Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TIRAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | TIRAP |
| Full Name | TIR Domain-Containing Adaptor Protein |
| Chromosome | 11p15.5 |
| Protein Type | Adaptor Protein |
| Function | is a critical signaling adaptor protein that mediates Toll-like receptor (TLR) signaling in the innate immune system. |
| Primary Expression | microglia, astrocytes, and neurons, where it contributes to neuroinflammator |
| Molecular Weight | 28 kDa |
| Amino Acids | 235 aa |
| Exons | 6 |
| Pathways | Immune Response |
| NCBI Gene ID | 114609 |
| Ensembl ID | ENSG00000150459 |
| GeneCards | TIRAP |
| Human Protein Atlas | TIRAP |
| Cell Type | Expression Level |
| Associated Diseases | ALS, Encephalitis, Inflammation, Multiple Sclerosis, neurodegeneration |
| Interactions | MYD88, TLR4, CD14, TLR, AND, NF-ΚB |
| KG Connections | 52 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
TIRAP["<b>TIRAP</b>"]
MyD88_dependent_pathway(["MyD88-dependent pathway"])
TIRAP -->|"participates in"| MyD88_dependent_pathway
MyD88["MyD88"]
TIRAP -->|"interacts with"| MyD88
Als{"Als"}
TIRAP -->|"interacts with"| Als
Ms{"Ms"}
TIRAP -->|"interacts with"| Ms
Inflammation{"Inflammation"}
TIRAP -->|"associated with"| Inflammation
Nf__b(["Nf-Kappab"])
TIRAP -->|"activates"| Nf__b
Toll_Like_Receptor(["Toll-Like Receptor"])
TIRAP -->|"interacts with"| Toll_Like_Receptor
TLR["TLR"]
TIRAP -->|"activates"| TLR
INFLAMMATION["INFLAMMATION"]
TIRAP -->|"associated with"| INFLAMMATION
MYD88["MYD88"]
TIRAP -->|"activates"| MYD88
Immune_Response(["Immune Response"])
TIRAP -->|"regulates"| Immune_Response
neurodegeneration["neurodegeneration"]
TIRAP -->|"implicated in"| neurodegeneration
TLR -->|"activates"| TIRAP
TLR4["TLR4"]
TLR4 -->|"activates"| TIRAP
CD14["CD14"]
CD14 -->|"activates"| TIRAP
NF__B["NF-KappaB"]
NF__B -->|"activates"| TIRAP
style TIRAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| MyD88-dependent pathway | participates_in | pathway | 0.80 |
| MyD88 | interacts_with | protein | 0.80 |
| Encephalitis | associated_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Multiple Sclerosis | associated_with | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| MYD88 | activates | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| CD14 | activates | gene | 0.60 |
| PAK1 | associated_with | gene | 0.60 |
| MYD88 | associated_with | gene | 0.60 |
| NEK7 | associated_with | gene | 0.60 |
| JNK | associated_with | gene | 0.60 |
| TRAF6 | associated_with | gene | 0.60 |
| LIMK1 | associated_with | gene | 0.60 |
| RAC1 | associated_with | gene | 0.60 |
| ASC | associated_with | gene | 0.60 |
| GSDMD | associated_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| Nf-Κb | activates | pathway | 0.60 |
| Toll-Like Receptor | interacts_with | pathway | 0.60 |
| TLR | activates | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| NF-ΚB | activates | gene | 0.60 |
| CREB | associated_with | gene | 0.60 |
| ERK1/2 | associated_with | gene | 0.60 |
| TCR | associated_with | gene | 0.60 |
| Nf-Κb | associated_with | pathway | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| Toll-Like Receptor | associated_with | pathway | 0.60 |
| Blood-Brain Barrier | associated_with | pathway | 0.60 |
| Epithelial | associated_with | cell_type | 0.60 |
| Monocyte | associated_with | cell_type | 0.60 |
| T Cell | associated_with | cell_type | 0.60 |
| Endothelial | associated_with | cell_type | 0.60 |
| Macrophage | associated_with | cell_type | 0.60 |
| Actin | associated_with | protein | 0.60 |
| Interleukin | associated_with | protein | 0.60 |
| Interferon | associated_with | protein | 0.60 |
| ALS | associated_with | disease | 0.60 |
| TLR4 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||