Alzheimer{"Alzheimer"}
    HTR2C -->|"associated with"| Alzheimer
    Dementia{"Dementia"}
    HTR2C -->|"therapeutic target"| Dementia
    Depression{"Depression"}
    HTR2C -->|"associated with"| Depression
    Anxiety{"Anxiety"}
    HTR2C -->|"associated with"| Anxiety
    HTR2C -->|"associated with"| Dementia
    HTR2C -->|"interacts with"| Dementia
    ADRA2A["ADRA2A"]
    HTR2C -->|"associated with"| ADRA2A
    BCHE["BCHE"]
    HTR2C -->|"associated with"| BCHE
    SLC6A2["SLC6A2"]
    HTR2C -->|"associated with"| SLC6A2
    SLC6A3["SLC6A3"]
    HTR2C -->|"associated with"| SLC6A3
    ABCB1["ABCB1"]
    HTR2C -->|"associated with"| ABCB1
    SLC6A4["SLC6A4"]
    HTR2C -->|"associated with"| SLC6A4
    MAOB["MAOB"]
    MAOB -->|"associated with"| HTR2C
    GABRA1["GABRA1"]
    GABRA1 -->|"associated with"| HTR2C
    CHAT["CHAT"]
    CHAT -->|"associated with"| HTR2C
    CYP2D6["CYP2D6"]
    CYP2D6 -->|"associated with"| HTR2C
    APOE["APOE"]
    APOE -->|"associated with"| HTR2C
    HMGCR["HMGCR"]
    HMGCR -->|"associated with"| HTR2C
    OPRM1["OPRM1"]
    OPRM1 -->|"associated with"| HTR2C
    SLC30A8["SLC30A8"]
    SLC30A8 -->|"associated with"| HTR2C
    COMT["COMT"]
    COMT -->|"associated with"| HTR2C
    NBEA["NBEA"]
    NBEA -->|"associated with"| HTR2C
    BCHE -->|"associated with"| HTR2C
    ADRA2A -->|"associated with"| HTR2C
    style HTR2C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (83)

TargetRelationTypeStr
Alzheimerassociated_withdisease0.65
Dementiatherapeutic_targetdisease0.65
Depressionassociated_withdisease0.65
Anxietyassociated_withdisease0.65
Dementiaassociated_withdisease0.65

Incoming (56)

SourceRelationTypeStr
MAOBassociated_withgene0.60
GABRA1associated_withgene0.60
CHATassociated_withgene0.60
CYP2D6associated_withgene0.60
APOEassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found