gene

GRIK4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRIK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

92Connections
0Hypotheses
0Analyses
50Outgoing
31Incoming

Summary

Page for GRIK4 - Glutamate Receptor Kainate Type Subunit 4

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🧬 Gene Info
Gene SymbolGRIK4
Full NameGlutamate Ionotropic Kainate Type Subunit 4
AliasesPage for GRIK4, Page for GRIK4 Protein
Chromosome21q21.3
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight~100 kDa
Amino Acids906 aa
Exons16
UniProt IDQ16478
NCBI Gene ID2898
Ensembl IDENSG00000150201
OMIM604153
GeneCardsGRIK4
Human Protein AtlasGRIK4
Associated DiseasesAlzheimer, Autism, Bipolar, Cancer, Depression, Inflammation
InteractionsSLC6A2, SLC1A1, HTR2A, CACNA1H, GABRB2, GRIA1
KG Connections92 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: GRIK4 — AlphaFold Q16479 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

GRIK4 - Glutamate Receptor Kainate Type Subunit 4

gene · 971 words

GRIK3 - Glutamate Receptor Kainate Type Subunit 3

gene · 2977 words

grik2

protein · 1855 words

CA3 Pyramidal Cells

cell · 1433 words

GRIK3 Protein - Glutamate Receptor Kainate Type Subunit 7

protein · 1197 words

GRIK1 - Glutamate Receptor Kainate Type Subunit 1

gene · 1088 words

Pathway Diagram

graph TD
    GRIK4["<b>GRIK4</b>"]
    Ms{"Ms"}
    GRIK4 -->|"therapeutic target"| Ms
    Depression{"Depression"}
    GRIK4 -->|"therapeutic target"| Depression
    GRIK4 -->|"associated with"| Depression
    SLC6A4["SLC6A4"]
    GRIK4 -->|"associated with"| SLC6A4
    KCNK2["KCNK2"]
    GRIK4 -->|"associated with"| KCNK2
    Complement(["Complement"])
    GRIK4 -->|"therapeutic target"| Complement
    Neurogenesis(["Neurogenesis"])
    GRIK4 -->|"therapeutic target"| Neurogenesis
    BDNF["BDNF"]
    GRIK4 -->|"associated with"| BDNF
    GRIK4 -->|"associated with"| Neurogenesis
    GRIK4 -->|"associated with"| Complement
    TRD{"TRD"}
    GRIK4 -->|"associated with"| TRD
    neurodegeneration["neurodegeneration"]
    GRIK4 -->|"implicated in"| neurodegeneration
    BDNF -->|"associated with"| GRIK4
    GENES["GENES"]
    GENES -->|"associated with"| GRIK4
    SLC6A4 -->|"associated with"| GRIK4
    DEPRESSION["DEPRESSION"]
    DEPRESSION -->|"associated with"| GRIK4
    KCNK2 -->|"associated with"| GRIK4
    AND["AND"]
    AND -->|"associated with"| GRIK4
    style GRIK4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (61)

TargetRelationTypeStr
Mstherapeutic_targetdisease0.65
Depressiontherapeutic_targetdisease0.65
Depressionassociated_withdisease0.65
Alzheimerassociated_withdisease0.65
Cancerassociated_withdisease0.65

Incoming (31)

SourceRelationTypeStr
BDNFassociated_withgene0.60
SLC6A4associated_withgene0.60
KCNK2associated_withgene0.60
GABRB2associated_withgene0.60
SLC1A1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found