gene

SLC6A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC6A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

217Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Norepinephrine transporter gene critical for noradrenergic signaling in brain and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	SLC6A2
Full Name	Norepinephrine Transporter
Chromosome	16q12.2
Protein Type	Transporter
Function	is a gene encoding a critical membrane transport protein responsible for the reuptake of norepinephrine (noradrenaline) from the synaptic cleft back into presynaptic neurons.
Primary Expression	noradrenergic neurons of the central nervous system:
Molecular Weight	70 kDa
Amino Acids	617 aa
Pathways	Epigenetic, autophagy pathway
UniProt ID	[P23975](https://www.uniprot.org/uniprot/P23975)
Ensembl ID	ENSG00000170270
OMIM	163910
GeneCards	SLC6A2
Human Protein Atlas	SLC6A2
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, Anxiety, Autism
Known Drugs/Compounds	antidepressant drugs
Interactions	JUN, SLC1A1, HTR2A, CACNA1H, GABRB2, GRIA1
KG Connections	217 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC6A2["SLC6A2"]
    SLC6A2 -->|"target for"| Dementia["Dementia"]
    SLC6A2 -->|"activates"| Parkinson["Parkinson"]
    SLC6A2 -->|"activates"| Als["Als"]
    SLC6A2 -->|"activates"| ALS["ALS"]
    SLC6A2 -->|"target for"| Epigenetic["Epigenetic"]
    SLC6A2 -->|"activates"| JUN["JUN"]
    GENES["GENES"] -->|"target for"| SLC6A2
    JUN -->|"activates"| SLC6A2
    DNA["DNA"] -->|"activates"| SLC6A2
    PER["PER"] -->|"interacts"| SLC6A2
    GPNMB["GPNMB"] -->|"transports"| SLC6A2
    NUCKS1["NUCKS1"] -->|"transports"| SLC6A2
    CYP2D6["CYP2D6"] -->|"transports"| SLC6A2

Outgoing (117)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
antidepressant drugs	therapeutic_target	drug	0.80
Alzheimer	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Als	activates	disease	0.65
Dementia	associated_with	disease	0.65
Als	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	activates	disease	0.65
Cancer	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Bipolar	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
JUN	activates	gene	0.60
CYP2D6	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GPNMB	associated_with	gene	0.60
APOE	associated_with	gene	0.60
NUCKS1	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
SNCA	transports	gene	0.60
GCH1	transports	gene	0.60
DRD2	transports	gene	0.60
SLC6A3	transports	gene	0.60
LRRK2	transports	gene	0.60
APOE	transports	gene	0.60
ABCB1	transports	gene	0.60
CYP3A4	transports	gene	0.60
SLC6A4	transports	gene	0.60
GABRA1	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60

Incoming (100)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
CHAT	associated_with	gene	0.60
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
CYP3A4	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
ABCG2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SLC6A4	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
GCH1	associated_with	gene	0.60
JUN	activates	gene	0.60
GPNMB	associated_with	gene	0.60
GPNMB	transports	gene	0.60
NUCKS1	transports	gene	0.60
CYP2D6	transports	gene	0.60
NUCKS1	associated_with	entity	0.60
SLC6A3	transports	gene	0.60
APOE	transports	gene	0.60
LRRK2	transports	gene	0.60
SLC6A4	transports	gene	0.60
GCH1	transports	gene	0.60
ABCB1	transports	gene	0.60
DRD2	transports	gene	0.60
SNCA	transports	gene	0.60
CYP3A4	transports	gene	0.60
GABRB2	associated_with	gene	0.60
SLC1A1	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
GRM5	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
ABCB1	translocates_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC6A2

Understanding Entity Pages

Summary

Wiki Pages (21)

SLC6A2 — Norepinephrine Transporter

Locus Coeruleus Noradrenergic Neurons

Noradrenergic System in Neurodegeneration

SLC22A3 — Solute Carrier Family 22 Member 3 (OCT3)

Section 216: Advanced Pharmacogenomics for CBS/PSP

Locus Coeruleus (LC) Noradrenergic Neurons

SLC6A4 Gene — Serotonin Transporter

Norepinephrine (Noradrenaline)

A2 Noradrenergic Neurons

Noradrenergic Neurons (Locus Coeruleus)

Locus Coeruleus Norepinephrine

Catecholaminergic Neurons

NBEA — Neurobeachin

Norepinephrine Signaling Pathway

Nucleus Tractus Solitarius Neurons

Sympathetic Neurons

Reticular Formation Neurons

slc30a8

COMT Gene