Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRIK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GRIK4 |
| Full Name | Glutamate Ionotropic Kainate Type Subunit 4 |
| Aliases | Page for GRIK4, Page for GRIK4 Protein |
| Chromosome | 21q21.3 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | ~100 kDa |
| Amino Acids | 906 aa |
| Exons | 16 |
| UniProt ID | Q16478 |
| NCBI Gene ID | 2898 |
| Ensembl ID | ENSG00000150201 |
| OMIM | 604153 |
| GeneCards | GRIK4 |
| Human Protein Atlas | GRIK4 |
| Associated Diseases | Alzheimer, Autism, Bipolar, Cancer, Depression, Inflammation |
| Interactions | SLC6A2, SLC1A1, HTR2A, CACNA1H, GABRB2, GRIA1 |
| KG Connections | 92 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GRIK4["<b>GRIK4</b>"]
Ms{"Ms"}
GRIK4 -->|"therapeutic target"| Ms
Depression{"Depression"}
GRIK4 -->|"therapeutic target"| Depression
GRIK4 -->|"associated with"| Depression
SLC6A4["SLC6A4"]
GRIK4 -->|"associated with"| SLC6A4
KCNK2["KCNK2"]
GRIK4 -->|"associated with"| KCNK2
Complement(["Complement"])
GRIK4 -->|"therapeutic target"| Complement
Neurogenesis(["Neurogenesis"])
GRIK4 -->|"therapeutic target"| Neurogenesis
BDNF["BDNF"]
GRIK4 -->|"associated with"| BDNF
GRIK4 -->|"associated with"| Neurogenesis
GRIK4 -->|"associated with"| Complement
TRD{"TRD"}
GRIK4 -->|"associated with"| TRD
neurodegeneration["neurodegeneration"]
GRIK4 -->|"implicated in"| neurodegeneration
BDNF -->|"associated with"| GRIK4
GENES["GENES"]
GENES -->|"associated with"| GRIK4
SLC6A4 -->|"associated with"| GRIK4
DEPRESSION["DEPRESSION"]
DEPRESSION -->|"associated with"| GRIK4
KCNK2 -->|"associated with"| GRIK4
AND["AND"]
AND -->|"associated with"| GRIK4
style GRIK4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | therapeutic_target | disease | 0.65 |
| Depression | therapeutic_target | disease | 0.65 |
| Depression | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Schizophrenia | associated_with | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Bipolar | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| SLC6A4 | associated_with | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| GRM5 | interacts_with | gene | 0.60 |
| HTR2C | interacts_with | gene | 0.60 |
| Complement | therapeutic_target | pathway | 0.60 |
| Neurogenesis | therapeutic_target | pathway | 0.60 |
| Neurogenesis | associated_with | pathway | 0.60 |
| Complement | associated_with | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| Dopaminergic | associated_with | cell_type | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| Actin | therapeutic_target | protein | 0.60 |
| Bdnf | associated_with | protein | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| GABAergic neurons | expressed_in | cell_type | 0.60 |
| TRD | associated_with | disease | 0.56 |
| Hypothalamus | expressed_in | brain_region | 0.55 |
| Cerebellum | expressed_in | brain_region | 0.55 |
| Thalamus | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF | associated_with | gene | 0.60 |
| SLC6A4 | associated_with | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| GABRB2 | associated_with | gene | 0.60 |
| SLC1A1 | associated_with | gene | 0.60 |
| SLC6A2 | associated_with | gene | 0.60 |
| CACNA1H | associated_with | gene | 0.60 |
| DRD1 | associated_with | gene | 0.60 |
| GRIA1 | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| HTR2C | associated_with | gene | 0.60 |
| HTR2A | associated_with | gene | 0.60 |
| GABRA1 | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| CACNA1H | interacts_with | gene | 0.60 |
| GABRB2 | interacts_with | gene | 0.60 |
| GRIA1 | interacts_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| DEPRESSION | therapeutic_target | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| DRD2 | interacts_with | gene | 0.50 |
| HTR2C | interacts_with | gene | 0.50 |
| DRD1 | interacts_with | gene | 0.50 |
| CACNA1B | interacts_with | gene | 0.50 |
| GABRA1 | interacts_with | gene | 0.50 |
| GRM5 | interacts_with | gene | 0.50 |
| BDNF | co_expressed_with | gene | 0.50 |
| GABRB2 | co_expressed_with | protein | 0.50 |
| GRIA1 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||